A5068676041- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Multiple and Secondary Primary Cancers
- Actinomycetales infections and treatment
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Peptidase Inhibition and Analysis
- Cancer Risks and Factors
- Meningioma and schwannoma management
- Inflammatory Biomarkers in Disease Prognosis
- Pleural and Pulmonary Diseases
- Medical Imaging Techniques and Applications
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Pain Mechanisms and Treatments
Fudan University Shanghai Cancer Center
2020-2025
Fudan University
2020-2024
Shanghai Medical College of Fudan University
2020-2024
We aimed to prospectively evaluate our previously proposed selective mediastinal lymph node (LN) dissection strategy for peripheral clinical T1N0 invasive NSCLC.This is a multicenter, prospective trial in China. set six criteria predicting negative LN stations and finally guiding dissection. Consolidation tumor ratio less than or equal 0.5, segment location, lepidic-predominant adenocarcinoma (LPA), hilar nodes (stations 10-12), visceral pleural invasion (VPI) were used separately...
Lung adenocarcinoma follows a stepwise progression from pre-invasive to invasive. However, there remains knowledge gap regarding molecular events Here, we conduct comprehensive proteogenomic analysis comprising whole-exon sequencing, RNA and proteomic phosphoproteomic profiling on 98 99 invasive lung adenocarcinomas. The deletion of chr4q12 contributes the by downregulating SPATA18, thus suppressing mitophagy promoting cell invasion. Proteomics reveals diverse enriched pathways in normal...
Background: Despite recent progresses in immune checkpoint blockade (ICB) small-cell lung cancer (SCLC), a lack of understanding regarding the systemic tumor environment (STIE) and local microenvironment (TIME) makes it difficult to accurately predict clinical outcomes identify potential beneficiaries from ICB therapy.
Immune function is a key component affecting tumor progression in patients with cancer. The purpose of this study was to identify the prognostic value systemic immune-inflammation index (SII) non-small cell lung cancer (NSCLC) and differences its distinct characteristics.Patients completely resected NSCLC were reviewed according eighth TNM classification Patients further categorized into low- high-SII groups. Cox proportional hazard analyses performed independent factors.A total 3984...
Objective: To investigate the value of intraoperative assessment spread through air spaces (STAS) on frozen sections (FS) in peripheral small-sized lung adenocarcinoma. Background: Surgical decision-making based FS diagnosis STAS may be useful to prevent local control failure after sublobar resection. Methods: We conducted a multicenter prospective observational study consecutive patients with cT1N0M0 invasive adenocarcinoma evaluate accuracy for detection STAS. The final pathology (FP) was...
Currently, programmed death ligand-1 (PD-L1) expression has been widely applied in clinical trials and real-world practice as a major biomarker for the efficacy of immune-checkpoint inhibitors. The purpose this study is to reveal distribution concordance PD-L1 large-scale consecutive cohort from East-Asian patients with non-small cell lung cancer (NSCLC).PD-L1 testing was conducted using 22C3 assays, cases were categorized into high, low, no based on tumor proportion score (TPS)....
Complex glandular pattern (CGP) was included as high-grade in the new grading system proposed by The International Association for Study of Lung Cancer. We aimed to investigate mutational profile and validate prognostic significance proper cut-off value distinguish aggressive behavior CGP.CGP defined nests tumor cells with sieve-like perforation, fused glands irregular borders or back-to-back without intervening stroma. Patients were categorized into four groups according percentage CGP...
Background: This study aims to assess the diagnostic accuracy of intraoperative frozen section (FS) in determining pathological subtypes among patients diagnosed with cT1N0M0 invasive lung adenocarcinoma. Materials and methods: was a prospective, multicenter (seven centers China) clinical trial Eastern Cooperative Thoracic Oncology Projects (ECTOP-1015). Patients adenocarcinoma were enrolled study. Pathological images obtained from FS final pathology (FP) reviewed by at least two...
We aimed to describe accurately the timing and site-specific recurrence pattern for surgical resected lung adenocarcinoma develop genetic-pathological risk prediction models guide individual postoperative surveillance strategies.We retrospectively analysed radiological, pathological sequencing data concerning 9 common oncogenic driver mutations from 1531 patients with between 2008 2015. The first site time-to-recurrence were recorded. Independent factors identified by multivariable...
Background The overall 5-year survival of lung cancer was reported to be only ~15%, with adenocarcinoma (LUAD) as the main pathological subtype. Before developing into invasive stages, LUAD undergoes pre-invasive stages in situ (AIS) and minimally (MIA), where surgical resection gives an excellent rate. Given dramatic decline prognosis from a deeper understanding key molecular changes driving progression is highly needed. Methods In this study, we performed whole-exome sequencing RNA on...
Abstract Despite recent progress in subtype classification for small cell lung carcinoma (SCLC), little is known about the biomarker triple‐negative (ASCL1, NEUROD1, and POU2F3 negative) tumors. The long‐term survival, adjuvant chemotherapy (ACT) response, immune milieu different SCLC subtypes have also not been well established. Here, we retrospectively collected a large cohort of 192 primary tumors reported that ASCL1‐, NEUROD1‐ POU2F3‐dominant counted 61.38%, 19.31%, 6.21%, respectively....