A5051049599- Gastroesophageal reflux and treatments
- Pelvic floor disorders treatments
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Pancreatitis Pathology and Treatment
- Anorectal Disease Treatments and Outcomes
- Esophageal and GI Pathology
- Congenital gastrointestinal and neural anomalies
- Ferroptosis and cancer prognosis
- Gastrointestinal disorders and treatments
- Healthcare professionals’ stress and burnout
- Pancreatic and Hepatic Oncology Research
- Dysphagia Assessment and Management
- Urinary Bladder and Prostate Research
- COVID-19 and Mental Health
- Cancer-related molecular mechanisms research
- Eosinophilic Disorders and Syndromes
- Sleep and Wakefulness Research
- Peripheral Nerve Disorders
- Restless Legs Syndrome Research
- Diverticular Disease and Complications
Tongde Hospital of Zhejiang Province
2024-2025
Zhejiang Chinese Medical University
2025
First Affiliated Hospital of GuangXi Medical University
2015-2024
Guangxi Medical University
2015-2024
Huazhong University of Science and Technology
2013-2024
Union Hospital
2013-2024
Union Hospital
2020-2022
Wuhan Union Hospital
2020-2022
Augusta University
2017-2021
Zhongkai University of Agriculture and Engineering
2021
Acute pancreatitis (AP) is a pathological condition characterized by the premature release and activation of trypsinogens other enzyme precursors. In severe cases, mortality rates are in range 20–30% may even be as high 50%. Though various prophylaxes available for AP, mechanism its progression unclear. Marginal zone B B-1 cell-specific protein 1 (MZB1) found endoplasmic reticulum (ER) where it expressed exclusively cells there. MZB1 promotes proliferation, inhibits apoptosis, invasion,...
Background: The potential functions of Thrombospondin 2 (THBS2) in the progression and immune infiltration gastric cancer (GC) remain unclear. purpose this study was to clarify role THBS2 GC prognosis relationship between cell infiltration. Material Methods: differential expression levels cancer-adjacent tissues were identified using TCGA databases verified real-time polymerase chain reaction (PCR), immunohistochemical staining two datasets from Gene Expression Omnibus (GEO). related...
Abstract Ferroptosis is closely associated with inflammatory diseases, including acute pancreatitis (AP); however, the involvement of ferroptosis in hypertriglyceridemic (HTGP) remains unclear. In present study, we aimed to explore relationship between lipid metabolism and HTGP alleviating effect liproxstatin-1 (Lip-1) vivo. This study represents first exploration endoplasmic reticulum stress (ERS) HTGP, targeting as a key factor HTGP. Hypertriglyceridemia (HTG) was induced under high-fat...
Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a benign, vasculogenic lesion with unclear etiology. Despite increased recognition its imaging features, rates misinterpretation and unnecessary surgery for SANT remain high, possible association benign malignant tumors have been suggested. This study aimed to systematically analyze clinical characteristics improve clinician radiologist knowledge, reduce overtreatment, increase awareness potential concomitant diseases in...
Patients with irritable bowel syndrome (IBS) show pain hypersensitivity and smooth muscle hypercontractility in response to colorectal distension (CRD). Synaptic plasticity, a key process of memory formation, the enteric nervous system may be novel explanation. This study aimed explore regulatory role ephrinB2/ephB2 synaptic plasticity colonic hyperreactive motility IBS. Postinfectious (PI)-IBS was induced by Trichinella spiralis infection rats. Isometric contractions circular strips,...
INTRODUCTION: Treatments for fecal incontinence (FI) remain unsatisfactory because they do not remedy the underlying multifactorial dysfunction(s) including anorectal neuropathy. The aim of this study was to investigate optimal dose frequency, clinical effects, and safety a novel treatment, translumbosacral neuromodulation therapy (TNT), aimed at improving METHODS: Patients with FI were randomized receive 6 sessions weekly TNT treatments consisting 600 repetitive magnetic stimulations over...
Past studies have shown that catheter diameter is one of the device-dependent problems which influence manometric results in conventional water perfusion esophageal manometry. High-resolution solid-state manometry abandons thought as an improved method benefited from more pressure sensors, and it gradually widely used many present motility studies. There was no research to evaluate on high-resolution results. The aim this study investigate whether catheters different provide data Nine...
