A5048491954- Microtubule and mitosis dynamics
- Protist diversity and phylogeny
- Cellular transport and secretion
- Lysosomal Storage Disorders Research
- Inflammasome and immune disorders
- Cell Adhesion Molecules Research
- Micro and Nano Robotics
- Cholesterol and Lipid Metabolism
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Photosynthetic Processes and Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
University of California, San Francisco
2022-2023
Ludwig Boltzmann Institute for Cancer Research
2021
Ludwig Boltzmann Institute for Digital Health and Prevention
2021
Medical University of Vienna
2020
Macrophages are immune cells, capable to remodel the extracellular matrix, which can harbor DNA incorporated into neutrophil traps (NETs). To study breakdown of NETs we studied capability macrophage subsets degrade these structures in vitro and vivo a murine thrombosis model. Furthermore, analyzed human abdominal aortic aneurysm samples support our results. Approach Results: were seeded onto blood clots or isolated polarized. All macrophages NETs. For initial breakdown, relied on...
Inflammation is a key process during atherosclerotic lesion development and propagation. Recent evidence showed clearly that especially the inhibition of interleukin (IL)-1β reduced adverse events in human patients. Fatty acid oxidation (FAO) was previously demonstrated to interact with NOD-, LRR- pyrin domain-containing protein 3 (NLRP3) pathway which required for mature IL-1β secretion. To understand possible anti-inflammatory properties FAO inhibition, we tested effect pharmacological...
At each cell division, nanometer-scale components self-organize to build a micron-scale spindle. In mammalian spindles, microtubule bundles called kinetochore-fibers attach chromosomes and focus into spindle poles. Despite evidence suggesting that poles can set length, their role remains poorly understood. fact, many species do not have Here, we probe the pole’s contribution dynamics, function by inhibiting dynein generate spindles whose poles, yet maintain metaphase steady-state length. We...
Abstract At each cell division, nanometer-scale components self-organize to build a micron-scale spindle. In mammalian spindles, microtubule bundles called kinetochore-fibers attach chromosomes and focus into spindle poles. Despite evidence suggesting that poles can set length, their role remains poorly understood. fact, many species do not have Here, we probe the pole’s contribution dynamics, function by inhibiting dynein generate spindles whose poles, yet maintain metaphase steady-state...