A5100358218- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- MicroRNA in disease regulation
- Liver physiology and pathology
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
- Connective Tissue Growth Factor Research
- COVID-19 Clinical Research Studies
- Cancer, Lipids, and Metabolism
- ATP Synthase and ATPases Research
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- Carbohydrate Chemistry and Synthesis
- Renal Diseases and Glomerulopathies
- Advanced biosensing and bioanalysis techniques
- Reproductive System and Pregnancy
- Liver Disease and Transplantation
Shanghai Skin Disease Hospital
2020-2025
Tongji University
2020-2025
Wuhan University of Science and Technology
2025
Sichuan University
2015-2024
Westlake University
2024
Anhui Medical University
2020-2024
Second Hospital of Anhui Medical University
2020-2024
Huazhong University of Science and Technology
2019-2024
Chinese Academy of Sciences
2018-2024
Henan University
2024
High salt is positively associated with the risk of many diseases. However, little known about mechanisms. Here we showed that high increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human mouse macrophages. also potentiated lipopolysaccharide-induced macrophage activation suppressed interleukin 4-induced activation. induced aspects by activating p38/cFos and/or Erk1/2/cFos pathways, inhibited Erk1/2/signal transducer activator...
Cell-cell interactions are mediated through compositions expressed on the membrane. Engineering cell surface to display functional modules with high biocompatibility, controllability, and stability would offer great opportunities for studying manipulating these intercellular reactions. However, it remains a technical challenge because of complex dynamic nature Herein, by using three-dimensional (3D) amphiphilic pyramidal DNA as scaffold, we develop biocompatible, effective, versatile...
Exosomes (Exos) are nanoscale natural vehicles for transporting biomolecules to facilitate cell-to-cell communication, indicating a high potential of them delivering therapeutics/diagnostics. To improve their delivery capacity, simple, noninvasive, and efficient strategy functionalizing Exos with effective targeting ligands as well elucidation the cellular uptake mechanism these functionalized was found be necessary, but remained challenge. In this work, we used diacyllipid–aptamer...
Abstract Plasmonic materials can generate strong electromagnetic fields to boost the Raman scattering of surrounding molecules, known as surface-enhanced scattering. However, these are heterogeneous, with only molecules located at ‘hotspots’, which account for ≈ 1% surface area, experiencing efficient enhancement. Herein, we propose patterned plasmonic trimers, consisting a pair dimers bilateral sides and trap particle positioned in between, address this challenge. The trimer configuration...
This study aimed to investigate the association between HLA genotypes and antiepileptic drug-induced cutaneous adverse reactions (AEDs-cADRs) among patients with epilepsy in Ningxia Hui Autonomous Region of Northwest China. Fifteen AEDs-cADRs 30 matched AEDs tolerant controls from anested case-control were tested HLA-A, HLA-B, HLA-DRB1 genotype using polymerase chain reaction sequence-based typing (PCR-SBT). Significant difference was not observed groups terms frequencies. Future studies...
ABSTRACT Although anti‐angiogenic therapies (AATs) have some effects against multiple malignancies, they are limited by subsequent tumor vasculogenesis and progression. To investigate the mechanisms which progression following AATs, we transfected microRNA (miR)‐9 into human umbilical vein endothelial cells (HUVECs) to mimic tumor‐associated in hepatocellular carcinoma simulated AATs vitro vivo. We found that administration of angiogenesis inhibitor vandetanib completely abolished...
Invasive species cause considerable ecological and economic damage. Despite decades of broad impacts invasives on diversity agriculture, the genetic adaptations near-term evolution invading populations are poorly understood. The fall webworm, Hyphantria cunea, a highly successful invasive that originated in North America, spread throughout Northern Hemisphere during past 80 years. Here, we use whole-genome sequencing transcriptome profiling to probe underlying bases for rapid adaptation this...
Trimethyltin chloride (TMT) is an organotin heat stabilizer that widely used in the production of plastics, and has strong toxicity. Here, effect trimethyltin on mouse kidneys its related mechanism were studied by taking TMT with drinking water as a model. Histological examination TUNEL results showed group had typical apoptosis necroptosis characteristics. Therefore, level oxidative stress was detected,and expression genes verified real-time quantitative polymerase chain reaction (qRT-PCR)...
