A5032684202- Antimicrobial Peptides and Activities
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Environmental and Agricultural Sciences
- Fluorine in Organic Chemistry
- Genetic and Kidney Cyst Diseases
- Asymmetric Synthesis and Catalysis
- Rice Cultivation and Yield Improvement
- Biochemical and Structural Characterization
- Renal and related cancers
- Forest, Soil, and Plant Ecology in China
- Tea Polyphenols and Effects
- Soil Carbon and Nitrogen Dynamics
- RNA Interference and Gene Delivery
- Chemical Synthesis and Analysis
- Advancements in Battery Materials
- Polydiacetylene-based materials and applications
- Neuropeptides and Animal Physiology
- Genetic Syndromes and Imprinting
- Electrospun Nanofibers in Biomedical Applications
- Environmental Changes in China
- Gestational Diabetes Research and Management
- Synthesis and Catalytic Reactions
- Antimicrobial agents and applications
- Phytochemicals and Antioxidant Activities
Lanzhou University
2016-2025
Hunan University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Lanzhou Veterinary Research Institute
2022-2023
Ningxia Medical University
2008-2022
Lanzhou City University
2015-2021
Ningbo Science and Technology Bureau
2020
Qingdao Agricultural University
2008-2019
Fudan University
2019
Erasmus MC
2019
It has been an outstanding challenge to achieve implantable energy modules that are mechanically soft (compatible with organs and tissues), have compact form factors, biodegradable (present for a desired time frame power biodegradable, medical electronics). Here, we present fully bioabsorbable high-performance supercapacitor implant, which is lightweight thin structure, mechanical flexibility, tunable degradation duration, biocompatibility. The high areal capacitance (112.5 mF cm-2 at 1 mA...
Postoperative adhesion is a common complication of abdominal surgery, which always has many adverse effects in patients. At present, there still lack effective treatment measures and materials to prevent the clinics. Herein, we report potential use J-1-ADP hydrogel formed by natural antimicrobial peptide jelleine-1 (J-1) self-assembling adenosine diphosphate (ADP) sodium solution postsurgery formation. was found have good activity against bacteria fungi tested can be used tissue infection,...
To elucidate the molecular pathways that modulate renal cyst growth in ADPKD, we performed global gene profiling on cysts of different size (<1 ml, n = 5; 10-20 >50 3) and minimally cystic tissue (MCT, 5) from five PKD1 human polycystic kidneys using Affymetrix HG-U133 Plus 2.0 arrays. We used set enrichment analysis to identify overrepresented signaling key transcription factors (TFs) between MCT. found down-regulation kidney epithelial restricted genes (e.g. nephron segment-specific...
The clinical use of conventional ultrasonography (US) in autosomal dominant polycystic kidney disease (ADPKD) is currently limited by reduced diagnostic sensitivity, especially at-risk subjects younger than 30 years age. In this single-center prospective study, we compared the performance MRI with that high-resolution (HR) US 126 ages 16–40 born a 50% risk ADPKD who underwent both these renal imaging studies and comprehensive PKD1 PKD2 mutation screening. Concurrently, 45 healthy control...
Renal disease variability in autosomal dominant polycystic kidney (ADPKD) is strongly influenced by the gene locus ( PKD1 versus PKD2 ). Recent studies identified nontruncating mutations approximately 30% of patients who underwent comprehensive mutation screening, but clinical significance these not well defined. We examined genotype-renal function correlation a prospective cohort 220 unrelated ADPKD families ascertained through probands with serum creatinine ≤1.4 mg/dl at recruitment....
A new strategy for the construction of optically active 5'-CF3 spiro[pyrrolidin-3,2'-oxindole] was described. series unprecedented 1,3-dipoles were obtained by condensation CF3CH2NH2 with isatins. The 1,3-dipolar cycloaddition reactions these ketimines enals gave products bearing four contiguous stereogenic centers in excellent yields, diastereoselectivities and enantioselectivities.
The extensive use and misuse of antibiotics in medicine result the emergence multidrug-resistant bacteria, creating an urgent need for development new chemotherapeutic agents. Nowadays, antimicrobial peptides are widely recognized as a class promising candidates with activity against bacteria. NK-18 is truncated peptide derived from NK-Lysin, effector cytotoxic T cells natural killer cells. In this study, we studied antibacterial mechanism action NK-18. results revealed that has potent...
