A5055631674- Radiopharmaceutical Chemistry and Applications
- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Peptidase Inhibition and Analysis
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Protease and Inhibitor Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Soil Carbon and Nitrogen Dynamics
- Cancer-related Molecular Pathways
- Diet, Metabolism, and Disease
- Angiogenesis and VEGF in Cancer
- Estrogen and related hormone effects
- Advanced Neuroimaging Techniques and Applications
- Bone Metabolism and Diseases
- Neuropeptides and Animal Physiology
- Traditional Chinese Medicine Analysis
- Lanthanide and Transition Metal Complexes
Binzhou University
2024-2025
Binzhou Medical University
2024-2025
Shenyang Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
National Development and Reform Commission
2024
Osaka University
2018-2021
ORCID
2021
Xiangya Hospital Central South University
2017
Central South University
2017
Fibroblast activation protein (FAP), which promotes tumor growth and progression, is overexpressed in cancer-associated fibroblasts of many human epithelial cancers. Because its low expression normal organs, FAP an excellent target for theranostics. In this study, we used radionuclides with relatively long half-lives, 64Cu (half-life, 12.7 h) 225Ac 10 d), to label inhibitors (FAPIs) mice pancreatic cancer xenografts. Methods: Male nude (body weight, 22.5 ± 1.2 g) were subcutaneously injected...
Fibroblast activation protein (FAP), which has high expression in cancer-associated fibroblasts of epithelial cancers, can be used as a theranostic target. Our previous study 64Cu and 225Ac-labelled FAP inhibitors (FAPI-04) for FAP-expressing pancreatic cancer xenograft imaging therapy. However, the optimal therapeutic radionuclide FAPI needs to investigated further. In this study, we evaluated effects beta-emitter (177Lu)-labelled FAPI-46 alpha-emitter (225Ac)-labelled models.PET scans (1 h...
<sup>211</sup>At is an α-emitter that has similar chemical properties to iodine and used in targeted α-therapy. In the present study, we added ascorbic acid (AA) solution increase radiochemical purity of astatide evaluated its efficacy against differentiated thyroid cancer, which characterized by expression sodium/iodide symporter (NIS). <b>Methods:</b> Crude (AA(−)) treated with AA (AA(+)) were prepared. Uptake was compared between 2 solutions normal male Wistar rats (<i>n</i> = 6)....
Phenylalanine derivatives, which target tumors especially through L-type amino acid transporter-1 (LAT1), have elicited considerable attention. In this study, we evaluated the treatment effect of phenylalanine labeled with alpha emitter astatine (211At-PA) in tumor bearing mice. The C6 glioma, U-87MG, and GL261 cell lines were subjected to a cellular 211At-PA uptake analysis that included an evaluation inhibition by system L transporter inhibitor 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic...
Capsaicinoids exist in chili peppers, whereas capsinoids are present some sweet peppers. The study investigated the effects of capsaicinoids and on plasma lipids, relaxation aorta, atherosclerotic plaque development, fecal sterol excretion hamsters fed a high-cholesterol diet. Five groups male were given control diet or one four experimental diets containing 1.3 mmol (NL), 2.6 (NH), (OL), (OH), respectively. Results showed but not could decrease total cholesterol (TC), reduce formation...
Introdution: Immune checkpoint inhibitors (ICIs) have significantly improved clinical outcomes for a wide range of cancers but can also lead to serious or fatal immune-related adverse events (irAEs). Although ICI-related pericardial toxicities been reported, the features are not well characterized in real-world studies. Objective: To characterize main and identify factors associated with death. Methods: Data from January 1, 2011 March 31, 2020 FDA Adverse Event Reporting System database were...
Astatine (211At) is a promising alpha emitter as an alternative to iodine (131I). We are preparing the first-in-human (FIH) clinical trial of targeted therapy for differentiated thyroid cancer in consultation with Pharmaceuticals and Medical Devices Agency. Here, we performed extended single-dose toxicity examination under reliability standard, preclinical safety assessment [211At]NaAt determine FIH dose. solution was injected into normal 6-week-old mice (male (n = 50) female 50), body...
We recently reported the dose-dependent therapeutic effect of 211At-NaAt in differentiated thyroid cancer xenograft models. In present study, we evaluated radiation-induced toxicity using detailed hematological, biochemical, and histological analyses. Biodistribution was measured normal ICR mice (n = 12), absorbed doses major organs were calculated. Groups 60) injected with 0.1 MBq or 1 211At-NaAt, saline as control group 30). Body weight food intake followed up for 60 days. Blood cell...
