A5100379995- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Plant Pathogens and Fungal Diseases
- Nail Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Musculoskeletal pain and rehabilitation
- Ion channel regulation and function
- Redox biology and oxidative stress
- Pain Mechanisms and Treatments
- Cardiac electrophysiology and arrhythmias
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioactive Compounds in Plants
- Cutaneous lymphoproliferative disorders research
- Yeasts and Rust Fungi Studies
- Autophagy in Disease and Therapy
- Retinal and Macular Surgery
- Phytochemistry and biological activity of medicinal plants
- Uterine Myomas and Treatments
- Genomics, phytochemicals, and oxidative stress
- Yersinia bacterium, plague, ectoparasites research
Binzhou University
2025
Binzhou Medical University
2025
Hebei University
2024
University of Southern California
2024
Tang Du Hospital
2024
Air Force Medical University
2023-2024
Linyi University
2023
China University of Mining and Technology
2023
Tianjin Medical University General Hospital
2023
Hangzhou Medical College
2023
Hesperetin (HSP) is a natural flavonoid that offers useful curative effects for cardiovascular diseases, but its effect on myocardial ischemia and precise mechanism remains unclear. The aim of this study to explore the potential cardioprotective HSP caused by isoproterenol (ISO). Adult male Kunming mice were randomly divided into five groups: control, ISO, low-dose (L-HSP, 25 mg/kg/d), high-dose (H-HSP, 50 verapamil (VER) group. Treatment groups received or VER seven days, other than control...
Scope [6]‐Gingerol is one of the primary pungent constituents ginger. While [6]‐gingerol has many pharmacological effects, its benefits for myocardial fibrosis, including exact role and underlying mechanisms, remain largely unexplored. The present study designed to characterize cardio‐protective effects in fibrosis mice possible mechanisms. Methods results Mice are subcutaneously injected with isoproterenol (ISO, 10 mg kg −1 ) gavaged (10, 20 day 14 days. Pathological alterations, oxidative...
8-gingerol (8-Gin) is the series of phenolic substance that extracted from ginger. Although many studies have revealed 8-Gin has multiple pharmacological properties, possible underlying mechanisms against myocardial fibrosis (MF) remains unclear. The study examined exact role and potential isoproterenol (ISO)-induced MF. Male mice were intraperitoneally injected with (10 20 mg/kg/d) concurrently subcutaneously ISO for 2 weeks. Electrocardiography, pathological heart morphology, enzymes,...
Endometrial cancer (EC) associated with endogenous hormone metabolism, obesity, diabetes, and inappropriate dietary habits has shown a rising trend in recent years. Various therapeutics methods including approaches (vital phytochemicals) offer healthy nontoxic strategies against cancer. To date, 6-shogaol as one of the antitumor phytochemicals remains unexplored human endometrial cells. In our study, obtained from Zingiber officinale rhizomes separated purified by HPLC, LC-MS/MS, NMR...
10-Gingerol (10-Gin), an active ingredient extracted from ginger, has been reported to have beneficial effects on the cardiovascular system. However, its protective myocardial ischemia (MI) and underlying cellular mechanisms are still unclear. To investigate protection conferred by 10-Gin against MI injury potential in cardiomyocytes via patch-clamp molecular biology techniques. A rat model was established using subcutaneous injection of isoproterenol (85 mg/kg) administered two consecutive...
Arsenic trioxide (ATO)‑induced hepatotoxicity limits the therapeutic effect of acute myelogenous leukemia treatment. Magnesium isoglycyrrhizinate (MgIG) is a natural compound extracted from licorice and hepatoprotective drug used in liver injury. It exhibits anti‑oxidant, anti‑inflammatory anti‑apoptotic properties. The aim present study was to identify protective action underlying mechanism MgIG against ATO‑induced hepatotoxicity. A total 50 mice were randomly divided into five groups...
