A5100372106- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Multiple Myeloma Research and Treatments
- Cardiac Ischemia and Reperfusion
- Tuberous Sclerosis Complex Research
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Tissue Engineering and Regenerative Medicine
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Radiopharmaceutical Chemistry and Applications
- AI in cancer detection
- Cancer Cells and Metastasis
- Cardiac Fibrosis and Remodeling
- Peptidase Inhibition and Analysis
- Histiocytic Disorders and Treatments
- HER2/EGFR in Cancer Research
- BRCA gene mutations in cancer
- Medical Imaging and Analysis
Fudan University Shanghai Cancer Center
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Zhongshan Hospital
2023-2025
Fudan University
2023-2025
Sun Yat-sen University
2023-2025
Xuzhou Medical College
2024
Shanghai Medical College of Fudan University
2015-2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Shanghai Cancer Institute
2022-2023
Abstract As a cell proliferation biomarker, Ki-67 is principally used in ER+/HER2− breast cancer. However, the importance and best cutoff point of triple-negative cancer (TNBC) remains unclear was evaluated this study.A total 1800 patients with early invasive TNBC between 2011 2016 at Fudan University Shanghai Cancer Center were consecutively recruited for study. The optimal assessed by Cutoff Finder. Propensity score matching (PSM, ratio = 1:2) performed to match low group high group....
Abstract Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare type of kidney cancer, which not well characterized. Here we show the comprehensive proteogenomic analysis tRCC tumors and normal adjacent tissues to elucidate molecular landscape this disease. Our study reveals that defective DNA repair plays an important role in carcinogenesis progression. Metabolic processes are markedly dysregulated at both mRNA protein levels. Proteomic...
Digital histopathology image segmentation can facilitate computer-assisted cancer diagnostics. Given the difficulty of obtaining manual annotations, weak supervision is more suitable for task than full is. However, most weakly supervised models are not ideal handling severe intra-class heterogeneity and inter-class homogeneity in images. Therefore, we propose a novel end-to-end learning framework named WESUP. With only sparse point it performs accurate exhibits good generalizability. The...
<title>Abstract</title> Gemcitabine resistance is a critical factor contributing to the recurrence and progression of bladder cancer. In this study, we utilized high-throughput drug screening cancer organoid models identify Bavachalcone (Bava) as sensitizing agent for gemcitabine, thereby inhibiting Bava targets transferrin receptor (TFRC) epidermal growth (EGFR), competitively binding TFRC with (Tf), which reduces influx iron ions activity mitochondrial respiratory chain complexes....
Lactate dehydrogenase (LDH) is an enzyme involved in anaerobic glycolysis and associated with the prognosis of patients renal cell carcinoma (RCC). The human genome has four LDH genes: LDHA, LDHB, LDHC LDHD. In order to determine which these genes may predict clear RCC (ccRCC), a total 509 ccRCC from Cancer Genome Atlas (TCGA) cohort 192 Fudan University Shanghai Centre (FUSCC) were enrolled present study. expression profiles LDHD TCGA obtained RNAseq database. Cox proportional hazards...
Abstract The tyrosine kinase inhibitor (TKI) Sunitinib is one the therapies approved for advanced renal cell carcinoma. Here, we undertake proteogenomic profiling of 115 tumors from patients with clear carcinoma (ccRCC) undergoing treatment and reveal molecular basis differential clinical outcomes TKI therapy. We find that chromosome 7q gain-induced mTOR signaling activation associated poor therapeutic treatment, whereas aristolochic acid signature VHL mutation synergistically caused...
// Kun Chang 1,2,* , Yun-Yi Kong 2,3,* Bo Dai 1,2 Ding-Wei Ye Yuan-Yuan Qu Yue Wang Zhong-Wei Jia and Gao-Xiang Li 1 Department of Urology, Fudan University Shanghai Cancer Center, University, Shanghai, China 2 Oncology, Medical College, 3 Pathology, * Co-first author Correspondence to: Dai, email: Ye, Keywords : circulating tumor cell, epithelial-mesenchymal transition, metastatic castration-resistant prostate cancer, prognosis, stem cell Received August 05, 2015 Accepted October 04,...
