A5102025225- Vitamin K Research Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Enzyme Catalysis and Immobilization
- Enzyme Production and Characterization
- Vitamin C and Antioxidants Research
- Microbial Metabolic Engineering and Bioproduction
- Crystallography and molecular interactions
- Microbial Fuel Cells and Bioremediation
- Air Quality and Health Impacts
- Steroid Chemistry and Biochemistry
- Pharmacological Effects of Natural Compounds
- Microbial Natural Products and Biosynthesis
- Essential Oils and Antimicrobial Activity
- Protein Kinase Regulation and GTPase Signaling
- Tannin, Tannase and Anticancer Activities
- Heavy Metal Exposure and Toxicity
- Fungal Biology and Applications
- Air Quality Monitoring and Forecasting
- Identification and Quantification in Food
- Calcium Carbonate Crystallization and Inhibition
- Microbial Applications in Construction Materials
- Medicinal Plants and Neuroprotection
- Aluminum toxicity and tolerance in plants and animals
- Environmental Quality and Pollution
Anhui Polytechnic University
2012-2024
Stanford University
2024
Anhui Institute of Robotics Industrial Technology Research Institute
2023
Sichuan Agricultural University
2022
Heilongjiang Provincial Academy of Agricultural Sciences
2021
Dalian University
2020
Key Laboratory of Guangdong Province
2019
Chinese Academy of Fishery Sciences
2019
Ministry of Agriculture and Rural Affairs
2019
Virginia Commonwealth University
2017
Chronic exposure to cadmium (Cd) via food and drinking water is a major human health concern. We have previously shown that metallothionein (MT), metal-binding protein, plays an important role in protecting against Cd toxicity produced by repeated sc injections. However, it unclear whether MT protects Cd-induced nephrotoxicity following chronic oral exposure, route with obvious relevance. To clarify this issue, MT-I/II knockout (MT-null) background-matched wild-type (WT) mice were allowed...
Abstract Background Members of the WRKY protein family, one largest transcription factor families in plants, are involved plant growth and development, signal transduction, senescence, stress resistance. However, little information is available about factors flax ( Linum usitatissimum L.). Results In this study, comprehensive genome-wide characterization gene family was conducted that led to prediction 102 LuWRKY genes. Based on bioinformatics-based predictions structural phylogenetic...
As a natural biological macromolecule, γ-polyglutamic acid (γ-PGA) plays significant role in medicine, food, and cosmetic industries owing to its unique properties of biocompatibility, biodegradability, water solubility, viscosity. Although many strategies have been adopted increase the yield γ-PGA Bacillus subtilis, effectiveness these common approaches is not high because strong viscosity affects cell growth. However, dynamic regulation based on quorum sensing (QS) has extensively applied...
Abstract Streptococcus sanguinis is an early colonizer of the tooth surface and competes with oral pathogens such as mutans to maintain health. However, little known about its mechanism biofilm formation. Here, we show that mutation ciaR gene, encoding response regulator CiaRH two-component system in S . SK36, produced a fragile biofilm. Cell aggregation, gtfP gene expression water-insoluble glucan production were all reduced, which suggested polysaccharide was decreased Δ RNA sequencing...
Menaquinone (MK-7) is a highly valuable vitamin K2 produced by Bacillus subtilis. Common static metabolic engineering approaches for promoting the production of MK-7 have been studied previously. However, these caused an accumulation toxic substances and reduced product yield. Hence, dynamic regulation quorum sensing (QS) system promising method achieving balance between synthesis cell growth.In this study, QS transcriptional regulator SinR, which plays significant role in biofilm formation...
Indigoidine, as a kind of natural blue pigment, is widely used in textiles, food, and pharmaceuticals mainly synthesized from l-glutamine via condensation reaction by indigoidine synthetases, most which originates Streptomyces species. However, due to the complex metabolic switches Streptomyces, researchers choose overexpress synthetases heterologous host achieve high-level production indigoidine. Considering advantages low-cost culture medium simple conditions during large-scale here, an...
The pathophysiological mechanisms of heart failure (HF) stems were mainly from longstanding overactivation the sympathetic nervous system and renin-angiotensin-aldosterone system. Recent studies highlighted potential benefits β1-adrenoceptor (β1-AR) blocker combined with β2-adrenergic receptor (β2-AR) agonist in patients HF. Long-term exposure to fine particulate air pollution, such as matter ≤ 2.5 μm diameter (PM2.5), has been found associated acute myocardial infarction (AMI) which is most...
Eudragit L100-55-halloysite nanotubes (EL100-55, HNTs) nanocomposite microcapsules were introduced to release nattokinase (NK) and avoid the limitations of oral systemic administration NK while increasing entrapment efficiency stability NK. The drug loading capacity, stability, shapes (NK@HNTs-EL) characterized with Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission (TEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA). maximum rate...
Piperine is an important active component of the Chinese herb Large leaf moss. The aim this study was to investigate effects piperine on oxidative stress. An stress model developed in rabbit atrial cells treated with low concentrations hydrogen peroxide (H2O2). A primary cell culture established and were randomly divided into three groups: group, H2O2 group a control group. results demonstrated that viability superoxide dismutase activity significantly higher than (P<0.05), expression levels...
The complete mitogenome sequence of the milk shark, which Rhizoprionodon acutus was determined using long PCR. genome 16,693 bp in length and it contained 13 protein-coding genes, 2 ribosomal RNA 22 transfer 1 D-loop region. overall base composition heavy strand is A (31.63%), C (23.91%), T (31.38%), G (13.08%). However, (13.08%), (23.91%) light strand. Except for that COXI began with GTG, all protein initiation codons were ATG. What’s more, termination TAA, addition to ND2, ND3, Cytb ended...
ABSTRACT Assembly-line polyketide synthases are large multienzyme systems with considerable potential for genetic reprogramming. To investigate the mechanisms by which reactive biosynthetic intermediates directionally channeled across a defined sequence of active sites in naturally occurring assembly line, we employed bifunctional reagent to crosslink transient domain-domain interfaces 6-deoxyerythronolide B synthase. Structural resolution these crosslinked states single-particle cryogenic...