A5101912079- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Galectins and Cancer Biology
- Metastasis and carcinoma case studies
- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- Cancer-related gene regulation
- Flavonoids in Medical Research
- Breast Cancer Treatment Studies
- Medical Imaging and Analysis
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
- Angiogenesis and VEGF in Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Protease and Inhibitor Mechanisms
XinHua Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Zhengzhou Children's Hospital
2024
Zhengzhou University
2024
Tianjin Medical University Cancer Institute and Hospital
2021-2023
Tianjin Chest Hospital
2023
Tianjin University
2023
China Medical University
2021
Ruijin Hospital
2018-2021
Kanazawa University
2013
Prohibitin (PHB), a pleiotropic protein overexpressed in several tumor types, has been implicated the regulation of cell proliferation, invasive migration and survival. However, PHB expression its biological function gallbladder cancer (GBC) remain largely unknown. p-ERK expressions were determined human GBC tissues by immunohistochemistry (IHC). The effects knockdown on proliferation invasiveness evaluated using Cell Counting Kit-8 (CCK-8) viability, cycle analysis, transwell invasion...
Extensive evidence implicates the Eph receptor family of tyrosine kinases and its ligand, ephrin, in glioma invasion, but it remains incompletely understood how these receptors affect chemotactic behavior glioma. We sought to identify members that correlate with patients' survival reveal function invasion. Clinical relevance EphB genes was confirmed a clinically annotated expression data set 195 brain biopsy specimens. The analyzed vitro vivo. Levels mRNA certain were significantly different...
Gallbladder carcinoma (GBC) is the most common malignancy of bile duct and patients with GBC have extremely poor prognoses. PIK3CA, which encodes phosphoinositide 3-kinase (PI3K) subunit p110α, frequently mutated in many cancers, including GBC. The function E545K mutation not fully understood. was determined human tissues by targeted sequencing. effects PI3K selective inhibitor, A66 on cells were evaluated using Cell Counting Kit-8 (CCK-8) cell Viability transwell assays. mechanisms analyzed...
Background: Gallbladder cancer (GBC) is an aggressive and highly lethal biliary tract malignancy, with extremely poor prognosis. In the present study, we analyzed potential involvement of MYBL2, a member Myb transcription factor family, in carcinogenesis human GBC. Methods: MYBL2 expression levels were measured GBC cholecystitis tissue specimens using quantitative real-time PCR (qRT-PCR) immunohistochemical (IHC) assays. The effects on cell proliferation DNA synthesis evaluated Cell Counting...
Background: Copper as phytonutrient has powerful activity against health diseases. A newly discovered mechanism of cell death that affects energy metabolism by copper (“cuproptosis”) can induce multiple cuproptosis-related genes. Hepatocellular carcinoma (HCC) is a poorly prognosed widespread cancer having danger advanced metastasis. Therefore, earlier diagnosis followed the specific targeted therapy are required for improved prognosis. The work herein constructed scoring system built on ten...
LIM and SH3 protein 1 (LASP-1) is demonstrated to play a key role in occurrence development of tumors. However, the expression function LASP-1 cholangiocarcinoma (CCA) remain largely unexplored. This study aimed investigate effect regulated on migration, invasion, proliferation, apoptosis CCA cells tumorigenesis vivo, examine clinico-oncological correlates expression. Expression by immunohistochemistry was evaluated tissue samples. HCCC-9810 RBE were transfected with small interfering RNA...
Objective: To analyze the clinicopathological features and gene mutations of primary gastrointestinal stromal tumors (GISTs) stomach intestine prognosis intermediate- high-risk GISTs. Methods: This was a retrospective cohort study. Data patients with GISTs admitted to Tianjin Medical University Cancer Institute Hospital from January 2011 December 2019 were collected retrospectively. Patients gastric or intestinal disease who had undergone endoscopic surgical resection lesion confirmed...
Cancer-associated fibroblasts (CAFs) are an important component of the tumor microenvironment (TME). CAFs can promote occurrence and metastasis by promoting cancer cell proliferation, angiogenesis, extracellular matrix (ECM) remodeling, drug resistance. Nevertheless, how related to Lung adenocarcinoma (LUAD) has not yet been revealed, especially since CAFs-related prediction model be established. We combined Single-cell RNA-sequencing (scRNA-seq) Bulk-RNA data develop a predictive 8...
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and DNA polymerase delta (POLD) family significantly related to cancer prognosis. This study aimed explore significance POLD in HCC via damage repair (DDR) pathway.Data mining was conducted using bioinformatics methods. RNA sequencing clinicopathological data were collected from The Cancer Genome Atlas, GTEx database Gumz Renal cohort. Statistical analyses also performed samples (n>12,000) Affiliated Hospital...
MAGUK p55 subfamily member 7, a part of the membrane palmitoylated protein subfamily, is an essential adapter that promotes epithelial cell polarity and has increasing significance in multiple cancers, including esophageal cancer, clear renal carcinoma, breast pancreatic ductal adenocarcinoma. This paper aims to determine effect 7 various tumor types using The Cancer Genome Atlas Genotype-Tissue Expression database. A variety software web platforms, such as cBioPortal, GEPIA2, TIMER2,...
Accurate treatment response assessment using serial CT scans is essential in oncological clinical trials. However, oncologists' following the Response Evaluation Criteria Solid Tumors (RECIST) guideline subjective, time-consuming, and sometimes fallible. Advanced liver cancer often presents multifocal hepatic lesions on imaging, making accurate characterization more challenging than with other malignancies. In this work, we developed a tumor volume guided comprehensive objective evaluation...
Increasing evidence indicates that DNA polymerase epsilon (POLE), which mediates damage repair, is significantly associated with tumor prognosis. This study aimed to analyze POLE expression in samples and its prognostic value for patients clear cell renal carcinoma (ccRCC). We found elevated ccRCC tissues compared normal of multiple independent cohorts. The levels 523 (The Cancer Genome Atlas RNA-seq data) 179 immunohistochemical data (Fudan University Shanghai Center) were analyzed...
Objective: To analyze the expression of mismatch repair (MMR) protein and EB virus infection in gastric adenocarcinoma, to examine association MMR with clinicopathological parameters. Methods: A case-control study was performed. Clinicopathological data patients who pathologically diagnosed as received radical gastrectomy had complete from August 2017 April 2020 Tianjin Medical University Cancer Institute Hospital were retrospectively collected analyzed. The immunohistochemistry (IHC)...
Objective To evaluate the effect of Budesonide combined with Poractant Alfa(pulmonary surfactants, PS) on preventing bronchopulmonary dysplasia(BPD) in preterm infants. Methods One hundred and twenty infants 6 hours after birth(gestational ages≤32 weeks birth weights≤1 500 g)admitted to Department Newborn Medicine, Affiliated Hospital Southeast Medical University from October 2013 February 2015 were randomly divided into 4 group(30 cases each group). Group A was a control group, group...