A5062337308- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Pulmonary Hypertension Research and Treatments
- Adrenal and Paraganglionic Tumors
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Metabolism, Diabetes, and Cancer
- Tissue Engineering and Regenerative Medicine
- Radiopharmaceutical Chemistry and Applications
- Infectious Encephalopathies and Encephalitis
- Cardiovascular Health and Risk Factors
- Macrophage Migration Inhibitory Factor
- Mentoring and Academic Development
- Heat shock proteins research
- Apelin-related biomedical research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Traditional Chinese Medicine Studies
- Genomic variations and chromosomal abnormalities
- Renin-Angiotensin System Studies
- Innovative Teaching Methods
Fujian Medical University
2013-2024
First Affiliated Hospital of Fujian Medical University
2022-2024
Guangzhou Medical University
2024
Fudan University Shanghai Cancer Center
2021-2023
Hangzhou Children's Hospital
2023
Fudan University
1992-2022
State Key Laboratory of Genetic Engineering
2021-2022
Zhongshan Hospital
2022
Union Hospital
2021
Affiliated Hospital of Nantong University
2021
Abstract Clear cell renal carcinoma (ccRCC) is a common and aggressive subtype of cancer. Here we conduct comprehensive proteogenomic analysis 232 tumor adjacent non-tumor tissue pairs from Chinese ccRCC patients. By comparing with tissues, find that shows extensive metabolic dysregulation an enhanced immune response. Molecular subtyping classifies tumors into three subtypes (GP1–3), among which the most GP1 exhibits strongest phenotype, increased metastasis, imbalance, linking...
Abstract Chemotherapy and targeted therapy are the major treatments for gastric cancer (GC), but drug resistance limits its effectiveness. Here, we profile proteome of 206 tumor tissues from patients with GC undergoing either chemotherapy or anti-HER2-based therapy. Proteome-based classification reveals four subtypes (G-I–G-IV) related to different clinical molecular features. MSI-sig high benefit docetaxel combination treatment, accompanied by anticancer immune response. Further study T...
Abstract Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare type of kidney cancer, which not well characterized. Here we show the comprehensive proteogenomic analysis tRCC tumors and normal adjacent tissues to elucidate molecular landscape this disease. Our study reveals that defective DNA repair plays an important role in carcinogenesis progression. Metabolic processes are markedly dysregulated at both mRNA protein levels. Proteomic...
Toll-like receptor 4 (TLR4)-tumor necrosis factor 6 (TRAF6) signaling is activated in atherosclerosis (AS), inducing inflammatory mediators. Because miR-146a, a TLR4 microRNA (miRNA), can regulate during responses, this study investigated the effects of aerobic exercise on TLR4-targeted miRNAs AS. Apolipoprotein E-null mice fed high-fat diet for 12 weeks were separated into 3 groups: (i) no treatment (ii) statin (AD), or (iii) (AE). Plaques and foam cells observed untreated control groups,...
Eosinophilic pleural effusion constitutes a captivating and salient subject for exploration. In order to find out the reasons behind formation of eosinophilic effusion, we chose this study, hoping gradually unravel its mysterious veil. The absolute value percentage eosinophils in healthy people (normal control group), peripheral blood patients, patients were compared analyze their characteristics. with level was significantly greater than that group) (p < 0.0001) as well, even within...
Abstract Background: Gastrointestinal (GI) cancers, including esophageal squamous cell carcinoma (ESCC), colorectal cancer (CRC) and stomach adenocarcinoma (STAD), contribute to nearly one-third of cancer-related deaths in China. The late-stage diagnosis these cancers is largely due limited access endoscopic procedures low screening adherence. A blood-based multi-cancer early detection (MCED) test offers a more convenient alternative; however, the efficacy detecting early-stage remains...
Abstract The tyrosine kinase inhibitor (TKI) Sunitinib is one the therapies approved for advanced renal cell carcinoma. Here, we undertake proteogenomic profiling of 115 tumors from patients with clear carcinoma (ccRCC) undergoing treatment and reveal molecular basis differential clinical outcomes TKI therapy. We find that chromosome 7q gain-induced mTOR signaling activation associated poor therapeutic treatment, whereas aristolochic acid signature VHL mutation synergistically caused...
