A5101588258- Neuroinflammation and Neurodegeneration Mechanisms
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurological Disease Mechanisms and Treatments
- Sulfur Compounds in Biology
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Environmental Quality and Pollution
- Oxidative Organic Chemistry Reactions
- Hydrogen's biological and therapeutic effects
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Risk Factors
- Protein Tyrosine Phosphatases
- Cerebrovascular and Carotid Artery Diseases
- Immune cells in cancer
- Antimicrobial Peptides and Activities
- Vascular Anomalies and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Bioactive Natural Diterpenoids Research
- Hormonal Regulation and Hypertension
- Biochemical and Structural Characterization
- Heme Oxygenase-1 and Carbon Monoxide
- Lymphoma Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
Xuzhou Medical College
2008-2024
Air Force General Hospital PLA
2024
Zhejiang Sci-Tech University
2016-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Peking Union Medical College Hospital
2022
First Affiliated Hospital Zhejiang University
2020
Zhejiang University
2020
Harbin Institute of Technology
2015-2018
Southwest Jiaotong University
2010
82th Hospital of Pla
2010
Abstract LF11-322 (PFWRIRIRR-NH 2 ) (PFR peptide), a nine amino acid-residue peptide fragment derived from human lactoferricin, possesses potent cytotoxicity against bacteria. We report here the discovery and characterization of its antitumor activity in leukemia cells. PFR inhibited proliferation MEL HL-60 cells by inducing cell death absence classical features apoptosis, including chromatin condensation, Annexin V staining, Caspase activation increase abundance pro-apoptotic proteins....
Colon cancer is one of the most common digestive tract malignancies, having second highest mortality rate among all tumors, with a five-year survival advanced patients only 10%. Efficient, targeted drugs are still lacking in treating colon cancer, so it urgent to explore novel druggable targets. Here, we demonstrated that annexin A1 (ANXA1) was overexpressed tumors 50% patients, and ANXA1 overexpression significantly negatively correlated poor prognosis cancer. promoted abnormal...
Abstract Doxorubicin (Dox) is a highly effective anti‐neoplastic agent. Still, its utility in the clinic has been hindered by toxicities, including vomiting, hematopoietic suppression and nausea, with cardiotoxicity being most serious side effect. Genistein (Gen) natural product extensive biological effects, anti‐oxidation, anti‐tumor, cardiovascular protection. This study evaluated whether Gen protected heart from Dox‐induced explored underlying mechanisms. Male Sprague–Dawley (SD) rats...
The present study aimed to investigate the prognostic value of baseline <sup>18</sup>F‑FDG PET/CT quantitative parameters and interim treatment response, assess whether combination these could improve predictive efficacy in patients with diffuse large B‑cell lymphoma (DLBCL) receiving R‑CHOP chemotherapy. images clinical data 64 DLBCL who had undergone scan before after 3 or 4 cycles chemotherapy were retrospectively reviewed. including standardized uptake (SUV), metabolic tumor volume...
Abstract Background Pulmonary arterial hypertension (PAH) is a rare complication of primary Sjögren’s syndrome (pSS). Several genes have proven to be associated with pSS and PAH. However, there no study specifically addressing the genetic susceptibility in combined Methods Thirty-four unrelated patients pSS-PAH were recruited from April 2019 July 2021 at Peking Union Medical College Hospital. Demographic clinical data recorded detail, peripheral blood samples collected for whole-exome...
With the contradiction between energy supply and demand around world, urbanization formed with high-investment, high-consumption, high-emission has significantly impaired ecological environment of China. The evaluation environmental impact is a must for decision-makings related to sustainable urbanization. This paper assessed dynamic performance 285 cities in China from 2005 2013 based on Malmquist-Luenberger index, an expanded data envelopment analysis (DEA) model. To ensure comparability...
The EmPHasis-10 questionnaire is a disease-specific quality of life (QoL) measurement in patients with pulmonary hypertension. We report the results cross-cultural validation Chinese version and its relationship risk stratification connective tissue disease-associated arterial hypertension (CTD-PAH).
Objective: To explore the interaction of smoking and diabetes on stroke. Methods: In this case-control study, a face to questionnaire survey was conducted. Logistic regression models were used analyze relationship between or The indicators calculated according Bootstrap method in study. Results: A total 918 cases healthy controls, who participated chronic disease risk factor Xuzhou 2013, included analysis found that cigarette associated with stroke (OR=1.63, 95%CI: 1.33-2.00), also (OR=2.75,...
Alzheimer's disease (AD) is an age-related neurodegenerative associated with cognitive decline and memory loss. It has been shown that alcohol drinking affects the mechanisms of neurodegeneration in patients AD. This paper reviews effects on major factors involved AD pathogenesis, including formation aggregation beta-amyloid, posttranslational modulation microtubule-associated proteins, induction oxidative stress degeneration acetylcholine system.
Innovation is the strategic support to social productive forces increased and source of enterprise progress, more scholars pay close attention innovation ability. Quantitative evaluation has contributed understanding innovative behavior providing guidance for enterprises develop strategies. In order analyze current situation construction industry innovation, improve ability promote sustainable healthy development enterprises, this paper reviews building summarizes status enterprises. It adds...
Objective To explore the feasibility and safety of urokinase intravasal thrombolysis double interventional therapy in patients with acute infarction. Methods 9 cerebral infarction within 6h were study group, 900 000 units dissolved into 100 ml saline was used as intravenous drip for these patients, meanwhile, 3D DSA examination conducted to confirm artery position thrombus, then mechanical by micro-guiding-wire small dose done. 1 200 120 control group (16cases). Results 6 cases generally...
Abstract Background Cisplatin is a commonly used adjuvant chemotherapy for advanced bladder cancer, but its immune related mechanism still unclear. Exploration the effects of cisplatin in cancer would complement comprehensive and provide basis combination therapy immunotherapy cancer. Methods We confirmed on T24 TCCSUP cell lines vitro exploration important function these microenvironment mice tumor model. Results found induced response by RNA sequencing, validated cGAS-STING signal was...