Most recent studies using high-resolution manometry were based on supine liquid swallows. This study was to evaluate the differences in esophageal motility for and solid swallows upright positions, determine percentages of abnormalities different states.Twenty-four asymptomatic volunteers 26 patients with gastroesophageal reflux disease underwent a 36-channel catheter. The peristalses 10 water steamed bread recorded both positions. Integrated relaxation pressure, contractile front velocity,...
Summary Background Linaclotide, a guanylate cyclase C agonist relieves irritable bowel syndrome with predominant constipation (IBS‐C) symptoms, but how it improves pain in humans is unknown. Aims To investigate the effects of linaclotide and placebo on afferent efferent gut‐brain‐gut signalling IBS‐C patients, randomised clinical trial. Methods Patients (Rome III) rectal hypersensitivity were (2:1) to receive (290 µg) or for 10 weeks undergo bi‐directional gut brain axis assessment using...
Background: Biglycan (BGN) plays a role in the occurrence and progression of several malignant tumors, though its gastric cancer (GC) remains unclear. The objective this study was to investigate BGN expression, GC prognosis, immune infiltration. Material Methods: Gene expression data corresponding clinical information were downloaded from TCGA GTEx, respectively. We compared normal tissues verified differential via Real-Time PCR immunohistochemistry. BGN-related differentially expressed...
AIMTo investigate the effects of depression and anxiety on health-related quality life (QoL) in gastroesophageal reflux disease (GERD) patients those suffering from cardiac (CCP) noncardiac (NCCP) chest pain Wuhan, China. METHODSIn this cross-sectional study, a total 358 consecutive with GERD were enrolled China, which 176 subjects had complaints pain.Those underwent coronary angiography divided into CCP group (52 cases) NCCP (124 cases).Validated questionnaires completed, 36-item Short-Form...
The mitochondrial calcium uniporter (MCU) is a major protein for the uptake of to regulate intracellular energy metabolism, including processes such as mitophagy. present study investigated effect MCU on mitophagy in pancreatic ductal epithelial cells (PDECs) acute pancreatitis (AP) <em>in vitro</em>. normal human PDECs (HPDE6‑C7) were treated with caerulein (CAE) induce AP‑like changes, or without ruthenium red inhibit MCU. membrane potentials (MMPs) and Ca<sup>2+</sup> levels analyzed by...
Intrahepatic cholangiocarcinoma (ICC) is a highly invasive malignant tumor. The prognosis of patients with ICC after radical surgical resection remains poor, due to local infiltration, distant metastasis, high recurrence rate and lack effective treatment strategies. E26 transformation‑specific sequence variant 4 (ETV4) pro‑carcinogenic factor that upregulated in several tumors; however, the role ETV4 relatively unknown. present study aimed determine Hccc9810 cell line assess how it...
Abstract Background Biofeedback therapy is useful for treatment of fecal incontinence (FI), but not widely available and labor intensive. We investigated if home biofeedback (HBT) non‐inferior to office (OBT). Methods Patients with FI (≥1 episode/week) were randomized HBT or OBT 6 weeks. was performed daily using novel device that provided resistance training electrical stimulation voice‐guided instructions. consisted six weekly sessions. Both methods involved anal strength, endurance,...
The current treatment methods available for advanced gastric cancer are not very promising. Hence, it is important to explore novel biomarkers and potential therapeutic agents treat (GC). This study aimed identify hub genes associated with GC prognosis drugs its treatment.Three gene expression data of normal tissues were downloaded from the Gene Expression Omnibus (GEO) processed differentially expressed (DEGs). We conducted a comprehensive analysis DEGs, including functional enrichment...
Circular RNAs (circRNAs) have been found to be involved in the progression of acute pancreatitis (AP). The objective our study was investigate effects circ_0000284 on caerulein-induced AR42J cell injury. To mimic AP vitro, rat pancreatic acinar cells were treated with caerulein. expression and miR-10a-5p evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Enzyme-linked immunosorbent assay (ELISA) employed determine content inflammatory cytokines interleukin (IL)-1β,...