A5100753512- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Multiple and Secondary Primary Cancers
- Epigenetics and DNA Methylation
- Genital Health and Disease
- Cancer, Lipids, and Metabolism
- Nanoplatforms for cancer theranostics
- Urinary and Genital Oncology Studies
- Pediatric Urology and Nephrology Studies
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Tuberous Sclerosis Complex Research
- Prostate Cancer Diagnosis and Treatment
Fudan University Shanghai Cancer Center
2016-2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Shanghai Medical College of Fudan University
2011-2024
Shanghai Cancer Institute
2022-2024
Fudan University
2009-2024
State Key Laboratory of Genetic Engineering
2022
Southern Medical University
2022
China Agricultural University
2022
Sun Yat-sen University
2018-2021
Sun Yat-sen University Cancer Center
2018-2021
Abstract In recent years, the environmental health issue of microplastics has aroused an increasingly significant concern. Some studies suggested that exposure to polystyrene (PS-MPs) may lead renal inflammation and oxidative stress in animals. However, little is known about essential effects PS-MPs with high-fat diet (HFD) on development microenvironment. this study, we provided single-cell transcriptomic landscape kidney microenvironment induced by HFD mouse models unbiased RNA sequencing...
Abstract Tertiary lymphoid structures (TLS) are organized aggregates of immune cells that form under pathological conditions. However, the predictive value TLS in clear cell renal carcinoma (ccRCC) for immunotherapies remains unclear. We comprehensively assessed implications prognosis and immunological responses spatial maturation heterogeneity 655 ccRCC patients. A higher proportion early‐TLS was found peritumoral TLS, while intratumoral mainly comprised secondary follicle‐like (SFL‐TLS),...
Abstract Background Super-enhancers (SEs) play a crucial role in cancer, which is often associate with activated oncogenes. However, little known about how SEs facilitate tumour suppression. Individuals Down syndrome exhibit remarkably reduced incidence of breast cancer (BC), moving the search for tumor suppressor genes on human chromosome 21 (HSA21). In this study, we aim to identify and explore potential mechanisms by are established RCAN1.4 HSA21 BC. Methods silico analysis...
Abstract Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare type of kidney cancer, which not well characterized. Here we show the comprehensive proteogenomic analysis tRCC tumors and normal adjacent tissues to elucidate molecular landscape this disease. Our study reveals that defective DNA repair plays an important role in carcinogenesis progression. Metabolic processes are markedly dysregulated at both mRNA protein levels. Proteomic...
<title>Abstract</title> Gemcitabine resistance is a critical factor contributing to the recurrence and progression of bladder cancer. In this study, we utilized high-throughput drug screening cancer organoid models identify Bavachalcone (Bava) as sensitizing agent for gemcitabine, thereby inhibiting Bava targets transferrin receptor (TFRC) epidermal growth (EGFR), competitively binding TFRC with (Tf), which reduces influx iron ions activity mitochondrial respiratory chain complexes....
Abstract Background Radical cystectomy (RC) is the standard treatment for patients with muscle-invasive bladder cancer (BC), and it also a valid option selected high-risk non-muscle-invasive BC. The purpose of this study was to evaluate effect on lower skeletal muscle index (SMI) short-term postoperative complications radical in (BC). Methods A total 247 who received RC BC 204 age-matched healthy population-based controls were retrospectively assessed. SMI measured by preoperative computed...
Abstract Clear cell renal carcinoma (ccRCC) is the most common subtype of kidney cancer characterized by metabolic reprogramming. Glutamine metabolism pivotal in reprogramming, contributing to significant heterogeneity observed ccRCC. Consequently, developing prognostic markers associated with glutamine could enhance personalized treatment strategies for ccRCC patients. This study obtained RNA sequencing and clinical data from 763 cases sourced multiple databases. Consensus clustering 74...
// Fangning Wan 1, 2, * , Hongkai Wang Yijun Shen 2 Hailiang Zhang Guohai Shi Yao Zhu Bo Dai Dingwei Ye 1 Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic China Oncology, Medical College, University, These authors have contributed equally to this work Correspondence to: Ye, e-mail: dwyeli@163.com Keywords: COL6A1, clear cell renal carcinoma, prognosis, tumorigenesis Received: May 08, 2015 Accepted: July 27, Published: August 07, ABSTRACT Background...
