A5115591728- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- High Entropy Alloys Studies
- High-Temperature Coating Behaviors
- Gastric Cancer Management and Outcomes
- Single-cell and spatial transcriptomics
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Organic Light-Emitting Diodes Research
- Radiopharmaceutical Chemistry and Applications
- Organic Electronics and Photovoltaics
- Esophageal Cancer Research and Treatment
- Total Knee Arthroplasty Outcomes
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Knee injuries and reconstruction techniques
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Additive Manufacturing Materials and Processes
Tianjin Medical University
2023-2025
Tianjin Medical University Eye Hospital
2024-2025
Harbin Medical University
2013-2025
Sun Yat-sen University
2016-2025
Shandong University
2019-2025
Yantaishan Hospital
2024-2025
Jiangxi Agricultural University
2024-2025
Tongji University
2025
Tongji Hospital
2015-2025
Nanjing University of Posts and Telecommunications
2021-2025
Organic ultralong room temperature phosphorescence (OURTP) materials having stimuli-responsive attributes have attracted great attention due to their potential in a wide variety of advanced applications. It is fundamental importance but challengeable develop OURTP materials, especially such with modulated optoelectronic properties controlled manner probably the lack an authentic construction approach. Here, we propose effective strategy for controllably regulated by engineering resonance...
A major challenge in understanding vertebrate embryogenesis is the lack of topographical transcriptomic information that can help correlate microenvironmental cues within hierarchy cell-fate decisions. Here, we employed Stereo-seq to profile 91 zebrafish embryo sections covering six critical time points during first 24 h development, obtaining a total 152,977 spots at resolution 10 × 15 μm3 (close cellular size) with spatial coordinates. Meanwhile, identified modules and co-varying genes for...
Pancreatic ductal adenocarcinoma (PDAC) driven by the KRAS-G12D mutation presents a formidable health challenge because of limited treatment options. MRTX1133 is highly selective and first-in-class inhibitor under clinical development. Here, we report that advanced glycosylation end product-specific receptor (AGER) plays key role in mediating resistance PDAC cells. The up-regulation AGER within cancer cells instigates macropinocytosis, facilitating internalization serum albumin subsequent...
Objectives Patients with gallbladder carcinoma (GBC) lack effective treatment methods largely due to the inadequacy of both molecular characterisation and potential therapeutic targets. We previously uncovered a spectrum genomic alterations identified recurrent mutations in ErbB pathway GBC. Here, we aimed study genes pathways larger cohort patients GBC investigate mechanisms clinical significance these mutations. Design performed whole-exome sequencing (WES) 157 Functional experiments were...
A lack of joint specimens with the same natural surface morphology has limited detailed experimental study shearing performances joints. In this technical note, we propose a way to batch-produce rock joints surfaces by three-dimensional (3D) optical scanning original gain their digitally geometry and then 3D rigid engraving. We also present method for characterizing shear damage joint. Manufacturing practice sandstone, marble, granite demonstrates its advantages in reliable precision high...
Effective interventions to improve prognosis in metastatic esophagogastric cancer (EGC) are urgently needed. We assessed the effect of early integration interdisciplinary supportive care for patients with EGC on overall survival (OS).
Abstract Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms controlling protein feeding remain poorly understood. Here we report that in Drosophila , intake-induced inhibition (PIFI) specific to protein-containing food, this effect mediated by a fat body (FB) peptide named female-specific independent transformer (FIT). Upon consumption FIT expression greatly elevated. Secreted fly haemolymph conveys metabolic message brain, thereby promoting release...
Abstract Since its first emergence in 2004, the high‐entropy alloy (HEA) concept has aimed at stabilizing single‐ or dual‐phase multi‐element solid solutions through high mixing entropy. Here, this strategy is changed and renders such massive metastable, to trigger spinodal decomposition for improving alloys’ magnetic properties. The motivation starting from a HEA approach provide chemical degrees of freedom required tailor behavior using multiple components. key idea form Fe‐Co enriched...
Magnetic Nanoparticles In article number 2302686, Jiurong Liu, Zhihui Zeng, and co-workers report a type of N-doped carbon nanotube encapsulated CoNi alloy nanocomposites with diverse heterostructures, which deliver excellent electromagnetic wave absorption performance involving minimum reflection loss −84.0 dB at the thickness 3.2 mm maximum effective bandwidth 4.3 GHz.
The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum (ER) presents an opportunity to amplify synergistic effects chemotherapy and immunotherapy. In this study, we initially validated celastrol (CEL) as inducer immunogenic cell death (ICD) by promoting ER stress autophagy in colorectal cancer (CRC) cells. Subsequently, ER-targeted strategy was posited, involving codelivery CEL with PD-L1 small interfering RNAs (siRNA) using KDEL peptide-modified exosomes...