A5068778761- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanoparticle-Based Drug Delivery
- Asymmetric Synthesis and Catalysis
- Wastewater Treatment and Nitrogen Removal
- Blood properties and coagulation
- Lattice Boltzmann Simulation Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- Membrane Separation Technologies
- Catalytic C–H Functionalization Methods
- Polymer Surface Interaction Studies
- Asymmetric Hydrogenation and Catalysis
- Streptococcal Infections and Treatments
- Microfluidic and Bio-sensing Technologies
- Material Dynamics and Properties
- Oxidative Organic Chemistry Reactions
- Microbial Metabolic Engineering and Bioproduction
- Rheology and Fluid Dynamics Studies
- Synthetic Organic Chemistry Methods
- Polymer Nanocomposites and Properties
- Phase Equilibria and Thermodynamics
- Pickering emulsions and particle stabilization
- Nanomaterials for catalytic reactions
University of Science and Technology of China
2020-2025
Chinese Research Academy of Environmental Sciences
2014-2024
Lanzhou Institute of Chemical Physics
2009-2024
Chinese Academy of Sciences
2009-2024
Lanzhou University
2006-2024
Anhui Agricultural University
2024
State Key Laboratory of Oxo Synthesis and Selective Oxidation
2024
Oak Ridge National Laboratory
2021-2023
Ningbo University
2023
National Engineering Research Center of Electromagnetic Radiation Control Materials
2023
Using coarse-grained molecular dynamics simulations, we systematically investigate the receptor-mediated endocytosis of elastic nanoparticles (NPs) with different sizes, ranging from 25 to 100 nm, and shapes, including sphere-like, oblate-like, prolate-like. Simulation results provide clear evidence that membrane wrapping efficiency NPs during is a result competition between receptor diffusion kinetics thermodynamic driving force. The refer recruitment are affected by contact edge length NP...
The local delivery of gaseous signaling molecules (GSMs) has shown promising therapeutic potential. However, although GSMs have a subtle interplay in physiological and pathological conditions, the co-delivery different for purposes remains unexplored. Herein, we covalently graft nitric oxide (NO)-releasing N-nitrosamine moiety onto carbon monoxide (CO)-releasing 3-hydroxyflavone (3-HF) antenna, resulting first NO/CO-releasing donor. Under visible light irradiation, photo-mediated co-release...
Abstract Carbon monoxide (CO) is an important gaseous signaling molecule. The use of CO‐releasing molecules such as metal carbonyls enables the elucidation pleiotropic functions CO. Although show a broad‐spectrum antimicrobial activity, it remains unclear whether bactericidal property originates from transition metals or released Here, we develop nonmetallic micelles via photooxygenation mechanism 3‐hydroxyflavone derivatives, enabling CO release under red light irradiation (e.g., 650 nm)....
Abstract Nitric oxide (NO) serves as a key regulator of many physiological processes and potent therapeutic agent. The local delivery NO is important to achieve target outcomes due the toxicity at high concentrations. Although light stimulus represents non‐invasive tool with spatiotemporal precision mediate release, photoresponsive NO‐releasing molecules can only respond ultraviolet (UV) or near‐UV visible low penetration phototoxicity. We report that coumarin‐based donors maximal...
A palladium-catalyzed intramolecular hydroaminocarbonylation of 2-vinylbenzylamines in the absence acidic or any other additives was realized via rational designing catalytic system on basis mechanistic studies, which allows for synthesis a variety six-membered lactams good to excellent yields with high regioselectivity. The postulated palladium-hydride intermediate initiating has been identified and directly used as catalyst reaction. Further kinetic studies illustrated that reaction rate...
The aggregation of PEG polymers during the membrane wrapping process PEGylated liposomes can introduce a large free energy barrier, thereby limiting cellular uptake liposomes.
The selectively integrating electron and hole transfer layers into hematite reduce surface interface recombination for PEC water splitting performance.
Arbuscular mycorrhizal (AM) and ectomycorrhizal (EcM) associations are critical for host-tree performance. However, how correlate with the latitudinal tree beta-diversity remains untested. Using a global dataset of 45 forest plots representing 2,804,270 trees across 3840 species, we test AM EcM contribute to total its components (turnover nestedness) all trees. We find rather than predominantly decreasing turnover increasing nestedness latitude, probably because wide distributions do not...
A Michael-aldol reaction of 2-mercaptobenzaldehyde with β-indole-β-CF3 enones catalyzed by a squaramide has been realized. The method affords series 2-CF3-2-indole-substituted thiochromanes featuring CF3-containing quaternary stereocenter in excellent yields, diastereoselectivities, and enantioselectivities.
For nanoparticle (NP)-based drug delivery platforms, the elasticity of NPs has a significant influence on their blood circulation time and cellular uptake efficiency. However, due to complexity endocytosis process inconsistency in definition for experiments, understanding about receptor-mediated elastic is still limited. In this work, we developed coarse-grained molecular dynamics (CGMD) model NPs. The energy change can be precisely controlled by bond, area, volume bending potentials CGMD...
The β-isocupreidine, a cinchonine derived alkaloid, catalyzed asymmetric SN2′–SN2′ reaction between N-2,2,2-trifluoroethylisatin ketimines and MBH type carbonates was realized in simple efficient way. A series of chiral α-trifluoromethylamines were prepared with excellent yields stereoselectivities. subsequent easy process deprotection gave γ-trifluoromethyl-α-methylenelactam stereoselective manner.
Abstract The introduction of a trifluoromethyl group into the 2′‐position spiro‐pyrrolidine‐3,3′‐oxindoles is described. By using 1 mol% quinine‐derived squaramide as catalyst, 2,2,2‐trfluoroethylamine (CF 3 CH 2 NH )‐derived ketimine transformed initially trifluoromethylimine through an umpolung reaction. subsequent 1,3‐dipolar cycloaddition gives pharmaceutical important target compounds in excellent yields, enantioselectivities and diastereoselectivies. magnified image