A5101958628- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Cancer-related molecular mechanisms research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pulmonary Hypertension Research and Treatments
- Structural Behavior of Reinforced Concrete
- Electrohydrodynamics and Fluid Dynamics
- Gold and Silver Nanoparticles Synthesis and Applications
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Electrowetting and Microfluidic Technologies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Geotechnical Engineering and Soil Stabilization
- Nanomaterials and Printing Technologies
- Concrete Corrosion and Durability
- Polysaccharides Composition and Applications
- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Landfill Environmental Impact Studies
- Biosensors and Analytical Detection
- Nanopore and Nanochannel Transport Studies
- Geotechnical Engineering and Soil Mechanics
- Additive Manufacturing and 3D Printing Technologies
Children's Hospital of Fudan University
2025
University of Iowa
2017-2024
Xinxiang Medical University
2022-2024
Fudan University
2024
Nanchang University
2024
Pennsylvania State University
2004-2020
Howard Hughes Medical Institute
2017-2020
Central South University
2020
Tongji University
2017
Oregon State University
2015-2016
Rapid and homogeneous mixing inside a microfluidic channel is demonstrated via the acoustic streaming phenomenon induced by oscillation of sidewall sharp-edges. By optimizing design sharp-edges, excellent performance fast speed can be achieved in simple device, making our sharp-edge-based micromixer promising candidate for wide variety applications.
A highly reliable, programmable, and cost-effective acoustofluidic pump is demonstrated utilizing the acoustic streaming effects generated by oscillation of tilted sharp-edge structures.
We present a theoretical analysis and experimental demonstration of particle trapping manipulation around optothermally generated bubbles. show that located within 500 μm surface bubble can be attracted towards by drag force resulting from convective flow. Once the comes in contact with bubble's surface, balance between tension forces pressure traps on allowing to move without detaching. The proposed mechanism is confirmed computational fluid dynamics simulations, calculations, experiments....
During the deep reactive ion etching process, sidewalls of a silicon mold feature rough wavy structures, which can be transferred onto polydimethylsiloxane (PDMS) microchannel through soft lithography technique. In this article, we utilized structures PDMS to initiate and cavitate bubbles in presence acoustic waves. Through bubble cavitation, acoustofluidic approach demonstrates fast, effective mixing microfluidics. We characterized its performance by using viscous fluids such as...
In this work, we develop an in situ method to grow highly controllable, sensitive, three-dimensional (3D) surface-enhanced Raman scattering (SERS) substrates via optothermal effect within microfluidic devices. Implementing approach, fabricate SERS composed of Ag@ZnO structures at prescribed locations inside channels, sites which current fabrication has been arduous. Conveniently, properties the 3D nanostructures such as length, packing density, and coverage can also be adjusted by tuning...
We numerically and experimentally investigate the acoustophoresis of microparticles in standing surface acoustic wave microfluidic devices.
An acoustically actuated, bubble-based technique is developed to investigate the deformability of cells suspended in microfluidic devices. A microsized bubble generated by an optothermal effect near targeted cells, which are a chamber. Subsequently, acoustic actuation employed create localized streaming. In turn, streaming flow results hydrodynamic forces that deform situ. The indicative their mechanical properties. method this study measures biomarkers from multiple single experiment, and...
Reusable acoustic tweezers used for disposable devices are demonstrated using locally transmitted standing surface waves.
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A novel microcapsule system composed of sodium cellulose sulfate (NaCS) and chitosan was prepared by layer-by-layer (LbL) self-assembly technique. As a potential drug delivery system, it had several advantages in biocompatibility biodegradation due to its use natural polysaccharides. Some parameters the preparation microcapsule, such as layers LbL process (up 20 layers), viscosities (50, 100, 200 mPas), outmost layer materials (NaCS or chitosan), NaCl concentrations (0 M, 0.5 1 M), were...
We present a programmable, biocompatible technique for dynamically concentrating and patterning particles cells in microfluidic device. Since our utilizes opto-thermally generated, acoustically activated, surface bubbles, we name it "optoacoustic tweezers". The optoacoustic tweezers are capable of particles/cells at any prescribed locations chamber without the use permanent structures, rendering particularly useful formation flexible, complex cell patterns. Additionally, this has...
The first microfluidic-based on-chip sputum-liquefaction device is demonstrated <italic>via</italic> an acoustofluidic micromixer.
An active, spatiotemporally controllable chemical gradient generator is demonstrated utilizing the acoustic streaming effects induced by acoustically oscillating sharp-edge structures.
Density and mechanical properties (e.g., compressibility or bulk modulus) are important cellular biophysical markers. As such, developing a method to separate cells directly based on these can benefit various applications including biological research, diagnosis, prognosis, therapeutics. potential solution, surface acoustic wave (SAW)-based cell separation has demonstrated advantages in terms of biocompatibility compact device size. However, most SAW-reliant separations achieved using an...
In this work we present an acoustofluidic approach for rapid, single-shot characterization of enzymatic reaction constants Km and kcat. The design involves a bubble anchored in horseshoe structure which can be stimulated by piezoelectric transducer to generate vortices the fluid. enzyme substrate thus mixed rapidly, within 100 ms, yield product. Enzymatic kcat then obtained from rate curves different concentrations while holding concentration constant. We studied β-galactosidase its...
Site-specific electrochemical deposition is used to prepare polystyrene (PS)-Ag Janus particle arrays with superhydrophobic properties. The analyte molecules can be significantly enriched using the property of PS-Ag array before SERS detections, enabling an extremely sensitive detection in a highly diluted solution (