A5050128587- Telomeres, Telomerase, and Senescence
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- Neonatal Health and Biochemistry
- Intelligent Tutoring Systems and Adaptive Learning
- Phytochemicals and Antioxidant Activities
- Skin Protection and Aging
- Tryptophan and brain disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Tea Polyphenols and Effects
- Monoclonal and Polyclonal Antibodies Research
- Higher Education Learning Practices
- Mitochondrial Function and Pathology
- Educational Assessment and Pedagogy
- Enzyme Structure and Function
- PARP inhibition in cancer therapy
- Mesenchymal stem cell research
- Advanced Breast Cancer Therapies
- Biomedical Research and Pathophysiology
- Genetics, Aging, and Longevity in Model Organisms
Duke University Hospital
2014-2022
Duke Medical Center
2014-2022
Boston Children's Hospital
2020
Duke University
2017-2018
Purdue University West Lafayette
2012
Heritage Christian University
2004
Abstract Intrinsic resistance to anti-HER2 therapy in breast cancer remains an obstacle the clinic, limiting its efficacy. However, biological basis for intrinsic is poorly understood. Here we performed a CRISPR/Cas9-mediated loss-of-function genetic profiling and identified TALDO1 , which encodes rate-limiting transaldolase (TA) enzyme non-oxidative pentose phosphate pathway, as essential cellular survival following pharmacological HER2 blockade. Suppression of TA increases cell...
Cellular senescence is a cell fate characterized by an irreversible cycle arrest, but the molecular mechanism underlying this hallmark remains poorly understood. Through unbiased search for novel regulators in airway basal cells, we discovered that epigenetic regulator ubiquitin-like with PHD and ring finger domain-containing protein 1 (UHRF1) critical regulating progression. Upon injury, cells mouse rapidly induce expression of UHRF1 order to stimulate stem proliferation tissue repair....