Background Abnormal levels of glutamate constitute a key pathophysiologic mechanism in epilepsy. The use chemical exchange saturation transfer (GluCEST) imaging to measure pediatric epilepsy is rarely reported research. Purpose To investigate hippocampal level variations and the correlation between subregional volumes. Study Type Cross‐sectional, prospective. Subjects A total 38 school‐aged patients with structurally normal MRI as determined by at least two independent radiologists (60%...
PET radioligands with low molar activity (MA) may underestimate the quantity of target interest because competitive binding unlabeled ligand. The aim this study was to evaluate change in whole-body distribution <sup>18</sup>F-PSMA-1007 targeting prostate-specific membrane antigen (PSMA) when solutions different peptide concentrations are used. <b>Methods:</b> Mouse xenograft models LNCaP (PSMA-positive prostate cancer) (<i>n</i> = 18) were prepared and divided into 3 groups according...
This study investigates the impact of methadone maintenance treatment (MMT) on brain glymphatic system (GS) in opioid addiction China. A total 51 male MMT patients, 48 demographically matched healthy controls (HCs), and 20 heroin dependents (HDs) were recruited for this study. The GS functioning was assessed using diffusion-tensor-imaging analysis along perivascular spaces (DTI-ALPS index) bilateral ALPS divergency (DivALPS). Group differences analyzed utilizing ANOVA two-sample
Abstract Purpose Fibroblast activation protein (FAP), which has high expression in cancer-associated fibroblasts of epithelial cancers, can be used as a theranostic target. Our previous study 64 Cu and 225 Ac-labelled FAP inhibitors (FAPI-04) for FAP-expressing pancreatic cancer xenograft imaging therapy. However, the optimal therapeutic radionuclide FAPI still needs to further investigated. In this study, we evaluated effects beta-emitter( 177 Lu)-labelled FAPI-46 alpha-emitter(...
The receptor activator of nuclear factor κB (RANK) axis is the fundamental signaling pathway in bone formation as well tumor pathophysiology. aim present study was to evaluate impact expression RANK and its downstream molecule Akt1 on progression patients with osteosarcoma. Expression examined 78 human osteosarcoma samples by immunohistochemistry using formalin-fixed samples. Following this, each graded result correlated clinicopathological parameters patient survival. In total, 60...
Fluorocitrate (FC) is a specific metabolic inhibitor of the tricarboxylic acid (TCA) cycle in astrocytes. The purpose this study was to evaluate whether inhibition astrocyte TCA by FC would affect oxygen metabolism rat brain. At 4 h after intracranial injection, rats (n = 9) were investigated 15O-labeled gas PET measure cerebral blood flow (CBF), rate (CMRO2), extraction fraction (OEF), and volume (CBV). After 15O-gas PET, given an intravenous injection 14C-acetate for autoradiography....
Tumor blood flow (TBF) is related to drug delivery and hypoxia, both of which can impact the efficacy anti-cancer therapies. Although integrin αvβ3 expression tumor angiogenesis, it remains unclear whether degree angiogenesis affects TBF. This study aimed evaluate in mouse models using [68Ga]Ga-DOTA-c(RGDfK) peptide positron emission tomography (PET) immunohistochemical staining. PET studies were conducted C6 glioma MIA PaCa-2 (n = 6 each). The was injected via tail vein (2.17 ± 0.28 MBq),...
Abstract：Structural variation (SV) is a fundamental genetic cause for cancer, with demonstrated correlation to disease progression and treatment response. Traditional sequencing method cannot provide full genomic landscape especially large-scale complex structural variation. To overcome these limitations, we adopted combined approaches, including optical mapping, single molecular short reads shotgun sequencing, evaluate the SV in thyroid cancer. Different numbers, length types of variation,...
Soil fungi play a crucial role in soil microbes, the composition and variety of whose communities can be altered due to nitrogen constraints, thereby affecting plant’s development. This study aimed investigate relationship between communities, fertility index, structure fungal under varying fertilizer conditions, using long-term positioning test on brown earth Northeast China. It examined impact 31 years applying no (CK, 0 kg N hm−2 a−1), single application inorganic (N2, urea 135 a−1; N4,...