A5020433888- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Glutathione Transferases and Polymorphisms
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Helicobacter pylori-related gastroenterology studies
- Genomics, phytochemicals, and oxidative stress
- Plant biochemistry and biosynthesis
- Air Quality and Health Impacts
- Phytochemicals and Antioxidant Activities
- Bladder and Urothelial Cancer Treatments
- HVDC Systems and Fault Protection
- Plant Gene Expression Analysis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Climate Change and Health Impacts
- Plant Molecular Biology Research
- COVID-19 Clinical Research Studies
- Light effects on plants
- Model-Driven Software Engineering Techniques
- Viral-associated cancers and disorders
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
Nanjing Medical University
2017-2024
Northwest A&F University
2019-2020
Third Xiangya Hospital
2020
Central South University
2020
As a class of natural antioxidants in plants, fruit flavonol metabolites are beneficial to human health. However, the regulatory networks for biosynthesis most fruits largely unknown. Previously, we reported spontaneous pear bud sport 'Red Zaosu' (Pyrus bretschneideri Rehd.) with high flavonoid content its fruit. The identification biosynthetic network this mutant is crucial elucidating mechanism fruit.Here, demonstrated PbMYB12b positively regulated flavonols Initially, investigated...
Aroma affects the sensory quality of fruit and, consequently, consumer satisfaction. Melatonin (MT) is a plant growth regulator used to delay senescence in postharvest during storage; however, its effect on aroma pear remains unclear. In this study, we assessed effects 0.1 mmol L-1 MT volatiles and associated gene expression cultivars 'Korla' (Pyrus brestschneideri Rehd) 'Abbé Fetel' communis L.). mainly affected production C6 aromatic substances two varieties. 'Korla', inhibited PbHPL,...
Abstract Parthenocarpy is a valuable trait in self-incompatible plants, such as pear. N -(2-chloro-4-pyridyl)- N’ -phenylurea (CPPU), synthetic cytokinin analog, can induce parthenocarpy pear ( Pyrus spp.), but the mechanism of induction unclear. To investigate role gibberellin CPPU-induced pear, CPPU supplemented with paclobutrazol (PAC) was sprayed onto ‘Dangshansu’ We found that fruit set rate treated PAC identical to CPPU-alone treatment group. In regard cell development, mainly promoted...
Fine particulate matter (PM2.5) is suspected to increase the risk of colorectal cancer, but mechanism remains unknown. We aimed investigate association between PM2.5 exposure, genetic variants and cancer in Prostate, Lung, Colon Ovarian (PLCO) Cancer Screening trial. included a prospective cohort 139,534 cancer-free individuals from 10 United States research centers with over ten years follow-up. used Cox regression model assess exposure incidence by calculating hazard ratio (HR) 95%...
Inactivation of tumor suppressor genes by promoter hypermethylation plays a key role in the tumorgenesis. It is necessary to uncover detailed pattern whole genome-wide abnormal DNA methylation during development gastric cancer (GC). We performed detection using 12 paired GC tissues and their corresponding normal tissues. Methylation-specific PCR (MSP) bisulphite sequencing (BSP) were used measure status specific CpG site. Based on bioinformatic analysis, cell phenotypes mouse model...
Abstract Emerging evidence has shown that aberrant alternative splicing (AS) events are involved in the carcinogenesis. The association between genetic variants AS and bladder cancer susceptibility remains to be fully elucidated. We searched for single nucleotide polymorphisms (SNPs) which located quantitative trait loci (sQTLs) through CancerSplicingQTL database 1000 Genomes Project. A case‐control study including 580 cases 1,101 controls was conducted assess functional risk. Next, we used...
Background Previous genome-wide association studies (GWASs) have identified that several single nucleotide polymorphisms (SNPs) are implicated in gastric cancer (GC) risk. However, the multiple statistical comparisons of GWASs may reject some true biological positives with subthreshold P values. Methods This study annotated genomic locations all CpG islands genome using Encyclopedia DNA Elements (ENCODE). The SNPs regions were then genotyped Illumina 660W Quad chip. effects prominent...
Anthocyanin biosynthesis exhibits a rhythmic oscillation pattern in some plants. To investigate the correlation between oscillatory regulatory network and anthocyanin pear, accumulation expression patterns of late biosynthetic genes (ALBGs) were investigated fruit skin ‘Red Zaosu’ (Pyrus bretschneideri Rehd.). The accumulated mainly during night over three continuous days skin, ALBGs’ oscillatory. However, levels typical anthocyanin-related transcription factors did not follow this pattern....
Background: The novel coronavirus disease 2019 (COVID-19) is currently breaking out worldwide. COVID-19 patients may have different degrees of coagulopathy, but the mechanism not yet clear. We aimed to analyse relationship between coagulation dysfunction and liver damage in with COVID-19. Methods: A retrospective analysis 74 admitted First People's Hospital Yueyang from 1 January 30 March 2020 was carried out. According function, 27 cases entered coagulopathy group 47 control group. case...
Abstract Background Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori -infected pathogenesis of gastric cancer (GC). A recent study revealed infection induced obviously increased Tff2 methylation levels Muc1 −/− mice compared with controls. However, little is known molecular mechanism on regulating expression . Methods We conducted a correlation analysis public databases our adjacent GC tissues. Besides, overexpression vector or small interfering RNA (siRNA)...
Abstract Cigarette smoke, containing both nicotine and carcinogens, causes lung cancer. However, not all smokers develop cancer, highlighting the importance of interaction between host susceptibility environmental exposure in tumorigenesis. Here, we aimed to delineate metabolizing ability tobacco carcinogens smoking intensity mediating genetic smoking-related Single-variant gene-based associations 43 carcinogen–metabolizing genes with cancer were analyzed using summary statistics...
Although gastric cancer (GC) in young adults (≤ 45 years) accounts for fewer than 10% of newly diagnosed cases, the patients are more likely to have advanced disease at presentation compared with elderly patients. Previous studies identified that DNA methylation genomes different during aging. Our study aimed explore association between and onset GC. We applied Illumina HumanMethylation450 BeadChip examine expression profiles patterns five early GC seven Additionally, we evaluated...
Core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase (C1GALT1) is known to play a critical role in the development of gastric cancer, but few studies have elucidated associations between genetic variants <italic>C1GALT1</italic> and cancer susceptibility. By using GWAS data from database Genotype Phenotype (dbGAP), we evaluated these with logistic regression model identified that rs35999583 was associated risk odd ratio = 0.83, 95% confidence interval 0.75–0.92,...
Aberrant alternative polyadenylation (APA) events play an important role in cancers, but little is known about whether APA-related genetic variants contribute to the susceptibility bladder cancer. Previous genome-wide association study performed APA quantitative trait loci (apaQTL) analyses cancer, and identified 17 955 single nucleotide polymorphisms (SNPs). We found that gene symbols of affected by apaQTL-associated SNPs were closely correlated with cancer signaling pathways, high...
Background: Key genes related to cell cycle and apoptosis pathways play critical roles in bladder cancer. Single nucleotide polymorphisms (SNPs) the 3'-untranslated regions (3'-UTR) of may impact microRNA (miRNA)-messenger RNA (mRNA) binding capacity alter gene expression contribute susceptibility cancers. However, an association genetic variations with cancer risk, has not been reported. Materials Methods: We selected SNPs 3'-UTR genotyped them a case-control study consisting 578 patients...