A5006243652- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Effects and risks of endocrine disrupting chemicals
- Renal and related cancers
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Research Studies
- Bladder and Urothelial Cancer Treatments
- Circular RNAs in diseases
- Cancer-related gene regulation
- Genital Health and Disease
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- Testicular diseases and treatments
- Cancer Cells and Metastasis
- Crystallization and Solubility Studies
- Colorectal Cancer Screening and Detection
- Proteoglycans and glycosaminoglycans research
- Advancements in Transdermal Drug Delivery
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Caveolin-1 and cellular processes
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2015-2025
Jiangsu Cancer Hospital
2024-2025
Guangzhou University of Chinese Medicine
2024
Suzhou Municipal Hospital
2024
Southeast University
2024
Zhejiang University
2020
Shanghai Municipal Center For Disease Control Prevention
2015
Bladder cancer (BLCA) is a common malignant tumor of the urinary tract, which sixth most among men. Numerous studies suggested that pyroptosis and long noncoding RNAs (lncRNAs) played an essential role in development cancers. However, pyroptosis-related lncRNAs BLCA their prognostic value are still unclear.In this study, we constructed signature model through least absolute shrinkage selection operator (LASSO) Cox regression analysis univariate based on The Cancer Genome Atlas (TCGA)...
Background: Clear cell renal carcinoma (ccRCC) is a prevalent and aggressive subtype of kidney cancer, often associated with metastasis recurrence. Identifying key genes involved in ccRCC progression critical for improving treatment strategies patient outcomes. Methods: We performed large-scale genome-wide CRISPR screening to identify crucial using the DepMap database. For discovery validation, we integrated multi-omics data from The Cancer Genome Atlas (TCGA), GEO, NJMU-ccRCC clinical...
Background Colorectal cancer (CRC) is a major cause of morbidity and mortality. In previous epidemiologic studies, the respective correlation between lifestyle factors comorbidity CRC has been extensively studied. However, little known about their joint effects on CRC. Methods We conducted retrospective case-control study 1,144 diagnosed patients 60,549 community controls. A structured questionnaire was administered to participants socio-demographic factors, anthropometric measures, history...
Abstract Background Studies over the past decade have shown that competitive endogenous RNA (ceRNA) plays an essential role in tumorigenesis and progression of clear cell renal carcinoma (ccRCC). Meanwhile, immune checkpoint blocker is gradually moving towards first-line treatment ccRCC. Hence, it’s urgent to develop a new prediction model for efficiency immunotherapy. At present, there no study reveal effect ceRNA network on immunotherapy Methods To systematically analyze hub genes ccRCCon...
Background. Recent research found that N5-methylcytosine (m5C) was involved in the development and occurrence of numerous cancers. However, function mechanism m5C RNA methylation regulators clear cell renal carcinoma (ccRCC) remains undiscovered. This study is aimed at investigating predictive clinical value these m5C-related genes ccRCC. Methods. Based on The Cancer Genome Atlas (TCGA) database, expression patterns twelve matched clinicopathological characteristics were downloaded analyzed....
Abstract Cigarette smoking was known to accelerate the occurrence and development of bladder cancer by regulating RNA modification. However, association between combination cigarette modification‐related single nucleotide polymorphisms (RNAm‐SNPs) risk remains unclear. In this study, 1681 participants, including 580 cases 1101 controls, were recruited for genetic analysis. total, 1 287 990 RNAm‐SNPs involving nine modifications (m 6 A, m Am, 2'‐O‐Me, 5 C, 7 G, A‐to‐I, U, pseudouridine...
Seminoma is the most common subtype of testicular germ cell tumor, with an increasing incidence worldwide. Clusterin (CLU) expression was found to be downregulated in seminoma our previous study. We now expanded sample size, and further indicated that CLU correlates tumor stage. Tcam-2 line used investigate function seminoma, inhibit proliferation metastasis abilities. Besides, extracellular matrix protein COL15a1 demonstrated as downstream affect epithelial-mesenchymal transition (EMT)...
Background Renal clear cell carcinoma (ccRCC) is one of the most prevalent cancers worldwide. Accumulating evidence revealed that copper-induced death played a vital role in various tumors. However, underlying mechanism cuproptosis with molecular heterogeneity and tumor microenvironment (TME) ccRCC remains to be elucidated. The present study aimed discover biological function regulators potential guide clinical therapy. Methods Using Single-cell RNA-seq, bulk transcriptome other multi-omics...
Abstract Glycolysis-related metabolic reprogramming is a central hallmark of human cancers, especially in renal cell carcinoma. However, the regulatory function glycolytic signature papillary RCC has not been well elucidated. In present study, glycolysis-immune predictive was constructed and validated using WGCNA, clustering analysis. PPI network DEGs visualized. Functional enrichments patients’ overall survival were analyzed. QRT-PCR experiments performed to detect hub genes’ expression...
Cigarette smoking causes multiple cancers by directly influencing mutation burden of driver mutations. However, the mechanism between somatic caused cigarette and bladder tumorigenesis remains elusive. Smoking-related profile cancer was characterized The Cancer Genome Atlas cohort. Integraticve OncoGenomics database utilized to detect smoking-related genes, its biological predictions were interpreted based on bulk transcriptome single-cell transcriptome, as well cell experiments. associated...
Abstract Background Renal clear cell carcinoma (ccRCC) is the most prevalent tumors worldwide. Discovering effective biomarkers essential to monitor prognosis and provide alternative clinical options. SPTBN1 implicated in various cancerous processes. However, its role ccRCC remains unelucidated. This study intends explore biological function mechanism of ccRCC. Methods Single-cell bulk RNA-seq, tissue microarray, real-time quantitative PCR, western blotting were applied verify expression...
m6A RNA modification is a common abundant posttranscriptional of mRNAs occurring in cancer growth and progression. Accumulated evidence has proved that HNRNPC, which acts as reader, plays an essential role the promotion occurrence development; nevertheless, HNRNPC papillary renal cell carcinoma remained to be discovered. In this study, we comprehensively identified hub gene involved pRCC. Then, expression level, survival outcomes, PPI network, function enrichment, immune infiltration,...
Seminal vesiculitis is a prevalent infectious disease in the genitourinary system, but its intrinsic pathogenesis and molecular features remain unclear. In this study, we utilized next-generation sequencing technology to demonstrate transcriptomic landscapes of clinical specimens from seminal patients. We identified enriched Go Ontology terms, pathway maps, processes, toxicity, metabolic networks vesiculitis. Glutathione S-transferase activity highly enriched, indicating essential role...
Abstract Background: Cow’s milk is a highly-nutritious dairy product that widely consumed worldwide. It secreted by the developed mammary gland (MG) of cattle. However, comprehensive understanding cell-type diversity and cell function within bovine MG lacking. In current study, we used single-cell RNA sequencing to investigate transcriptome 24,472 high-quality cells isolated from newborn adult cows. Results: Unbiased clustering analysis revealed existence 24 types, which could be divided...