A5100457980- Renal cell carcinoma treatment
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Renal and Vascular Pathologies
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Urological Disorders and Treatments
- Cancer-related gene regulation
- Urinary Bladder and Prostate Research
- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Ureteral procedures and complications
- Pelvic floor disorders treatments
- MRI in cancer diagnosis
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Treatment and Research
- Peroxisome Proliferator-Activated Receptors
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2025
Soochow University
2025
Second Affiliated Hospital of Soochow University
2025
Shanghai Jiao Tong University
2024
Jiangsu Province Hospital
2015-2024
West China Hospital of Sichuan University
2024
Nanjing Medical University
2015-2024
Ruijin Hospital
2024
Sichuan University
2024
Fifth Tianjin Central Hospital
2023
We aimed to study the role of METTL3 in renal cell carcinoma (RCC) carcinogenesis and development. Immunohistochemistry was performed clinical tissue microarray. Expression level RCC tissues lines evaluated by quantitative real-time PCR (qRT-PCR) western blot. Then, effects on proliferation, migration, invasion cycle were studied cells. Additionally, vivo carried out nude mice. Negative expression associated with larger tumor size (P=0.010) higher histological grade (P=0.021). Moreover,...
Background The mTOR signaling pathway plays a crucial role in the carcinogenesis of renal cell cancer (RCC). We sought to investigate influence genetic variations pathway-related genes on risk RCC. Methods genotyped 8 potentially functional polymorphisms AKT1, AKT2, PTEN and MTOR using TaqMan method case-control study 710 RCC patients 760 cancer-free subjects. Unconditional logistic regression, adjusted for potential confounding factors, was used assess associations. then examined...
The hypoxia-inducible factor-1α (HIF-1α) plays an important role in regulating angiogenesis, which is essential for tumor growth and metastasis. Genetic variations of HIF1A (coding HIF-1α) have been shown to influence individual's susceptibility many human tumors; however, evidence on associations between single-nucleotide polymorphisms (SNPs) prostate cancer (PCa) risk conflicting. We genotyped three potentially functional (rs11549465, rs11549467 rs2057482) using the TaqMan method assessed...
Antisense long noncoding RNAs (lncRNAs) are reported to play a regulating role in carcinogenesis of various human malignancies. However, the function lncRNAs and their underlying mechanism renal cell carcinoma (RCC) is still unknown. The aims this study investigate expression lncRNA BX357664 RCC explore its lines. As result, was downregulated according previous microarray analysis qualitative real-time polymerase chain reaction. After upregulation BX357664, reduced migration, invasion,...
Lactate dehydrogenase C is an isoenzyme of lactate and a member the cancer–testis antigens family. In this study, we aimed to investigate expression functional role its basic mechanisms in renal cell carcinoma. First, total 133 cases carcinoma samples were analysed tissue microarray, Kaplan–Meier survival curve analyses performed correlation between progression. protein levels messenger RNA significantly upregulated tissues, patients with positive had shorter progression-free survival,...
Abstract Background Ubiquitylation modification is one of the multiple post-transcriptional process to regulate cellular physiology, including cell signaling, cycle regulation, DNA repair and transcriptional regulation. Members TRIM family proteins could be defined as E3 ubiquitin ligases they contain a RING-finger domain, alterations are involved into broad range diverse disorders cancer. TRIM37 novel discovered ligase acts oncoprotein in human neoplasms, however its biological role RCC...
Abstract Background Triple-negative breast cancer (TNBC) represents a highly aggressive subset of malignancies characterized by its challenging clinical management and unfavorable prognosis. While TFAP2A, member the AP-2 transcription factor family, has been implicated in maintaining basal phenotype cancer, precise regulatory role TNBC remains undefined. Methods In vitro assessments cell growth migratory potential were conducted using MTS, colony formation, EdU assays. Quantitative PCR was...
Human oxoguanine glycosylase 1 (hOGG1) is a DNA repair enzyme, which plays important roles in the base excision (BER) pathway. Several studies reported common polymorphism Ser326Cys (rs1052133) hOGG1, conferred susceptibility of bladder cancer. We hypothesized that associated with risk cancer Chinese population. In case-control study 1050 histologically confirmed patients and 1404 age sex matched healthy controls, we genotyped hOGG1 using TaqMan technology assessed its association risk....