Mesenchymal stem cell (MSC)-based therapies have had positive outcomes both in animal models of cardiovascular diseases and clinical patients. However, the number function MSCs decline during hypoxia serum deprivation (H/SD), reducing their ability to contribute endogenous injury repair. MicroRNA-34a (miR-34a) is originally identified as a TP53-targeted miRNA that modulates functions, including apoptosis, proliferation, senescence via several signaling pathways, hence an appealing target for...
Polymicrobial biofilms, in which mixed microbial species are present, play a significant role persistent infections. Furthermore, polymicrobial biofilms promote antibiotic resistance by allowing interspecies transfer of genes. In the present study, we investigated effectiveness antimicrobial blue light (aBL; 405 nm), an innovative non-antibiotic approach, for inactivation biofilms. Dual-species with Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) as well P....
Cardiac fibrosis is associated with an adverse prognosis in cardiovascular disease, which results a decreased cardiac compliance and ultimately heart failure. Recent studies have identified the role of long non-coding RNA (lncRNA) fibrosis. However, functions many lncRNAs remain to be characterized. Through whole-transcriptome sequencing bioinformatics analysis on mouse model pressure overload-induced fibrosis, we screened key lncRNA termed thrombospondin 1 antisense (THBS1-AS1), was...
Uric acid is typically measured through blood tests, which can be inconvenient and uncomfortable for patients. Herein, we propose a wearable surface-enhanced Raman scattering (SERS) chip, incorporating hydrogel membrane with integrated plasmonic trimers, noninvasive monitoring of uric in sweat. The trimers feature sub 5 nm nanogaps, generating strong electromagnetic fields to boost the signal surrounding molecules. Simultaneously, pumps sweat these gaps, efficiently capturing biomarkers SERS...
Abstract Background Connective tissue growth factor (CTGF) is a potent profibrotic factor, which implicated in fibroblast proliferation, angiogenesis and extracellular matrix (ECM) synthesis. It downstream mediator of some the effects transforming β (TGFβ) potentially induced by hyperglycemia human renal mesangial cells. However, whether high glucose could induce CTGF expression vascular smooth muscle cells (VSMCs) remains unknown. Therefore, this study was designed to test regulate VSMC....
Abstract Background Hypoxia plays an important role in vascular remodeling and directly affects smooth muscle cells (VSMC) functions. Macrophage migration inhibitory factor (MIF) is a well known proinflammatory factor, recent evidence suggests of MIF the progression atherosclerosis restenosis. However, potential link between hypoxia VSMC has not been investigated. The current study was designed to test whether could regulate expression human VSMC. effect modulating on hypoxia-induced...
Physiological opening of the mitochondrial permeability transition pore (mPTP) is indispensable for maintaining function and cell homeostasis, but role mPTP its initial factor, cyclophilin D (CypD), in hepatic steatosis unclear. Here, we demonstrate that excess mediated by an increase CypD expression induced dysfunction. Notably, such perturbation occurred before detectable triglyceride accumulation liver high‐fat diet–fed mice. Moreover, either genetic knockout or pharmacological inhibition...
Focal segmental glomerulosclerosis (FSGS) is a major cause of end-stage renal disease. Recent studies have proposed that plasma soluble urokinase receptor (suPAR) might be causative circulating factor but this proposal has caused controversy. This study aimed to measure urinary suPAR levels in patients with primary FSGS and its significance the pathogenesis FSGS. Sixty-two FSGS, diagnosed between January 2006 2012, complete clinical pathologic data were enrolled, together disease normal...
P2X7 purinergic receptor (P2X7R) has been implicated in several cardiovascular diseases. However, whether it regulates cardiac fibrosis remains elusive. Herein, its involvement the development of was examined using a transverse aortic constriction (TAC) mice model and fibroblasts (CFs) hyperstimulated by TGF- β 1 for 48 hours. Results showed that TAC treatment increased expression P2X7R. Silencing P2X7R with siP2X7R ameliorated effects on activation. Similarly, inhibition Brilliant Blue G...