A5114348348- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- Plant-based Medicinal Research
- Clostridium difficile and Clostridium perfringens research
- Traditional Chinese Medicine Analysis
- Cellular Mechanics and Interactions
- Genital Health and Disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroscience and Neuropharmacology Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Advanced MRI Techniques and Applications
- Gastrointestinal disorders and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Adipose Tissue and Metabolism
- Apelin-related biomedical research
- Meningioma and schwannoma management
- Microbial Natural Products and Biosynthesis
- Microbial Metabolism and Applications
- Cardiovascular Disease and Adiposity
- Phagocytosis and Immune Regulation
- Lipoproteins and Cardiovascular Health
- Bacterial Genetics and Biotechnology
Binzhou Medical University
2016-2025
Binzhou University
2016-2025
Sichuan Cancer Hospital
2025
University of Electronic Science and Technology of China
2025
Southwest Medical University
2025
Shanghai Jiao Tong University
2023-2024
Yantai Institute of Coastal Zone Research
2023
Chinese Academy of Sciences
2023
Institute of Microbiology
2020
Center for Life Sciences
2020
Radiation-induced pulmonary fibrosis (RIPF) is a serious complication of radiotherapy that lacks effective treatment options. The Huaxian formula (HXF), traditional Chinese herbal remedy, shows promise in alleviating RIPF; however, its active ingredients and underlying mechanisms remain poorly understood. Through serum pharmacochemistry, network pharmacology, molecular docking, experimental validation, we investigate the potential HXF prevention radiation-induced (RIPF). Histological...
Chronic stress induces depression and insulin resistance, between which there is a bidirectional relationship. However, the mechanisms underlying this comorbidity remain unclear. White adipose tissue (WAT), innervated by sympathetic nerves, serves as central node in interorgan crosstalk through adipokines. Abnormal secretion of adipokines involved mood disorders metabolic morbidities. We describe here brain-sympathetic nerve-adipose circuit originating hypothalamic paraventricular nucleus...
Background Abnormal levels of glutamate constitute a key pathophysiologic mechanism in epilepsy. The use chemical exchange saturation transfer (GluCEST) imaging to measure pediatric epilepsy is rarely reported research. Purpose To investigate hippocampal level variations and the correlation between subregional volumes. Study Type Cross‐sectional, prospective. Subjects A total 38 school‐aged patients with structurally normal MRI as determined by at least two independent radiologists (60%...
Abstract The mechanically activated Piezo channel plays a versatile role in conferring mechanosensitivity to various cell types. However, how it incorporates its intrinsic and cellular components effectively sense long-range mechanical perturbation across remains elusive. Here we show that Piezo1 is biochemically functionally tethered the actin cytoskeleton via E-cadherin-β-catenin mechanotransduction complex, whose significantly impairs Piezo1-mediated responses. Mechanistically, adhesive...
Red blood cells (RBCs) are susceptible to sustained free radical damage during circulation, while the changes of antioxidant capacity and regulatory mechanism RBCs under different oxygen gradients remain unclear. Here, we investigated oxidative in identified underlying mechanisms using an vitro model hypoxanthine/xanthine oxidase (HX/XO) system. In present study, reported that hypoxic showed much higher stress injury lower compared with normoxic RBCs. addition, found disturbance recycling...
Abstract Epsilon toxin (ETX) is a 33‐kDa pore‐forming produced by type B and D strains of Clostridium perfringens . We previously found that ETX caused haemolysis human red blood cells, but not erythrocytes from other species. The cellular molecular mechanisms ETX‐mediated are well understood. Here, we investigated the effects on erythrocyte volume role putative myelin lymphocyte (MAL) receptors in haemolysis. observed initially decreased size, followed gradual increase until lysis....
In the lower respiratory tract, alveolar spaces are divided from bloodstream and external environment by only a few microns of interstitial tissue. Alveolar macrophages (AMs) defend this delicate mucosal surface invading infections regularly patrolling site. AMs have three behavior modalities to achieve goal: extending cell protrusions probe sample surrounding areas, squeezing whole body between alveoli, moving around each alveolus. study, we found Rho GTPase, division control protein 42...
Background and Aims: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs). However, the precise molecular mechanisms of Ngb action are largely unknown. Ras homolog (Rho) guanosine triphosphatases (Rho GTPases) involved regulation a number cellular processes, including cell cytotoxicity. It has been reported act as guanine nucleotide dissociation inhibitior (GDI) role to inactivate Rho...
The detoxified beta1–epsilon (β1–ϵ) toxin protein of Clostridium perfringens type B provides protection from C. types B, C and D infections. Acetate is the primary by-product cell growth expression β1–ϵ protein. In present study, effects pH dissolved oxygen (DO) on β1--ϵ were investigated. Two-stage DO control strategies developed for obtained results indicated that higher density concentration protein, lower accumulation acetate when was maintained at a constant level 6.5 (0–6 h) 7.0 (6–16...
Abstract Neutrophils are the most abundant immune cells that constantly patrol and marginate into vascular beds of multiple tissues to support homeostasis. The extent which neutrophils undergo adaptation in response diverse tissue microenvironments, resultant biological implications such adaptation, remains unclear. Here, we performed intravital imaging, transcriptional, functional analyses different tissues. Our findings showed lung harbors a transcriptionally distinct neutrophil population...
To investigate the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) on platelet activation in sepsis.(1) Clinical trial: a prospective study was conducted. Patients with sepsis and septic shock aged ≥ 18 years old who met diagnostic criteria Sepsis-3 admitted to department intensive care medicine Affiliated Hospital Binzhou Medical College from January October 2021 were selected as subjects. Healthy subjects same period taken healthy control group. Platelet count (PLT) first...