A5068438641- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Congenital heart defects research
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Apelin-related biomedical research
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- Glioma Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Olfactory and Sensory Function Studies
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Axon Guidance and Neuronal Signaling
University of California, San Francisco
2016-2023
Broad Center
2016-2018
Broad Institute
2016
Building the human brain As develops, neurons migrate from zones of proliferation to their final locations, where they begin build circuits. Paredes et al. have discovered that shortly after birth, a group proliferates near ventricles migrates in chains alongside circulatory vessels into frontal lobes (see Perspective by McKenzie and Fishell). Young postnatally anterior cingulate cortex then develop features inhibitory interneurons. The number migratory cells decreases over first 7 months...
Abstract Neuroanatomists have long speculated that expanded primate brains contain an increased morphological diversity of inhibitory neurons (INs) 1 , and recent studies identified primate-specific neuronal populations at the molecular level 2 . However, we know little about developmental mechanisms specify evolutionarily novel cell types in brain. Here, reconstruct gene expression trajectories specifying INs generated throughout neurogenic period macaques mice by analysing transcriptomes...
The human amygdala grows during childhood, and its abnormal development is linked to mood disorders. primate contains a large population of immature neurons in the paralaminar nuclei (PL), suggesting protracted possibly neurogenesis. Here we studied PL from embryonic stages adulthood. develops next caudal ganglionic eminence, which generates inhibitory interneurons, yet most express excitatory markers. In children, cells are (DCX+PSA-NCAM+), adolescence many transition into mature...
Highlights•Loss of TGF-β1 regulates excitatory-inhibitory inputs in DA neurons via autocrine mechanism•TGF-β signaling reduces axonal and dendritic growth neurons•Mice lacking TGF-β are persistently hyperactive•Mice exhibit reversal-learning deficitsSummaryNeural circuits involving midbrain dopaminergic (DA) regulate reward goal-directed behaviors. Although local GABAergic input is known to modulate circuits, the mechanism that controls excitatory/inhibitory synaptic balance remains unclear....
Abstract Neurodevelopmental mechanisms have evolved to support the formation of diverse brain structures, such as in humans, during perinatal period. Here, we demonstrate that neonatal gyrencephalic brains harbor an expanded subventricular zone, termed Arc, defined by tiered arrangement doublecortin (DCX)-expressing neuroblasts and vascular enrichment at ventricular wall. The Arc is origin dorsal ventral populations migratory target multiple regions involved higher cognitive functions....