A5035073435- Immune Response and Inflammation
- Aquaculture disease management and microbiota
- interferon and immune responses
- Vibrio bacteria research studies
- Microfluidic and Bio-sensing Technologies
- Peptidase Inhibition and Analysis
- Invertebrate Immune Response Mechanisms
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Telomeres, Telomerase, and Senescence
- MicroRNA in disease regulation
- Microfluidic and Capillary Electrophoresis Applications
- Influenza Virus Research Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pacific and Southeast Asian Studies
- Cancer-related molecular mechanisms research
- Genetics, Aging, and Longevity in Model Organisms
- Alzheimer's disease research and treatments
- Ultrasound and Cavitation Phenomena
- Electrowetting and Microfluidic Technologies
- Circular RNAs in diseases
- CAR-T cell therapy research
Duke University
2020-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2020-2023
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2022-2023
Duke University Hospital
2022-2023
Duke Medical Center
2022-2023
Sun Yat-sen University
2016-2019
Acoustic tweezers enable contactless, dynamic, precise, and multifunctional manipulation of bioparticles in Petri dishes.
During initiation and progression, cancerous tissue hijacks a series of elaborate homeostatic mechanisms to avoid immune surveillance, including neuro-immune interactions. Here, we show that amyloid-β precursor protein (APP) its β-cleavage product amyloid-β1-42 (Aβ1-42), well-known in the pathogenesis Alzheimer′s disease (AD), are expressed multiple cancer tissues. However, oncogenic activity APP is due E1 domain, instead Aβ1-42. Mechanistically, restricts cells influx into tumor...
Abstract Parkin (Park2), a RING-between-RING-type E3 ubiquitin ligase, has been implicated in regulating NF-κB. Mutations are associated with Parkinson’s disease. Here we investigated the interaction of Receptor-interacting protein kinase 1 (RIPK1) kinase, key mediator multiple signaling pathways activated by TNFR1 including NF-κB pathway. We report that interacts RIPK1 and mediates K63 ubiquitination on K376 TNFR1-signaling The expression promotes recruitment transforming growth factor β...
The essential branched-chain amino acids (BCAAs) leucine, isoleucine, and valine play critical roles in protein synthesis energy metabolism. Despite their widespread use as nutritional supplements, BCAAs' full effects on mammalian physiology remain uncertain due to the complexities of BCAA metabolic regulation. Here a novel mechanism linking intrinsic alterations metabolism is identified cellular senescence senescence-associated secretory phenotype (SASP), both which contribute organismal...
Interferon gamma (IFNγ) is a Th1 cytokine that critical for innate and adaptive immunity. Toll-like receptors (TLRs) signalling pathways are in early host defence against invading pathogens. miR-146a has been reported to participate the regulation of The known mechanisms integrations between IFNγ TLR incompletely understood, especially teleosts. In this study, orange-spotted grouper (Epinephelus coioides) IFNγ1 IFNγ2, their biological activities, involvements pathway were explored. We...