A5019559491- Ultrasound Imaging and Elastography
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Nonmelanoma Skin Cancer Studies
- Cryospheric studies and observations
- Fluid Dynamics and Vibration Analysis
- Photosynthetic Processes and Mechanisms
- Hydrocarbon exploration and reservoir analysis
- Ultrasonics and Acoustic Wave Propagation
- Glycosylation and Glycoproteins Research
- Thyroid Cancer Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Cutaneous Melanoma Detection and Management
- Hydrology and Watershed Management Studies
- Cancer and Skin Lesions
- Breast Lesions and Carcinomas
- Lattice Boltzmann Simulation Studies
- Autophagy in Disease and Therapy
- Plant biochemistry and biosynthesis
- Orthopaedic implants and arthroplasty
- Metallurgy and Material Forming
- Aerosol Filtration and Electrostatic Precipitation
- AI in cancer detection
- Bone Tissue Engineering Materials
Guangdong Pharmaceutical University
2023-2025
Shanghai Tenth People's Hospital
2016-2025
Tongji University
2016-2025
Institute of Tibetan Plateau Research
2021-2025
Shanghai Normal University
2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
University of Electronic Science and Technology of China
2025
Shanghai Skin Disease Hospital
2022-2024
University of Shanghai for Science and Technology
2024
Hangzhou Children's Hospital
2024
Abstract Combined checkpoint blockade (e.g., PD1/PD-L1) with traditional clinical therapies can be hampered by side effects and low tumour-therapeutic outcome, hindering broad translation. Here we report a combined modality based on integrating nanosonosensitizers-augmented noninvasive sonodynamic therapy (SDT) checkpoint-blockade immunotherapy. All components of the nanosonosensitizers (HMME/R837@Lip) are clinically approved, wherein liposomes act as carriers to co-encapsulate...
Abstract Despite the efficacy of current starvation therapies, they are often associated with some intrinsic drawbacks such as poor persistence, facile tumor metastasis and recurrence. Herein, we establish an extravascular gelation shrinkage-derived internal stress strategy for squeezing narrowing blood vessels, occluding & nutrition supply, reducing vascular density, inducing hypoxia apoptosis eventually realizing therapy malignancies. To this end, a biocompatible composite hydrogel...
Abstract EVA1A (also known as transmembrane protein 166) is a involved in the regulation of autophagy that acts an adaptor to recruit or bind proteins lysosome endoplasmic reticulum. In present study, we identified target microRNA-125b (miR-125b), member highly conserved family miRNAs has been proposed biomarker for hepatocellular carcinoma (HCC). Analysis oxaliplatin-sensitive and oxaliplatin-resistant HCC cell lines showed miR-125b downregulated resistant cells its overexpression sensitive...
Accurately simulating glacier mass balance (GMB) data is crucial for assessing the impacts of climate change on dynamics. Since physical models often face challenges in comprehensively accounting factors influencing glacial melt and uncertainties inputs, machine learning (ML) offers a viable alternative due to its robust flexibility nonlinear fitting capability. However, effectiveness ML modeling GMB across diverse types within High Mountain Asia has not yet been thoroughly explored. This...
Studies have shown the potential of nanomaterials for accurate and early detection cancer. The aim present study was to design evaluate value prostate-specific membrane antigen (PSA)-targeted manganese oxide–mesoporous silica nanoparticles (Mn–Msns) prostate Mn–Msns were prepared, then conjugated with PSA antibody Cy7 create multimodality PSA-Mn-Msn-Cy7. Their particle size, zeta potential, stability magnetic resonance imaging (MRI) features characterized. Optical MR evaluated in cell...
As a minimally invasive heat source, radiofrequency (RF) ablation still encounters potential damages to the surrounding normal tissues because of diffusion, high power, and long time. With comprehensive understanding current state art on RF ablation, magnetic composite using porous hollow iron oxide nanoparticles (HIONs) as carriers load dl-menthol (DLM) has been engineered. This involves two protocols for enhancing that is, HION-mediated magnetothermal conversion in field solidoid...
Wind energy is one of the most cost-effective sources available today. Some techniques have been developed to scavenge wind energy, but making use lower flutter velocity while maintaining high conversion efficiency remains challenging. Here, we report a triboelectric nanogenerator composed two interacting films with four flapping modes, enabling an effective work as low 1.6 ms−1 and 3.23%, which, our knowledge, are better than previously reported values scavenging. The output performance...
Due to the scarcity of observational data and intricate precipitation–runoff relationship, individually applying physically based hydrological models machine learning (ML) techniques presents challenges in accurately predicting floods within data-scarce glacial river basins. To address this challenge, study introduces an innovative hybrid model that synergistically harnesses strengths multi-source remote sensing data, a (i.e., Spatial Processes Hydrology (SPHY)), ML techniques. This novel...
BackgroundClinical appearance and high-frequency ultrasound (HFUS) are indispensable for diagnosing skin diseases by providing internal external information. However, their complex combination brings challenges primary care physicians dermatologists. Thus, we developed a deep multimodal fusion network (DMFN) model combining analysis of clinical close-up HFUS images binary multiclass classification in diseases.MethodsBetween Jan 10, 2017, Dec 31, 2020, the DMFN was trained validated using...
Biomarkers (e.g., acidity, H2O2, hypoxia, and specific molecules) as one primary component of tumor microenvironments are closely associated with occurrence, invasion, metastasis malignancy, thus can act biological targets. However, their monitoring remains a challenging task. Herein, coordination-dependent longitudinal relaxation tuning (CLRT) that occurs between Mn2+ "donor" "acceptor" is established to enable target sensing. Relying on the differences coordination ability spatial...
Abstract Objective This study investigated the correlation of liver fat content (LFC) with metabolic characteristics and its association chronic complications in type 2 diabetes mellitus (T2DM) patients. Methods Eighty-one prospectively enrolled T2DM patients were divided into non-alcoholic fatty disease (NAFLD) group non-NAFLD according to presence NAFL complications. LFC was determined by MRI IDEAL-IQ Sequence, 4 groups quartile method. Basic information, indexes, occurrence different...