Genetic variations in a PTEN/AKT/mTOR signaling axis may influence cellular functions including cell growth, proliferation and apoptosis, then increase the individual's risk of cancer. Accordingly, we explore association between single nucleotide polymorphisms (SNPs) these genes prostate cancer (PCa) our Chinese population.Subjects were recruited from 666 PCa patients 708 cancer-free controls, eight SNPs determined by TaqMan assay. Odds ratios (OR) 95% confidence intervals (95% CI) evaluated...
Background Recent large-scale transcriptome analyses have found large numbers of transcripts, including that long non-coding RNAs (lncRNAs), which are aberrant in various diseases, especially cancers. However, it is not clear whether lncRNAs involved specifically renal cell carcinoma (RCC). We investigated the expression patterns five RCC tumor samples (T) relative to those matched adjacent non-tumor tissues (N) via microarray. Methods A microarray with 33,045 lncRNA probes and 30,215 mRNA...
Abstract The purpose of the present study was to investigate whether genetic variants that influence angiogenesis and sorafenib pharmacokinetics are associated with clinical outcomes toxic effects in advanced renal cell carcinoma patients treated this drug. One hundred were enrolled. Forty-two polymorphisms 15 genes selected for genotyping analyzed associations progression-free survival, overall survival effects. We found rs1570360 VEGF rs2239702 VEGFR2 significantly progression-free....
Background Survivin is an inhibitor of apoptosis protein and involved in the occurrence progression human malignancies. Recently, a functional polymorphism (−31G>C, rs9904341) promoter survivin has been shown to influence its expression confer susceptibility different types cancer. The present study was aimed investigate whether also influences renal cell cancer (RCC) Chinese population. Methods We genotyped this using TaqMan assay case-control comprised 710 RCC patients 760 controls....
Background. Recent research found that N5-methylcytosine (m5C) was involved in the development and occurrence of numerous cancers. However, function mechanism m5C RNA methylation regulators clear cell renal carcinoma (ccRCC) remains undiscovered. This study is aimed at investigating predictive clinical value these m5C-related genes ccRCC. Methods. Based on The Cancer Genome Atlas (TCGA) database, expression patterns twelve matched clinicopathological characteristics were downloaded analyzed....
Dysregulation of SMAD4 (i.e. somatic mutation) is strongly associated with poor pancreatic ductal adenocarcinoma (PDAC) prognosis, yet the molecular mechanisms remain underlying this relationship obscure. Previously, we discovered that mutation renders cancer resistant to radiotherapy via promotion autophagy. In current work, observed a downregulation protein level in PDAC as compared adjacent normal tissue, and such
Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) is a DNA repair protein, which plays important roles in the base excision (BER) pathway. Genetic variations of APE1 have been shown to influence an individual's susceptibility carcinogenesis. We hypothesized genetic polymorphisms are associated with risk renal cell carcinoma (RCC). In case‐control study 612 RCC patients and 632 age sex matched healthy controls, we genotyped two functional (−656 T>G, rs1760944 1349 rs1130409) assessed...
The calpain 2 (CAPN2) is upregulated in various malignant carcinomas. Previous studies have reported that CAPN2 functioned as an oncogenic factor human cancers. However, its clinical role and potential effects on cell metastasis proliferation renal carcinoma (RCC) remain unknown. In this study, we evaluated the mRNA protein levels of RCC specimens, matched normal lines using quantitative Real-time PCR (RT-PCR) western blot. Immunohistochemistry 74 tissues a tissue microarrays (TMAs) kidney...
The mRNA expression of CAPN2 was upregulated in CRPC cells (DU145 and PC3) than that non-CRPC cells. Silencing could inhibit DU145 PC3 proliferation by cell cycle arrest at G1 phase. Knockdown CPAN2 level suppressed the migration invasion capacity reducing matrix metalloproteinase-2 (MMP-2) MMP-9 activation, as well repressing phosphorylation protein AKT mTOR. In addition, we found elevated Pca tissues normal control tissues. Therefore, showed important roles development progression cells,...
// Jundong Zhu 1, * , Chao Liang Yibo Hua Chenkui Miao 1 Jianzhong Zhang Aiming Xu Kai Zhao Shouyong Liu Ye Tian Huiyu Dong Pu Li Shifeng Su Qin and Zengjun Wang Department of Urology, The First Affiliated Hospital Nanjing Medical University, Nanjing, China These authors contributed equally to this work Correspondence to: Wang, email: zengjunwang@njmu.edu.cn Qin, 13776678978@163.com Keywords: CD82/KAI1, tetraspanin, migration/invasion, TGF-β1/Smad signaling, renal cell carcinoma Received:...