Abstract The tyrosine kinase inhibitor (TKI) Sunitinib is one the therapies approved for advanced renal cell carcinoma. Here, we undertake proteogenomic profiling of 115 tumors from patients with clear carcinoma (ccRCC) undergoing treatment and reveal molecular basis differential clinical outcomes TKI therapy. We find that chromosome 7q gain-induced mTOR signaling activation associated poor therapeutic treatment, whereas aristolochic acid signature VHL mutation synergistically caused...
Upper tract urothelial carcinoma (UTUC) is often diagnosed late and exhibits poor prognosis. Limited data are available on potential non-invasive biomarkers for disease monitoring. Here, we investigate the proteomic profile of plasma in 362 UTUC patients 239 healthy controls. We present an integrated tissue-plasma approach to infer signature proteins identifying with muscle-invasive UTUC. discover a protein panel that reflects lymph node metastasis, which interest high risk also identify...
Aldosterone, which plays a key role in maintaining water and electrolyte balance, is produced by zona glomerulosa cells of the adrenal cortex. Autonomous overproduction aldosterone from causes primary hyperaldosteronism. Recent clinical studies have highlighted pathological KCNJ5 potassium channel Our objective was to determine whether small-conductance Ca(2+)-activated (SK) channels may also regulate secretion human adrenocortical cells. We found that apamin, prototypic inhibitor SK...
Abstract The purpose of the present study was to investigate whether genetic variants that influence angiogenesis and sorafenib pharmacokinetics are associated with clinical outcomes toxic effects in advanced renal cell carcinoma patients treated this drug. One hundred were enrolled. Forty-two polymorphisms 15 genes selected for genotyping analyzed associations progression-free survival, overall survival effects. We found rs1570360 VEGF rs2239702 VEGFR2 significantly progression-free....
Sex-determining region Y‑box protein (SOX) genes serve an important role in cancer growth and metastasis. The present study aimed to determine the predictive ability of SOX associated identified through molecular network clear cell renal carcinoma (RCC). A total 505 patients with RCC from Cancer Genome Atlas (TCGA) cohorts were collected this study. expression profile obtained TCGA RNAseq database. Clinicopathological characteristics, including age, gender, tumor grade, stage, laterality...
Malignant ureteral obstruction (MUO) is an unpropitious sign that commonly observed in patients with advanced incurable cancer. The present study aimed to evaluate predictive factors for the failure of retrograde stent insertion management MUO outpatients. A total 164 were retrospectively assessed this study. Clinical factors, including age, gender, type malignancy, level obstruction, cause pre-operative creatinine level, degree hydronephrosis, condition contralateral ureter, prior...
Clear cell renal carcinoma (ccRCC) is a malignancy with heterogeneous outcomes. Currently, mass biopsies are commonly employed to extract disease characteristics and aid prognosis. Although the pathological diagnosis of malignant accurate in contemporary reports, classification Fuhrman grade using biopsy specimens remains far from promising. To generate gene signature distinguish high-grade ccRCC, we used cancer genome atlas (TCGA) database develop expression for distinguishing (G3/4)...
Recent studies have indicated that low circulating adiponectin concentrations are associated with a higher risk of several cancers, including renal cell carcinoma. In this case-control study, we examined the frequency single nucleotide polymorphisms (rs182052G>A, rs266729C>G, and rs3774262G>A) in gene (ADIPOQ) 1004 patients clear carcinoma (ccRCC) compared group healthy subjects (n = 1108). Fasting serum were also examined. Logistic regression models used to estimate odds ratios (OR) 95%...
Programmed death ligand-1 (PD-L1), a promising antitumor target, has proven clinical value against many malignancies. However, the PD-L1 content of Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) and its correlation with outcomes remain unclear. This study aimed to investigate expression in RCC assess prognostic value. Formalin-fixed paraffin-embedded specimens from 36 adult patients that were histologically confirmed (by fluorescence situ hybridization) subjected immunohistochemical...
Aldosterone, which plays a key role in the regulation of blood pressure, is produced by zona glomerulosa (ZG) cells adrenal cortex. Exaggerated overproduction aldosterone from ZG causes primary hyperaldosteronism. In cells, calcium entry through voltage-gated channels central secretion. Previous studies animal adrenals and human adrenocortical cell lines suggest that T-type but not L-type channel activity drives production. However, recent clinical show somatic mutations are second most...