A5008502414- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- 3D Printing in Biomedical Research
- Nanopore and Nanochannel Transport Studies
- Photoacoustic and Ultrasonic Imaging
- Biosensors and Analytical Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrostatics and Colloid Interactions
- Orbital Angular Momentum in Optics
- Electrohydrodynamics and Fluid Dynamics
- Microbial Inactivation Methods
- Micro and Nano Robotics
- Ultrasound and Cavitation Phenomena
- Antenna Design and Optimization
- Antenna Design and Analysis
- Electrical and Bioimpedance Tomography
- Extracellular vesicles in disease
- Microwave Engineering and Waveguides
- Digital Holography and Microscopy
- Pigment Synthesis and Properties
- Near-Field Optical Microscopy
- Acoustic Wave Phenomena Research
- Optical and Acousto-Optic Technologies
- Geophysical Methods and Applications
University of North Carolina at Charlotte
2024
Duke University
2016-2022
Durham Technical Community College
2016-2021
Acoustic tweezers have recently raised great interest across many fields including biology, chemistry, engineering, and medicine, as they can perform contactless, label-free, biocompatible, precise manipulation of particles cells. Here, we present wave number-spiral acoustic tweezers, which are capable dynamically reshaping surface (SAW) wavefields to various pressure distributions facilitate dynamic programmable particle/cell manipulation. SAWs propagating in multiple directions be...
Abstract The valley degree of freedom in crystals offers great potential for manipulating classical waves, however, few studies have investigated states with complex wavenumbers, graded systems, or dispersion tuning states. Here, we present tunable phononic (PCs) composed hybrid channel-cavity cells three parameters. Our PCs support and Dirac cones wavenumbers. They can be configured to form chirped which edge modes are slowed zero group velocity states, where the energy at different...
Acoustofluidic centrifugation enables the spinning of a fluidic droplet and nanoparticle enrichment separation.
Focusing and enriching submicrometer nanometer scale objects is of great importance for many applications in biology, chemistry, engineering, medicine. Here, we present an acoustofluidic chip that can generate single vortex acoustic streaming inside a glass capillary through using low-power waves (only 5 V required). The generated, conjunction with the radiation force, able to enrich submicrometer- nanometer-sized particles small volume. Numerical simulations were used elucidate mechanism...
The separation of nanoscale particles based on their differences in size is an essential technique to the nanoscience and nanotechnology community. Here, nanoparticles are successfully separated a continuous flow by using tilted‐angle standing surface acoustic waves. field deflects volume, fractionation optimized tuning cutoff parameters. nanoparticlesis demonstrated with ≈90% recovery rate. nanoparticle method versatile, non‐invasive, simple.
Extracellular vesicles and lipoprotein contents are separated based on their acoustic constrast factors.
Acoustic tweezers enable contactless, dynamic, precise, and multifunctional manipulation of bioparticles in Petri dishes.
A disposable acoustofluidic platform was developed for nano/microparticle separation with high versatility, precision, and biocompatibility.
Bacterial separation from human blood samples can help with the identification of pathogenic bacteria for sepsis diagnosis. In this work, we report an acoustofluidic device label-free bacterial samples. particular, exploit acoustic radiation force generated a tilted-angle standing surface wave (taSSAW) field to separate E. coli cells based on their size difference. Flow cytometry analysis separated red (RBCs) shows purity more than 96%. Moreover, electrochemical detection displays reduced...
Acoustofluidics, the fusion of acoustics and microfluidic techniques, has recently seen increased research attention across multiple disciplines due in part to its capabilities contactless, biocompatible, precise manipulation micro-/nano-objects. Herein, a bimodal signal amplification platform which relies on acoustofluidics-induced enrichment nanoparticles is introduced. The dual-function biosensor can perform sensitive immunofluorescent or surface-enhanced Raman spectroscopy (SERS)...
In this article, we demonstrated a handheld smartphone fluorescence microscope (HSFM) that integrates dual-functional polymer lenses with smartphone. The HSFM consists of smartphone, field-portable illumination source, and lens performs both optical imaging filtering. Therefore, compared the existing microscope, does not need any additional filters. Although has traditionally played an indispensable role in biomedical clinical applications due to its high specificity sensitivity for...
An acoustofluidic mixer which can achieve thorough mixing across a wide range of flow rates.
Synthesis of nanoparticles and particulate nanomaterials with tailored properties is a central step toward many applications ranging from energy conversion imaging/display to biosensing nanomedicine. While existing microfluidics-based synthesis methods offer precise control over the process, most them rely on passive, partial mixing reagents, which limits their applicability potentially, adversely alter synthesized products. Here, an acoustofluidic (i.e., fusion acoustic microfluidics)...
Abstract Modern biomedical research and preclinical pharmaceutical development rely heavily on the phenotyping of small vertebrate models for various diseases prior to human testing. In this article, we demonstrate an acoustofluidic rotational tweezing platform that enables contactless, high-speed, 3D multispectral imaging digital reconstruction zebrafish larvae quantitative phenotypic analysis. The acoustic-induced polarized vortex streaming achieves contactless rapid (~1 s/rotation)...
The integration of acoustics and microfluidics (termed acoustofluidics) presents a frontier in the engineering functional micro-/nanomaterials. Acoustofluidic techniques enable active precise spatiotemporal control matter, providing great potential for design advanced nanosystems with tunable material properties. In this work, we introduce an acoustofluidic approach multifunctional three-dimensional nanostructure arrays demonstrate their enrichment biosensing applications. particular, our...
After half a billion years of evolution, arthropods have developed sophisticated compound eyes with extraordinary visual capabilities that inspired the development artificial eyes. However, limited 2D nature most traditional fabrication techniques makes it challenging to directly replicate these natural systems. Here, we present biomimetic apposition eye fabricated using microfluidic-assisted 3D-printing technique. Each microlens is connected bottom planar surface via intracorporal,...
Acoustic black holes offer superior capabilities for slowing down and trapping acoustic waves various applications such as metastructures, energy harvesting, vibration noise control. However, no studies have considered the linear nonlinear effects of on micro/nanoparticles in fluids. This study presents acoustofluidic (AFBHs) that leverage controlled interactions between AFBH-trapped wave particles droplets to enable versatile particle manipulation functionalities, translation,...
Shear stress induced by acoustic vibrating sharp edges lyse cells mechanically.
Decomposition and control of acoustic streaming enable contact-free manipulation bioanalytes digitalized liquid handling.
High-molecular-weight polymeric nanoparticles are critical to increasing the loading efficacy and tuning release profile of targeted molecules for medical diagnosis, imaging, therapeutics. Although a number microfluidic approaches have attained reproducible nanoparticle synthesis, it is still challenging fabricate from high-molecular-weight polymers in size structure-controlled manner. In this work, an acoustofluidic platform developed synthesize size-tunable, (>45 kDa)...
Robotic manipulation of small objects has shown great potential for engineering, biology, and chemistry research. However, existing robotic platforms have difficulty in achieving contactless, high-resolution, 4-degrees-of-freedom (4-DOF) objects, noninvasive maneuvering regions shielded by tissue bone barriers. Here, we present chirality-tunable acoustic vortex tweezers that can tune chirality, transmit through biological barriers, trap single micro- to millimeter-sized control object...
Resolving the temporal dynamics of cell signaling pathways is essential for regulating numerous downstream functions, from gene expression to cellular responses. Mapping these requires exposure cells time-varying chemical signals; are difficult generate and control over a wide range. Herein, we present an acoustofluidic signal generator based on sharp-edge-based micromixing strategy. The device, simply by modulating driving signals acoustic transducer including ON/OFF switching frequency,...