A5103259513- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Biomarkers in Disease Mechanisms
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Renal and related cancers
- Reproductive System and Pregnancy
- Acute Kidney Injury Research
- Cleft Lip and Palate Research
- Protease and Inhibitor Mechanisms
- Kruppel-like factors research
- Testicular diseases and treatments
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
Nanjing Medical University
2012-2023
Institute of Forensic Science
2023
Zhejiang Sci-Tech University
2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2021
Nanjing Maternity and Child Health Care Hospital
2020
Jiangsu Province Hospital
2016-2019
University of Arkansas for Medical Sciences
2019
Nanjing Jiangning Hospital
2019
Qingdao University
2017-2018
Qingdao Municipal Hospital
2018
We aimed to study the role of METTL3 in renal cell carcinoma (RCC) carcinogenesis and development. Immunohistochemistry was performed clinical tissue microarray. Expression level RCC tissues lines evaluated by quantitative real-time PCR (qRT-PCR) western blot. Then, effects on proliferation, migration, invasion cycle were studied cells. Additionally, vivo carried out nude mice. Negative expression associated with larger tumor size (P=0.010) higher histological grade (P=0.021). Moreover,...
Acute kidney injury (AKI) induced by ischemia‐reperfusion is a critical conundrum in many clinical settings. Here, this study aimed to determine whether and how RTA‐408, novel oleanane triterpenoid, could confer protection against renal (IRI) male mice. Mice treated with RTA‐408 undergoing unilateral ischemia followed contralateral nephrectomy had improved function histological outcome, as well decreased apoptosis, ROS production, oxidative marker compared vehicle‐treated Also, we found that...
Background/Aims: MicroRNAs regulate a wide range of biological processes non-small cell lung cancer (NSCLC). Although miR-598 has been reported to act as suppressor in osteosarcoma and colorectal cancer, the physiological function NSCLC remains unknown. In this study, role was investigated. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) conducted estimate expression Derlin-1 (DERL1) both tissues lines. Immunohistochemistry (IHC) analyzed association between...
Changzhou has been confronted with great challenges in birth defects (BDs) prevention, as the prevalence rates of BDs increased rapidly. The aims this study were to describe epidemiology perinatal infants (PIs, including dead fetus, stillbirth, or live between 28 weeks gestation and 7 days after birth) during period from 2014 2018.The BD surveillance data PIs collected 56 hospitals Changzhou. rate 95% confidence interval (CI) calculated by Poisson distribution. Univariate multivariate...
Abstract It is widely accepted that inflammation an important risk for the development of prostate cancer (PCa). The objective this study was designed to investigate potential molecular mechanism NLR family, pyrin domain-containing protein 3 (NLRP3) inflammasome in malignant progression PCa. expression level NLRP3 evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) and fluorescence situ hybridization. effects PCa applying gain- loss-of-function assays LNCaP PC3 cell lines...
Epithelial-mesenchymal transition (EMT) has an important function in cancer. Recently, microRNAs have been reported to be involved EMT by regulating target genes. miR-942 is considered a novel oncogene esophageal squamous cell carcinoma. However, its role non-small-cell lung cancer (NSCLC) not investigated. In this study, the expression of NSCLC patients tumor and paired adjacent tissues were assessed quantitative real-time polymerase chain reaction situ hybridization. Transwell, wound...
As a population-based national surveillance region, Tianning District confronts with great challenges in birth defects (BDs) prevention. We aimed to describe the epidemiology of BDs infants (including dead fetus, stillbirth, or live between 28 weeks gestation and 42 days after birth) from 2014 2018. The data was collected defect system. prevalence rates were calculated by poisson distribution. Trends incidence associations regarding perinatal characteristics analyzed regression. During study...
Abstract Long non‐coding RNAs (lncRNAs) take various biological effects in clear cell renal carcinoma (ccRCC) mostly through sponging with microRNAs (miRNAs). lncRNA MIR4435‐2HG is found to promote tumour progression gastric cancer, glioblastoma and hepatocellular carcinoma. However, the role of ccRCC remains unknown. The purpose this research was investigate potential molecular mechanism regarding regulation initiation progression. In study, we up‐regulation tissues lines. Functionally,...
Genetic variants may influence miRNA–mRNA interaction through modulate binding affinity, creating or destroying miRNA-binding sites. Twenty-four single nucleotide polymorphisms (SNPs) that were predicted to affect the affinity of breast cancer-related miRNAs 3′-untranslated regions (UTR) known genes genotyped in 878 cancer cases and 900 controls Chinese women. Three promising SNPs (rs10494836, rs10857748 rs7963551) further validated additional 914 967 controls. The variant allele (C)...
Di-n-butyl phthalate (DBP) is a kind of ubiquitous chemical linked to hormonal disruptions that affects male reproductive system. However, the mechanism DBP-induced germ cells toxicity remains unclear. Here, we demonstrate DBP induces reduction proliferation, increase apoptosis and DNA damage dependent on PTEN/AKT pathway. Mechanistically, decreases PTEN promoter methylation increases its transcriptional activity, leading increased expression. Notably, DNMT3b confirmed as target miR-29b...
Di-N-butylphthalate (DBP) have given rise to more and attention due its unique endocrine toxicity male reproductive system. Our previous studies demonstrated antioxidative Nrf2 (nuclear factor erythroid related 2) pathway play a vital role in DBP induced oxidative stress injury. ANXA5 (annexin A5), which is highly expressed testicular Leydig Sertoli cells, was found upregulated after stimulation. Mouse cells were exposed different concentration of for 24 h examine the ROS (Reactive oxygen...
di-N-butylphthalate (DBP) is a ubiquitous environmental pollutant used for plastic coating and in the cosmetics industry. It has toxic effects on body health, especially male reproductive system. Here, we investigated of DBP system pubertal mice explored protective role sulforaphane (SFN). The results showed that significantly reduced anogenital distance, testicular weight, sperm count motility, plasma testosterone levels increased oxidative stress, abnormalities, cell apoptosis. SFN...
Annexin A5 has been found to act as an oncogenic protein in a variety of cancers. However, its specific biological role and mechanism renal cell cancer (RCC) remains unknown. Quantitative Real-time PCR western blotting were used evaluate the mRNA expression level human RCC lines tissues. Immunohistochemistry was adopted measure 123 cases Survival analysis performed explore association between prognosis RCC. The effect on growth metastasis studied vitro vivo. frequently highly expressed both...
The advent of high-throughput sequencing methods has facilitated identification novel long non-coding RNAs (lncRNAs), which have been demonstrated to play an important role in multiple tumors. Moreover, with the assistance bioinformatics analysis, LINC01605 found be up-regulated bladder cancer (BC) tissues compared normal tissues. Hence, present study was explore its specific biological and related mechanism BC. relative expression level measured a cohort BC matched as well human cell lines...
The present study was performed to determine the protective effect of Zinc on rat testicular ischemia-reperfusion (I/R) injury and its mechanism.
Di-N-butylphthalate (DBP) is one of the most common endocrine-disrupting chemicals which can disrupt human endocrine system, especially in male reproductive system. Here, this study was aimed to determine whether sulforaphane (SFN) could protect against testicular oxidative stress injury induced by DBP mice offsprings. Wild-type (Nrf2+/+) and Nrf2-deficient (Nrf2-/-) timed-pregnant were given orally from embryonic day (E)14.5 E19.5. Subsequently, markers evaluated. Besides, Nrf2, NF-κB,...