Androgen deprivation therapy (ADT) is the standard of care for patients with metastatic prostate cancer. However, whether serum testosterone levels, using a cut-off point 50 ng dl−1, are related to effective time ADT in newly diagnosed cancer remains controversial. Moreover, recent studies have shown that some may benefit from addition upfront docetaxel chemotherapy. To date, no been able distinguish who will combination and This study included 206 were showed progression castrate-resistance...
Chemokines are involved in many aspects of oncogenesis, including regulation cancer cell growth, dissemination and host-tumor response. However, the potential chemokine receptors, CXCR4 CXCR7, serving as biomarkers extramammary Paget's disease (EMPD) has been rarely examined. Expressions CXCR7 were evaluated 92 EMPD specimens by immunohistochemistry. High expression both correlated with regional lymph node metastasis presence lymphovascular invasion. also depth The prognostic value these two...
The nudix hydroxylase (NUDT) family of genes may have notable roles in cancer growth and metastasis. present study aimed to determine the prognostic ability NUDT clear cell renal carcinoma (ccRCC). Data from 509 patients with ccRCC was obtained Cancer Genome Atlas (TCGA) database 192 patient samples Fudan University Shanghai Center (FUSCC) were analyzed study. expression profile gene members TCGA cohort RNA sequencing database. Pathological characteristics, including age, sex, tumor size,...
Objectives To identify biomarkers that predict the response to standard androgen deprivation therapy (ADT) of patients newly diagnosed with metastatic castration‐sensitive prostate cancer (CSPC) in order improve therapeutic decision‐making, and investigate whether characterization baseline circulating tumour cells (CTCs) would effective period ADT. Materials Methods The study included 108 high‐volume CSPC. Enumeration patients’ CTCs (CTCs+ CTCs−, indicating detectable undetectable CTCs,...
Stem cell-based therapies offer promising potential for myocardial infarction (MI), but endogenous molecules released in response to injury likely impair posttransplantation stem cell function. cell-mediated cardioprotection occurs part via paracrine effects, and transforming growth factor-alpha (TGF-alpha) has been shown enhance However, it is unknown whether pretreating cells with TGF-alpha increases after acute MI. Mesenchymal (MSCs) were treated (250 ng/ml) 24 h. Adult male...
Abstract Objectives Intratumor heterogeneity (ITH) is an important factor for clinical outcomes in patients with multiple myeloma (MM). High ITH has been proven to be a key reason tumor immune escape and treatment resistance. Neoantigens are thought associated ITH, but the specific correlation functional basis this remains unclear. Methods We study question through whole‐exome sequencing (WES) data from 43 high newly diagnosed MM our center. Mutant allele (MATH) was conducted quantify ITH....
Abstract Despite recent progress in subtype classification for small cell lung carcinoma (SCLC), little is known about the biomarker triple‐negative (ASCL1, NEUROD1, and POU2F3 negative) tumors. The long‐term survival, adjuvant chemotherapy (ACT) response, immune milieu different SCLC subtypes have also not been well established. Here, we retrospectively collected a large cohort of 192 primary tumors reported that ASCL1‐, NEUROD1‐ POU2F3‐dominant counted 61.38%, 19.31%, 6.21%, respectively....
This study investigated the clinical activity of abiraterone plus prednisone in docetaxel-naïve and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer (mCRPC). A total 146 group (103 cases) (43 were enrolled from Shanghai Cancer Center (Shanghai, China) this retrospective cohort study. The efficacy endpoints prostate-specific antigen response rate, progression-free survival, clinical/radiographic overall survival to prednisone. Significantly higher rate...
To establish the safety and efficacy of gantry-mounted linear accelerator-based stereotactic body radiation therapy (SBRT) for low- intermediate-risk prostate cancer.We pooled 921 patients enrolled on 7 single-institution prospective phase II trials gantry-based SBRT from 2006 to 2017. The cumulative incidences biochemical recurrence (defined by Phoenix definition) physician-scored genitourinary (GU) gastrointestinal (GI) toxicities per original using Common Terminology Criteria Adverse...
Abstract In clear cell renal carcinoma (ccRCC), glycolysis is enhanced mainly because of the increased expression key enzymes in glycolysis. Hence, discovery new molecular biomarkers for may help guide and establish a precise system diagnosis treatment ccRCC. Expression profiles 1079 tumor samples ccRCC patients (including 311 treated with everolimus or nivolumab) were downloaded from public databases. Proteomic 232 obtained Fudan University Shanghai Cancer Center (FUSCC). Biological...