A5108372356- Medicinal Plants and Bioactive Compounds
- Alzheimer's disease research and treatments
- Saffron Plant Research Studies
- Arsenic contamination and mitigation
- Genomics, phytochemicals, and oxidative stress
- S100 Proteins and Annexins
- Cholinesterase and Neurodegenerative Diseases
- Immune Response and Inflammation
- Antioxidant Activity and Oxidative Stress
- Traditional Chinese Medicine Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Neurological Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Neurological Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Biosimilars and Bioanalytical Methods
- Energy and Environment Impacts
- Nanoplatforms for cancer theranostics
- Breast Cancer Treatment Studies
- Retinoids in leukemia and cellular processes
- Schizophrenia research and treatment
- Air Quality and Health Impacts
- Traditional Chinese Medicine Analysis
- Coal and Its By-products
- Advanced Breast Cancer Therapies
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2006-2025
First Hospital of China Medical University
2018-2024
Shanxi University
2017-2024
Fourth Hospital of Hebei Medical University
2020-2024
Hebei Medical University
2020-2024
China Medical University
2016-2024
Hangzhou Medical College
2024
Inner Mongolia University
2021-2023
China Nerin Engineering (China)
2023
Xuzhou Medical College
2018-2022
Arsenic trioxide (ATO) is an excellent therapy for acute promyelocytic leukemia; however, its use limited due to cardiotoxicity. Crocin (CRO) possesses abundant pharmacological and biological properties, including antioxidant, anti-inflammatory, anti-apoptotic. This study examined the cardioprotective effects of crocin explored their mechanistic involvement in ATO-induced Forty-eight male rats were treated with ATO induce In combination ATO, CRO given evaluate cardioprotection. The results...
Near-infrared window II (NIR-II, 1000-1700 nm) imaging displays the advantages in deep-tissue high-contrast vivo on strength of high temporal-spatial resolution and deeper penetration. However, clinical utility NIR-II agents is limited by their single function. Herein, for first time, we report design a multifunctional drug delivery system (DDS) assembly, CQ/Nd-MOF@HA nanohybrids, with fluorescence (1067 nm), large Stokes shifts, ultrahigh quantum yield, which combined targeted luminescence...
The primary objective of this study was to investigate the role miR-146a in inducing inflammatory infiltration macrophages polymyositis/dermatomyositis (PM/DM) through targeting TNF receptor associated factor 6 (TRAF6), which may further down-regulate Interleukin-17 (IL-17)/Intercellular Adhesion Molecule 1 (ICAM-1) pathway.Biopsies were collected from PM/DM patients and healthy volunteers. model establishment macrophage isolation performed on Sprague Dawley (SD) rats. Model rats treated...
Retinopathy of prematurity (ROP), which is characterized by retinal neovascularization (RNV), a major cause neonatal blindness. The primary treatment for ROP anti-vascular endothelial growth factor (VEGF) therapy, costly and can rapidly lead to desensitization. Celastrol, bioactive compound extracted from Tripterygium wilfordii Hook F. ("Thunder God Vine"), has been shown exert anticancer anti-inflammatory effects. However, whether celastrol antiangiogenic activity suppress inflammation...
Hesperidin (HES) is an abundant and economical dietary bioflavonoid, it has several pharmacological properties such as antioxidant activity powerful cardiac protection. However, HES protection against cisplatin (CP)-induced cardiotoxicity its mechanism have not been fully clarified. The current study was performed to further elucidate the of CP-induced cardiotoxicity. Mice were orally administered (100 or 300 mg kg-1 day-1) for 7 consecutive days then injected intraperitoneally (i.p.) with...
Aims: Our objective is to assess the therapeutic impact of HEC on OAB rats and investigate potential mechanisms. Background: Overactive bladder (OAB) a syndrome urinary storage symptoms characterized by “urinary urgency with or without acute incontinence, usually accompanied increased daytime nocturnal urination”, which impacts patients’ quality life. We found HuangE capsules (HEC) patients through clinical practice. However, exact effect mechanism action remain unclear. Methods: developed...
Arsenic trioxide (ATO) is commonly used to treat patients with acute promyelocytic leukemia since it was authorized by the U.S. Food and Drug Administration in 1970s, but its applicability has been limited cardiotoxic effects. Therefore, aim of present study investigate cardioprotective effects underlying mechanism crocetin (CRT), critical ingredient saffron. Sprague‑Dawley rats were then randomly divided into four groups (n=10/group): i) Control group; ii) ATO group, iii) CRT‑low (20 mg/kg)...
Ambient fine particulate matter (PM2.5) is a complex mixture associated with lung cancer risk. PM2.5-bound nitro-polycyclic aromatic hydrocarbons (NPAHs) have been demonstrated to possess mutagenicity and carcinogenicity. Previous studies showed that PM2.5 induced DNA damage, whereas there little knowledge of whether 9-nitroanthracene (9-NA), typical compound NPAHs in PM2.5, causes damage. Also, the regulating mechanisms 9-NA damage repair are not yet fully established. Here we sought...
Arsenic trioxide (ATO)‑induced hepatotoxicity limits the therapeutic effect of acute myelogenous leukemia treatment. Magnesium isoglycyrrhizinate (MgIG) is a natural compound extracted from licorice and hepatoprotective drug used in liver injury. It exhibits anti‑oxidant, anti‑inflammatory anti‑apoptotic properties. The aim present study was to identify protective action underlying mechanism MgIG against ATO‑induced hepatotoxicity. A total 50 mice were randomly divided into five groups...
A multifunctional DDS, CaO 2 /DOX@Cu/ZIF-8@HA (CDZH), for tumor-targeted H O self-supply, bioimaging, and chemo/chemo-dynamic synergetic therapy was designed.
In the semiarid grassland ecosystems of eastern Inner Mongolia, interrelations among species diversity different plant communities, productivity, soil nutrients and climate were thoroughly studied through integrated approaches combined with sample method, correlation analysis structural equation modelling (SEM) model. The results show that colonization perennial grasses was promoted in wetter colder conditions. productivity determined by grasses, while dominated forbs. We obtained a U-shaped...
Liver injury from any number of causes (e.g. chemical material, drugs and diet, viral infection) is a global health problem, its mechanism not clearly understood. MicroRNAs (miRNAs) expression profiling gaining popularity because miRNAs, as key regulators in gene networks, can influence many biological processes have also shown promise biomarkers for disease. Previous studies reported the regulation effects miRNAs liver injury, whereas function molecular mechanisms miR-322-5p were still...