Antimicrobial peptide has the potential to be developed as new kind of antimicrobial agents with novel action mechanism. However, susceptibility protease is a drawback for peptides clinical used. d-amino acid substitution can one way increase proteolytic stability peptides. In present study, we synthesized d-lysines substituted analog (d-lys-MPI) and d-enantiomer polybia-MPI (D-MPI) improve resistance polybia-MPI. Our results showed that, its partially d-lys-MPI was increased. it lost...
With the increasing emergence of resistant microbes toward conventional antimicrobial agents, there is an urgent need for development agents with novel action mode. Antimicrobial peptides (AMPs) are believed to be one kind ideal alternatives. However, AMPs can easily degraded by protease, which limited their therapeutic use. In present study, D-amino acid substitution strategy was employed enhance stability polybia-CP. We investigated against degradation trypsin and chymotrypsin determining...
Abstract A Cinchona alkaloid‐derived squaramide‐catalyzed asymmetric cycloaddition of trfluoromethyl‐containing azomethine ylides with β‐nitroalkenes was realized under mild conditions. series biologically important 5′‐trifluoromethyl‐ spiro[pyrrolidin‐3,2′‐oxindoles] synthesized efficiently by this process in excellent yields, enantioseletivities and diastereoselectivities. magnified image
The absence of a positive family history (PFH) in 10%–25% patients poses diagnostic challenge for autosomal dominant polycystic kidney disease (ADPKD). In the Toronto Genetic Epidemiology Study Polycystic Kidney Disease, 210 affected probands underwent renal function testing, abdominal imaging, and comprehensive PKD1 PKD2 mutation screening. From this cohort, we reviewed all with without an apparent history, examined their parental medical records, performed imaging available parents unknown...
The Na-site coordination environment of the Na 4 MnV(PO ) 3 cathode is regulated for first time largely improving electrochemical properties via K + doping.
Abstract. An intriguing feature of autosomal dominant polycystic kidney disease (ADPKD) is the focal and sporadic formation renal extrarenal cysts. Recent documentation somatic PKD1 mutations in cystic epithelia patients with germ-line suggests a “two-hit” model for cystogenesis type 1 ADPKD. This study tests whether same mechanism might also occur 2 Genomic DNA was obtained from 54 liver cysts three known PKD2 mutations, using procedures that minimize contamination cells noncystic tissue....
ABSTRACT. Autosomal dominant polycystic kidney disease (ADPKD) is a common Mendelian disorder that affects approximately 1 in 1000 live births. Mutations of two genes, PKD1 and PKD2, account for the 80 to 85% 10 15% cases, respectively. Significant interfamilial intrafamilial renal variability ADPKD has been well documented. Locus heterogeneity major determinant (i.e., patients from PKD1-linked families have significantly earlier onset ESRD compared with PKD2-linked families). More recently,...
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and an important cause of ESRD. Familial clustering cases suggests genetic predisposition to this disease. Two recent genome-wide studies in IgAN have identified a major susceptibility locus on chromosome 6q22 (IGAN1) two additional loci with suggestive linkage signals chromosomes 4q26-31 17q12-22. A large four-generation family 14 affected individuals has been clinically ascertained excluded from these loci. scan was...
TP10–5 (TK) was screened as the most promising candidate among designed analogues of transportan 10 (TP10), a cell penetrating peptide (CPP) with remarkable capacity for membrane translocation. However, low levels specificity and high toxicity limit its successful use drug delivery applications. Here, we developed new type acid-activated CPP (TH) by replacement all lysines TK histidines. As expected, histidine-containing TH can be activated subsequently enter cells at pH 6.0, whereas it is...
Abstract An organocatalytic enantioselective Strecker reaction for the synthesis of 3‐amino‐3‐cyanooxindoles has been developed. Employing a quinine‐derived thiourea catalyst, nucleophilic addition trimethylsilyl cyanide to N ‐Boc‐ketimines affords 3‐amino‐3‐canooxindoles in good excellent yields (78–98%) and very enantioselectivities (up 94%). Furthermore, best our knowledge, this method also represents first organocatalyzed with as electrophiles.