A5100354546- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Dermatology and Skin Diseases
- Actinomycetales infections and treatment
- Advanced Photocatalysis Techniques
- Antimicrobial Peptides and Activities
- Cancer Genomics and Diagnostics
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Catalytic Processes in Materials Science
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Cancer Risks and Factors
- Catalysis and Oxidation Reactions
- Gas Sensing Nanomaterials and Sensors
- Bariatric Surgery and Outcomes
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Catalysts for Methane Reforming
- Diet and metabolism studies
Northwestern Polytechnical University
2025
Fudan University Shanghai Cancer Center
2020-2024
Fudan University
2020-2024
Shanghai Medical College of Fudan University
2020-2024
State Key Laboratory of Genetic Engineering
2023
Chinese PLA General Hospital
2023
Lanzhou University
2015-2019
Dongguan People’s Hospital
2007-2014
Guangzhou Institute of Dermatology
2012
Abstract The introduction of a trifluoromethyl group into the 2′‐position spiro‐pyrrolidine‐3,3′‐oxindoles is described. By using 1 mol% quinine‐derived squaramide as catalyst, 2,2,2‐trfluoroethylamine (CF 3 CH 2 NH )‐derived ketimine transformed initially trifluoromethylimine through an umpolung reaction. subsequent 1,3‐dipolar cycloaddition gives pharmaceutical important target compounds in excellent yields, enantioselectivities and diastereoselectivies. magnified image
We present in this work a synergetic modulation strategy on electronic structure and surface properties, which achieves 88.24% selectivity of dehydrogenation the C–H bond.
The misuse and overuse of antibiotics result in the emergence resistant bacteria fungi, which make an urgent need new antimicrobial agents. Nowadays, peptides have attracted great attention researchers. However, low physiological stability biological system limits application naturally occurring as novel therapeutics. In present study, we synthesized derivatives protonectin by substituting all amino acid residues or cationic lysine residue with corresponding D-amino acids. Both D-enantiomer...
The incidence of life‐threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides a class potential lead chemical for development novel agents. peptide polybia‐CP was purified from venom social wasp Polybia paulista . In this study, we synthesized and determined its effects against series Candidian species. Our results showed that has potent activity fungicidal tested cells with proposed...
We comprehensively investigated the morphology patterns of lung cancers associated with cystic airspaces. Our goal was to determine predictive value imaging features in a clinical environment.We collected information about patients resected airspaces from January 2010 December 2019. Radiological features, clinicopathological characteristics, gene mutations and survival data were analysed comprehensively.A total 384 identified categorized as 4 types: I, thin-wall type (n = 31, 8.1%); II,...
We aimed to describe accurately the timing and site-specific recurrence pattern for surgical resected lung adenocarcinoma develop genetic-pathological risk prediction models guide individual postoperative surveillance strategies.We retrospectively analysed radiological, pathological sequencing data concerning 9 common oncogenic driver mutations from 1531 patients with between 2008 2015. The first site time-to-recurrence were recorded. Independent factors identified by multivariable...
Ischemic precondition plays a protective effect during cerebral ischemia. This partly depends on the autophagic activity. However, whether activity of autophagy can exert effects after ischemia is unclear. In this study, rats were treated with spermidine, an activator autophagy, and injected sodium laurate via internal carotid artery to stimulate small vessel disease (CSVD). The spermidine brain injury evaluated by behavioural test, histology assay, ultrastructure observation,...
Background The overall 5-year survival of lung cancer was reported to be only ~15%, with adenocarcinoma (LUAD) as the main pathological subtype. Before developing into invasive stages, LUAD undergoes pre-invasive stages in situ (AIS) and minimally (MIA), where surgical resection gives an excellent rate. Given dramatic decline prognosis from a deeper understanding key molecular changes driving progression is highly needed. Methods In this study, we performed whole-exome sequencing RNA on...
Filaggrin (FLG) plays an important role in the epidermal barrier function, which identified patients with ichthyosis vulgaris(IV).To study genetics of FLG mutations Southern Chinese IV. We evaluated influence five (3321 delA, 441delA, 1249 insG, E1795X and S3296X) a cohort 65 IV 100 control individuals using Sequenom® MassARRAY® system. The null allele frequency 3321delA was 52.31%(34/65). mutation 441delA only found one patients. 1249insG, S3296X were not these These findings show that...