Monoammonium glycyrrhizinate (MAG) is an aglycone of glycyrrhizin that found in licorice and often used clinically as injection to treat liver diseases. However, the effect MAG on cardiac function its possible cellular mechanisms remain unclear. We explored protective effects against myocardial ischemic injury (MII) induced by isoproterenol (ISO), well via molecular biology techniques patch-clamp recording.A rat model ischemia was administering ISO (85 mg/kg) subcutaneously for 2 consecutive...
Objectives Alantolactone (AL) is a compound extracted from the roots of Inula Racemosa that has shown beneficial effects in cardiovascular disease. However, cardioprotective mechanism AL against hypoxic/ischemic (H/I) injury still unclear. This research aimed to determine AL’s ability protect heart isoproterenol (ISO)-induced MI vivo and cobalt chloride (CoCl 2 ) induced H/I vitro. Methods Electrocardiography (ECG), lactate dehydrogenase (LDH), creatine kinase (CK), cardiac troponin I (cTnI)...
Parkinson's disease (PD) is one of the neurodegenerative diseases that characterized by obvious motor and some nonmotor symptoms. Various therapeutics failed in effective treatment PD because impaired neurological function brain various complications. Periplaneta Americana oligosaccharides (OPA), main active ingredients extracted from medicine residues (P. Americana), have been reported to exert anti-inflammatory effects. The purpose this study was evaluate possible mechanisms OPA against...
This investigation examined the effects of microRNA miR-34c-5p on proliferation, migration, and invasion oral squamous cell carcinoma (OSCC) mechanisms involved.The Gene Expression Omnibus (GEO) database was used to filter chips, GEO2R software (https://www.ncbi.nlm.nih.gov/geo/geo2r/) analyze microarray data (GSE28100 GSE45238). set enrichment analysis (GSEA) study relationship between expression distant metastasis pathological grade OSCC. The correlation TRIM29 (tripartite motif containing...
ABSTRACT Malassezia globosa is a lipophilic basidiomycetous yeast that occurs abundantly in breast tumors and may contribute to shortened overall survival of cancer (BRAC) patients, suggesting the participate carcinogenesis BRAC. However, mechanisms involved M. -based acceleration BRAC are unknown. Here, we show can colonize mammary tissue 7,12-dimethylbenz[a] anthracene-induced mice. The abundance increased tumor incidence. Transcriptome data illustrated IL-17A plays key role growth due...
ABSTRACT Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a promising technique for the rapid identification microorganisms. The aim of this study was to create new database accurate Candidozyma auris (formerly known as Candida ) and 11 species haemuli complex, including C. chanthaburiensis , duobushaemuli heveicola khanbhai konsanensis metrosideri ohialehuae pseudohaemuli ruelliae vulturna . Seventy-one isolates from different national...
A simple glycal diazidation protocol has been developed using light-accelerated and metal-/photocatalyst-free conditions. This method provided entries to a series of new diazido sugar acids that exhibited promising antiviral activity.
Ischemia/hypoxia (I/H)-induced myocardial injury has a large burden worldwide. Hesperetin (HSP) cardioprotective effect, but the molecular mechanism underlying this is not clearly established. Here, we focused on protective mechanisms of HSP against I/H-induced myocardium injury. H9c2 cardiomyocytes were challenged with CoCl2 for 22 h to imitate hypoxia after treatment groups received 4 h. The viability was evaluated, and cardiac function indices, reactive oxygen species, apoptosis,...
YangXinDingJi (YXDJ) capsule is one of traditional Chinese medicines (TCMs) derived from Zhigancao decoction, which usually used for the treatment cardiovascular disease in China. Aim Study. Cardiovascular events are leading causes death worldwide. Myocardial ischemia (MI) severely reduces myocyte longevity and function. The has been clinical cardiac Nevertheless, underlying cellular mechanisms benefits to heart function resulting use this still unclear. aim study was evaluate protective...