To identify liquid-liquid phase separation (LLPS)-related molecular clusters, and to develop validate a novel index based on LLPS for predicting the prognosis of prostate cancer (PCa) patients. We download clinical transcriptome data PCa from TCGA GEO database. The LLPS-related genes (LRGs) were extracted PhaSepDB. Consensus clustering analysis was used subtypes PCa. LASSO cox regression performed establish biochemical recurrence (BCR)-free survival (BCRFS). Preliminary experimental...
Insulin resistance (IR) plays a key role in the development of type 2 diabetes mellitus (T2DM) and is one its most important characteristics. Previous studies have shown that IR T2DM were independent risk factors for variety cardiovascular cerebrovascular diseases. However, there are few on relationship between aortic dissection (AD). The goal this research was to find evidence promotes occurrence AD.Through statistical analysis, we determined proportion glycosylated hemoglobin (HbA1c)...
Infusing undergraduate curricula with authentic research training is an important contemporary challenge. Such exposure typically occurs through mentored (MR) or course-based experiences (CUREs). In Asian contexts, CURE implementation rare, while MR often a graduation requirement. this study, mentor interviews and mentee focus groups were used to characterize the learning challenges associated requirement at Chinese university. An intensive 6-week was then implemented as preparatory program...
To explore the influencing factors of kinesiophobia and to establish a nomogram prediction model.
ABSTRACT Background: Accurate staging of prostate cancer (PCa) is the basis for risk stratification to select targeted treatment. Therefore, this study aimed compare diagnostic accuracy rates magnetic resonance imaging (MRI) and digital rectal examination (DRE) preoperative T potentially resectable PCa. Methods: From March 2021 2022, patients with PCa by biopsy were included. All examinations used postoperative histopathologic as reference standard. underwent DRE MRI before puncture. Two...
Increasing evidence indicates that DNA polymerase epsilon (POLE), which mediates damage repair, is significantly associated with tumor prognosis. This study aimed to analyze POLE expression in samples and its prognostic value for patients clear cell renal carcinoma (ccRCC). We found elevated ccRCC tissues compared normal of multiple independent cohorts. The levels 523 (The Cancer Genome Atlas RNA-seq data) 179 immunohistochemical data (Fudan University Shanghai Center) were analyzed...
Background: This study investigated serum Glucose transporter (GLUT) 4 levels and examined the relationship between GLUT4 sepsis in critically ill children. Methods: was a retrospective of 77 children 33 non-diabetic healthy (controls) who were admitted 07/2015 05/2016. Patient data, clinical information, blood samples collected on admission, alongside large number laboratory parameters that routinely assessed. Critically patients divided into non-sepsis/systemic inflammatory response...
This study aims to explore the role of cuproptosis-related genes in ACC, utilizing data from TCGA and GEO repositories, develop a predictive model for patient stratification.
Background: TBL1XR1 , also known as IRA1 or TBLR1 encodes a protein that is localized in the nucleus and expressed most tissues. binds to histones H 2 B 4 vitro functions nuclear receptor-mediated transcription. involved regulation of Wnt–β-catenin signaling pathway. Mutations gene impair pathway’s ability recruit Wnt-responsive element chromatin, affecting brain development. this cause various clinical phenotypes, including Pierpont syndrome, autism spectrum disorder, speech motor delays,...
目的 探讨儿童伴胼胝体压部可逆性病变的轻度脑炎/脑病(MERS)的临床特点。 方法 对在我院住院的5例MERS患儿进行回顾性分析，对其病因、临床表现、头颅影像学检查、治疗及随访进行总结分析。 结果 5例患儿中，发病年龄1岁6个月～6岁，平均年龄3.1岁，均有前驱感染史，3例以消化道症状起病，2例以呼吸道症状起病，5例均有不同程度的倦怠、嗜睡，4例抽搐，1例有头痛及共济失调。5例患儿血电解质、血渗透压、血糖、肝肾功能检查均正常。病原学检查轮状病毒感染3例，肺炎支原体感染2例，其中1例肺炎支原体感染合并流感病毒B感染。脑脊液检查4例正常，1例细胞数、蛋白轻度升高。脑电图检查2例呈背景弥漫性慢活动，3例正常。头颅MRI表现胼胝体压部片状T1WI稍低信号，T2WI稍高信号，DWI高信号影，其中1例同时伴有双侧半卵圆中心斑片状DWI高信号影，1～3周后复查均提示异常信号减低或消失。随访半年至2年，所有患儿均未发现神经系统后遗症。 结论 儿童MERS发病多与感染有关，临床症状轻微，头颅MRI有特征性表现，多数预后良好。