A5101894364- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Phylogenetic Studies
- Mitochondrial Function and Pathology
- Fish Biology and Ecology Studies
- Neonatal and fetal brain pathology
- Spinal Dysraphism and Malformations
- Folate and B Vitamins Research
- Aquaculture disease management and microbiota
- Genetic diversity and population structure
- Heme Oxygenase-1 and Carbon Monoxide
- Neurological Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Anesthesia and Neurotoxicity Research
- Sulfur Compounds in Biology
- MicroRNA in disease regulation
- Immune cells in cancer
- RNA Research and Splicing
- Birth, Development, and Health
- Congenital gastrointestinal and neural anomalies
- Redox biology and oxidative stress
- Nuclear Receptors and Signaling
- Axon Guidance and Neuronal Signaling
- Renin-Angiotensin System Studies
Tongji University
2019-2025
Huashan Hospital
2024-2025
Children's Hospital of Fudan University
2020-2025
Obstetrics and Gynecology Hospital of Fudan University
2025
Yangpu Hospital of Tongji University
2021-2024
Wenzhou Medical University
2024
Center for Clinical Research (United States)
2021-2024
University of Hong Kong
2024
University of California, San Francisco
2024
State Key Laboratory of Medical Neurobiology
2018-2021
ABSTRACT Dopamine receptor DRD1-expressing medium spiny neurons (D1 MSNs) and dopamine DRD2-expressing (D2 are the principal projection in striatum, which is divided into dorsal striatum (caudate nucleus putamen) ventral (nucleus accumbens olfactory tubercle). Progenitors of these arise lateral ganglionic eminence (LGE). Using conditional deletion, we show that mice lacking transcription factor genes Sp8 Sp9 lose virtually all D2 MSNs as a result reduced neurogenesis LGE, whereas D1 largely...
Hyperhomocysteinemia is a common metabolic disorder that imposes major adverse health consequences. Reducing homocysteine levels, however, not always effective against hyperhomocysteinemia-associated pathologies. Herein, we report the potential roles of methionyl-tRNA synthetase (MARS)-generated signals in neural tube defects (NTDs) and congenital heart (CHDs). Increased copy numbers MARS and/or MARS2 were detected NTD CHD patients. MARSs sense transmit its signal by inducing protein lysine...
Abstract The striatum is structurally highly diverse, and its organ functionality critically depends on normal embryonic development. Although several studies have been conducted the gene functional changes that occur during striatal development, a system-wide analysis of underlying molecular lacking. Here, we present comprehensive transcriptome profile allows us to explore trajectory development identify correlation between Huntington’s disease (HD). Furthermore, applied an integrative...
The emergence of myelinating oligodendrocytes represents a pivotal developmental milestone in vertebrates, given their capacity to ensheath axons and facilitate the swift conduction action potentials. It is widely accepted that cortical oligodendrocyte progenitor cells (OPCs) arise from medial ganglionic eminence (MGE), lateral/caudal (LGE/CGE), radial glial (RGCs). Here, we used two different fate mapping strategies challenge established notion LGE generates OPCs. Furthermore,...
Abstract Medium spiny neurons (MSNs) in the striatum, which can be divided into D1 and D2 MSNs, originate from lateral ganglionic eminence (LGE). Previously, we reported that Six3 is a downstream target of Sp8/Sp9 transcriptional regulatory cascade MSN development conditionally knocking out leads to severe loss MSNs. Here, showed mainly functions precursor cells gradually loses its function as MSNs mature. Conditional deletion had little effect on cell proliferation but blocked...
Abstract The leptomeninges play a pivotal role in the central nervous system (CNS), serving both as barrier and conduit for fluid cellular transport. Despite their critical functions, our understanding of leptomeningeal development maturation during human embryogenesis remains limited. This study seeks to bridge this gap. We conducted single-nucleus RNA sequencing on tissues from eight embryos, capturing developmental stages early fetal late mid-fetal phases. Our bioinformatic analyses...
The underlying mechanisms of cerebral ischemia/reperfusion (I/R) injury are unclear. Within this study, we aimed to explore whether p53 inhibition exerts protective effects via the p53/PRAS40/mTOR pathway after stroke and its potential mechanism. Both an in vitro oxygen-glucose deprivation (OGD) model with a primary neuronal culture vivo models (dMCAO or MCAO) were used. We found that infarction size, apoptosis, autophagy less severe KO mice neurons I/R OGD/R injury. By activating mTOR...