A5101468868- Abdominal Trauma and Injuries
- Liver Disease and Transplantation
- Blood groups and transfusion
- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Surgical Simulation and Training
- Organ Transplantation Techniques and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Appendicitis Diagnosis and Management
- Renal Diseases and Glomerulopathies
- Gastrointestinal Tumor Research and Treatment
- Cell Adhesion Molecules Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Minimally Invasive Surgical Techniques
- Innovations in Medical Education
- Anatomy and Medical Technology
- Enhanced Recovery After Surgery
- Hemoglobinopathies and Related Disorders
- Cancer Mechanisms and Therapy
- Simulation-Based Education in Healthcare
Sichuan University
2016-2025
West China Hospital of Sichuan University
2013-2025
Shanghai East Hospital
2016
Shanghai Normal University
2010
Yale University
2009
Problem Toll‐like receptors (TLRs) recognize conserved sequences on the surface of pathogens and trigger effector cell functions. Previously, we described expression TLR3 by human trophoblast their ability to respond (Poly[I:C]). Here evaluate effect Poly[I:C] mouse pregnancy characterize local systemic response. Method study C57B/6 wild type (wt) knockout (TLR3KO) mice were treated with at 16.5 dpc outcome recorded. Morphologic changes, cytokines chemokines levels in blood utero‐placental...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies with <5% five-year survival rate due to late diagnosis, limited treatment options and chemoresistance. There thus an urgent unmet clinical need develop effective anticancer drugs treat pancreatic cancer. Here, we study potential repurposing monensin as drug for chemo-resistant Using two commonly-used cancer cell lines PANC-1 MiaPaCa-2, show that suppresses proliferation migration, cycle progression, while solicits...
Background: Textbook outcome (TO) is a composite measure for surgical quality assessment. The aim of this study was to assess TO following laparoscopic pancreaticoduodenectomy (LPD), identify factors independently associated with achieving TO, and analyze hospital variations regarding the after case-mix adjustment. Methods: This multicenter cohort retrospectively analyzed 1029 consecutive patients undergoing LPD at 16 high-volume pancreatic centers in China from January 2010 August 2016....
Summary Splenectomy is an effective treatment for immune thrombocytopenia (ITP). The effect of COVID‐19 vaccination on splenectomized patients with ITP during the pandemic has not been reported. Therefore, this study aimed to investigate clinical outcomes in these patients. This was a longitudinal ITP. A total 191 were included study. After median follow‐up 114 months, 146 (76.4%) had sustained response splenectomy. During infection, vaccinated showed lower risk severe infections (odds ratio...
Although Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are known to trigger immune thrombocytopenia (ITP), the manifestations of EBV CMV in ITP spleen tissues continue be poorly understood.Our research retrospectively reviewed a total 42 patients 20 healthy control cases from West China Hospital Sichuan University 2008 2012. Patients' characteristics, preoperative platelet counts, expression tissue were analyzed.No statistically significant differences identified for age gender between...
The increased awareness of asplenia-related life-threatening complications has led to the development parenchyma sparing splenic resections in past few years. aim this study is retrospectively analyze feasibility and safety laparoscopic partial splenectomy (LPS) selected emergency patients. From January 2013 December 2015, there were 46 patients, diagnosed with rupture, admitted our department. Selection criteria for LPS: (1) Preoperative CT scan revealed single pole rupture without spleen...
Abstract Fatty acid oxidation and subsequent ketogenesis is one of the major mechanisms to maintain hepatic lipid homeostasis under fasting conditions. Fasting hormone glucagon has been shown stimulate ketone body production through activation PPARα; however, signal pathway linking PPARα largely undiscovered. Here we report that a SIK2-p300-PPARα cascade mediates glucagon’s effect on ketogenesis. p300 interacts with conserved LXXLL motif enhances its transcriptional activity. SIK2 disrupts...
Abstract Intra-abdominal adhesions have consistently posed a challenge for surgeons during procedures. This study aims to investigate the feasibility of utilizing indocyanine green (ICG) in conjunction with near-infrared imaging detection intra-abdominal adhesions. In vitro, we analyzed factors affecting ICG fluorescence. We divided SD rats into groups excretion different digestive tract regions. Additionally, reviewed surgical videos from previous cholecystectomy cases, categorizing them by...
The use of single-incision plus one-port laparoscopic pancreaticoduodenectomy (SILPD + 1) has been never reported, and its safety efficacy remain unknown. This study aimed to evaluate the short-term outcomes SILPD 1 compared with those conventional (CLPD).Fifty-seven cases (LPD) were performed between November 2021, March 2022. Among them, 10 LPD using a device. Based on same inclusion exclusion criteria, 47 traditional 5-trocar included as control group. patient's demographic...
The current laparoscopic splenectomy (LS) procedure used for cirrhotic patients still has limitations. aim of our study was to determine a standard according the splenic size hand-assisted LS (HALS) in with splenomegaly and hypersplenism due cirrhosis.We conducted retrospectively review who underwent between 2008 2011. All were divided into two groups: Group A (19 patients), which patients' operations by HALS, B (20 treated LS. Then classified on basis spleen size: massive (Group A1)...