Lei Zhang

ORCID: 0000-0003-3973-6886
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About
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Research Areas
  • Quantum Dots Synthesis And Properties
  • Ginseng Biological Effects and Applications
  • Chalcogenide Semiconductor Thin Films
  • Drug-Induced Hepatotoxicity and Protection
  • Health, psychology, and well-being
  • Nutrition, Genetics, and Disease
  • Biochemical effects in animals
  • Liver Disease Diagnosis and Treatment
  • Phytochemical and Pharmacological Studies
  • Educational Technology and Assessment
  • Cardiac Health and Mental Health
  • Educational Technology and Pedagogy
  • Pharmacological Effects of Natural Compounds
  • Saffron Plant Research Studies
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Plant Gene Expression Analysis
  • Plant-derived Lignans Synthesis and Bioactivity
  • Sulfur Compounds in Biology
  • Animal testing and alternatives
  • 14-3-3 protein interactions
  • Fatty Acid Research and Health
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Liver physiology and pathology
  • Pathogenesis and Treatment of Hiccups
  • Fuel Cells and Related Materials

First Affiliated Hospital of Henan University of Science and Technology
2025

Mudanjiang Normal University
2016-2024

First Hospital of Lanzhou University
2019-2024

Lanzhou University
2019-2024

Hanjiang Normal University
2017-2021

Zhengzhou University
2020

Jiangsu Province Hospital
2019

Melbourne Sexual Health Centre
2019

Alfred Health
2019

Nanjing Medical University
2019

In this work, we found, that exogenous melatonin pretreatment improved anthocyanin accumulation (1- to 2-fold) in cabbage. To verify the relationship with and anthocyanin, an Arabidopsis mutant, snat, which expresses a defective form of biosynthesis enzyme SNAT (Serotonin N-acetyl transferase), was employed. Under cold conditions, foliage wild-type exhibited deeper red color than snat mutant. This finding further proved, treatment able affect accumulation. gain better understanding how...

10.3389/fpls.2016.00197 article EN cc-by Frontiers in Plant Science 2016-03-23

Patients with chronic obstructive pulmonary disease (COPD) often experience depression and anxiety, but little information is available regarding Chinese patients these conditions. The present study assessed anxiety in COPD. A case–controlled was designed 1100 COPD enrolled the case group and1100 residents without respiratory symptoms selected as control group. Anxiety both groups were evaluated using Hospital Depression Scale (HADS). body mass index,degree of airflow obstruction, dyspnea,...

10.1186/1471-2466-12-53 article EN cc-by BMC Pulmonary Medicine 2012-09-09

Glucagon-like peptide (GLP)-1 is a potent glucose-dependent insulinotropic gut hormone released from intestinal L cells. The aim of this study was to investigate isoquercitrin as an inhibitor dipeptidyl peptidase IV (DPP-IV) and determine whether it affects GLP-1 release in normal mice NCI-H716 In vitro, we used chromogenic substrate method detection methods measure DPP-IV. We found that competitive inhibitor, with IC50 Ki values 96.8 236 μM, respectively. Isoquercitrin sitagliptin also...

10.1039/c8ra00675j article EN cc-by RSC Advances 2018-01-01

Di-N-butylphthalate (DBP) have given rise to more and attention due its unique endocrine toxicity male reproductive system. Our previous studies demonstrated antioxidative Nrf2 (nuclear factor erythroid related 2) pathway play a vital role in DBP induced oxidative stress injury. ANXA5 (annexin A5), which is highly expressed testicular Leydig Sertoli cells, was found upregulated after stimulation. Mouse cells were exposed different concentration of for 24 h examine the ROS (Reactive oxygen...

10.1016/j.etap.2019.103236 article EN cc-by-nc-nd Environmental Toxicology and Pharmacology 2019-08-01

This study was designed to evaluate the protective effects of Arctium lappa L. root extracts (AREs) from different extraction methods (aqueous, ethanol, chloroform and flavone) on atherosclerosis. Quails (Coturnix coturnix) were subjected high fat diet, with or without one four AREs positive control simvastatin. Blood samples collected before treatment, after 4.5 weeks ten assess lipid profile (Levels total cholesterol (TC), Triacylglycerol (TG), low-density lipoprotein (LDL) high-density...

10.1186/s12906-016-0987-2 article EN cc-by BMC Complementary and Alternative Medicine 2015-12-01

Abstract Objectives It was found that total flavonoids from Litsea coreana Levl. (TFLC), which is a traditional Chinese medicine, had preventive effect against hepatic steatosis in our previous study. This study designed to evaluate whether TFLC could improve liver fibrosis rats. Methods The model rats were treated with composite factors of high-fat emulsion (10 ml/kg) via gavage accompanied by subcutaneous injection low-dose CCl4. Thirty given plus (100, 200, 400 mg/kg), respectively, for 8...

