A5071529729- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Chromatin Remodeling and Cancer
- Protein Degradation and Inhibitors
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Glutathione Transferases and Polymorphisms
- Air Quality and Health Impacts
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Antioxidant Activity and Oxidative Stress
- Data-Driven Disease Surveillance
- Retinoids in leukemia and cellular processes
- Climate Change and Health Impacts
- COVID-19 epidemiological studies
- Nutrition, Genetics, and Disease
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2024
Hong Kong University of Science and Technology
2022
University of Hong Kong
2022
Jiangsu Cancer Hospital
2022
BioMimetic Systems (United States)
2022
Biosensores (Spain)
2022
Nanjing University
2018-2021
Genomics (United Kingdom)
2018-2021
Harvard University
2021
The association between vitamin E and cancer risk has been widely investigated by observational studies, but the findings remain inconclusive. Here, we aimed to evaluate causal effect of circulating on ten common cancers, including bladder, breast, colorectal, esophagus, lung, oral pharynx, ovarian, pancreatic, prostate, kidney cancer.A Mendelian randomization (MR) analytic framework was applied data from a cancer-specific genome-wide study (GWAS) comprising total 297,699 cases 304,736...
Incidence of early-onset colorectal cancer (EOCRC), defined by a diagnosed age under 50 years, is increasing, but its heterogeneous etiologies that differ from general CRC remain undetermined. We initially characterize the genome, epigenome, transcriptome, and proteome tumors 79 patients in Chinese cohort. Data for an additional 126 EOCRC subjects are obtained International Cancer Genome Consortium cohort The Atlas European observe have high tumor mutation burden; increased DNA repair...
The association between air pollution and childhood respiratory disease is inconsistent. In the present study, we investigated a short-term effect of ambient pollutants daily lower diseases (CLRD). Daily pollutants, weather data, CLRD data were collected from January 2014 to April 2015 (452 days) in Nanjing, China. Time-series regression generalized additive models used assess effects (PM10, PM2.5, NO2, SO2, O3, CO) on CLRD. We observed that an interquartile range (IQR) increase...
The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise polygenic prognostic score (PPS) stratifying overall survival. Leveraging two cohorts 3703 patients, first perform genome-wide association analysis develop eight candidate PPSs. Further using independent cohort with 470 identify the 287 variants-derived PPS (i.e., PPS287) achieving optimal performance [hazard ratio (HR) per SD = 1.99, P 1.76 ×...
Primary colon cancers arising from the left and right sides exhibit distinct clinical molecular characteristics. Sidedness-associated heterogeneity relies intricately on oncogenic properties of cancer cells multicellular interactions in tumor microenvironments. Here, combining transcriptomic profiling 426,863 single 105 patients validation with spatial transcriptomics large-scale histological analysis, we capture common transcriptional patterns between left- right-sided malignant epithelia...
Obesity is correlated with increased colorectal cancer (CRC) risk, but few studies have investigated lifetime body mass index (BMI) metrics and CRC risk. In a cohort of 139 229 subjects in the Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial, we analysed effects life-course BMI trajectories on At 13 years follow-up, 2031 developed CRC. Compared who were never overweight/obese, first exceeded threshold 25 kg m−2 at age 20 had higher risk (HR = 1.28, 95% confidence interval...
Fine particulate matter (PM2.5) is suspected to increase the risk of colorectal cancer, but mechanism remains unknown. We aimed investigate association between PM2.5 exposure, genetic variants and cancer in Prostate, Lung, Colon Ovarian (PLCO) Cancer Screening trial. included a prospective cohort 139,534 cancer-free individuals from 10 United States research centers with over ten years follow-up. used Cox regression model assess exposure incidence by calculating hazard ratio (HR) 95%...
Abstract Genome-wide association studies (GWASs) underlying case-control design have uncovered hundreds of genetic loci involved in tumorigenesis and provided rich resources for identifying risk factors biomarkers associated with cancer susceptibility. However, the application GWAS determining architecture survival remains unestablished. Here, we systematically evaluated effects at genome-wide level on that included overall (OS) cancer-specific (CSS), leveraging data deposited UK Biobank...
Abstract PIWI-interacting RNAs (piRNAs) are an emerging class of non-coding involved in tumorigenesis. Expression quantitative trait locus (eQTL) analysis has been demonstrated to help reveal the genetic mechanism single nucleotide polymorphisms (SNPs) cancer etiology. However, there no databases that have constructed provide eQTL between SNPs and piRNA expression. In this study, we collected genotyping expression data for 10 997 samples across 33 types from The Cancer Genome Atlas (TCGA)....
Abstract Genetic variants in regions encoding 3′ untranslated (UTR) of mRNA potentially alter miRNA binding affinity and N6-methyladenosine (m6A) levels to affect gene expression. A better understanding the association these with colorectal cancer susceptibility could facilitate development prevention treatment approaches. Here, we analyzed expression profiles integrated genetic analyses from 8,533 individuals evaluate effects altered miRNA-binding sites on risk. The single-nucleotide...
The current study aimed to investigate associations of circRNAs and related genetic variants with risk prostate cancer (PCa) as well elucidate biological mechanisms underlying the associations. By using MiOncoCirc database, we first compared expression levels between 25 paired PCa adjacent normal tissues identify risk-associated circRNAs. We then used logistic regression models evaluate in candidate among 4662 patients 3114 healthy controls, identified <italic>circHIBADH</italic> rs11973492...
Genetic and epigenetic alterations occur in many physiological pathological processes. The existing knowledge regarding the association of PIWI-interacting RNAs (piRNAs) their genetic variants on risk progression prostate cancer (PCa) is limited. In this study, three genome-wide study datasets are combined, including 85,707 PCa cases 166,247 controls, to uncover piRNAs. Functional investigations involved manipulating piRNA expression cellular mouse models its oncogenetic role PCa. A specific...
Genome-wide association studies (GWASs) have identified single nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) risk, but whether these SNPs additive effects on the risk of CRC remains unclear. We performed a systematic analysis GWAS-identified using GWAS datasets from China (2,248 patients and 3,173 controls) Europe (4,461 4,140 controls). analyzed 58 independent variants DNA samples Chinese populations found 19 that were significantly risk. two genetic scores (GRSs)...
The integrated analytical strategy identified both genetic and epigenetic biomarkers for gastric cancer etiology.
Environmental pollutants known as polycyclic aromatic hydrocarbons (PAHs) are produced through the incomplete combustion of organic material. While PAHs have been investigated genotoxicants, they can also operate nongenotoxic pathways in estrogen-dependent malignancies, such breast, cervical and ovarian cancer. However, whether induce colorectal cancer (CRC) risk estrogenic effects is still illusive. Here, we systematically abnormal expression activation estrogen receptor beta (ERβ)...