10.1211/jpp.62.02.0010 article EN Journal of Pharmacy and Pharmacology 2010-02-01

Background: Depressive and anxiety symptoms increase the risk of death in patients with Chronic Obstructive Pulmonary Disease (COPD), but combined effects two factors are unknown. Purpose: To assess possible interactive depressive on COPD. Methods: Prospective data for 7787 Chinese COPD was analyzed deaths were recorded. evaluated using Hospital Anxiety Depression Scale. A product added to logistic regression model evaluate multiplicative interaction, relative excess interaction (RERI),...

10.3109/15412555.2013.822856 article EN COPD Journal of Chronic Obstructive Pulmonary Disease 2014-07-10

We successfully extracted isoliquiritigenin from Glycyrrhiza uralensis through the utilization of an ionic liquid-based ultrasonic-assisted extraction (ILUAE) approach. Briefly, we utilized solution 1-butyl-3-methylimidazolium bromide ([BMIM]Br) as solvent and optimized key ILUAE parameters such solid-liquid ratios, concentrations liquids, times ultrasonication. Based on a single-factor experiment, response surface method (RSM) approach to optimize procedure. The revealed that optimal energy...

10.1155/2020/7102046 article EN cc-by BioMed Research International 2020-10-01

(Abstracted from Genet Med 2019;21:1958–1968) It is generally accepted that genetic screening has the potential to prevent disease through early identification. The authors suggest one cost-effective way implement into a single-payer or state-funded health care system combined approach—one tests for multiple conditions concurrently—versus individual targeted testing.

10.1097/01.ogx.0000654116.18244.8f article EN Obstetrical & Gynecological Survey 2020-02-01

Quercetin was extracted from Portulaca oleracea L. through biphasic acid hydrolysis to investigate its potential as a suppressor of dipeptidyl peptidase IV (DPP-IV) and hypoglycemic effect in type 2 diabetic mice. The extraction procedure optimized utilizing the response surface method (RSM) single-factor experimental setting. An efficiency 0.675% achieved using following parameters: 0.064 mol/L vitriol, 1 : 109.155 solid-liquid ratio, 21.408 min ultrasonication. Overall, findings indicate...

10.1155/2023/8886503 article EN cc-by Evidence-based Complementary and Alternative Medicine 2023-01-01

We successfully extracted isoliquiritigenin from Glycyrrhiza uralensis via fermentation with Aspergillus niger and ultrasonic‐assisted extraction. In brief, we used A. to culture G. powder, optimized some key parameters such as reaction conditions of pH, inoculation concentration , time, solid‐liquid ratio. Based on a single‐factor experiment, utilized the response surface methodology (RSM) approach optimize this extraction procedure. Using RSM approach, pH = 3.694, ratio 1 : 2.155, 1466745...

10.1155/2020/8927858 article EN cc-by Evidence-based Complementary and Alternative Medicine 2020-01-01

Increased psychiatric comorbidity, predominantly anxiety and depressive symptoms, lower quality of life (QoL) are associated with noncardiac chest pain (NCCP). We aimed to investigate the roles depression in impaired QoL NCCP patients Central China. In this hospital-based cross-sectional study, 200 consecutive who complained normal coronary angiography were enrolled Department Cardiology Gastroenterology, Union Hospital, Wuhan, Meanwhile, 100 healthy controls, age sex-matched, recruited....

10.1097/md.0000000000005289 article EN cc-by-nc Medicine 2016-11-01

To analyze the prognostic factors in patients with acute hypertensive intracerebral hemorrhage (HICH) undergoing minimally invasive puncture and drainage, providing scientific evidence to enhance clinical treatment strategies. A retrospective analysis was conducted on 350 HICH treated at Gansu Provincial Hospital of Traditional Chinese Medicine First People's Lanzhou City from March 2017 January 2024. Patients were divided into two groups based surgical method: control group (n = 211)...

10.62347/pqpp5715 article EN American Journal of Translational Research 2024-01-01

In this study, we investigated the effect and mechanism of Resibufogenin on renal cell carcinoma based network pharmacology, molecular docking, in vitro experiments. The results showed that there were 35 cross-targets between carcinoma. GO KEGG pathway analyses indicated inhibited cancer cells through vascular smooth muscle contraction signalling EGFR tyrosine kinase inhibitor resistance signaling pathway, MAPK1, PRKCB, had strong associative activities. After different concentrations...

10.3390/biology13121064 article EN cc-by Biology 2024-12-19

It is well-known that long-term participation in sports beneficial for physical fitness, especially older adults. However, little known about potential differences fitness effects with different common sports. PURPOSE: This study investigated the of four popular (Aerobics, Tai-chi, Diabolo, and Track Field) middle-aged females. METHODS: One hundred fifteen female subjects (aged 45-54 years old), who were selected to be National Sports Instructors (NSI) China (2016 2017), participated this...

10.1249/01.mss.0000682676.45744.d9 article EN Medicine & Science in Sports & Exercise 2020-07-01
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