Mikael Johansson
A5106440813- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Nutritional Studies and Diet
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Glutathione Transferases and Polymorphisms
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Health, Environment, Cognitive Aging
- Angiogenesis and VEGF in Cancer
- BRCA gene mutations in cancer
- Folate and B Vitamins Research
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Disease and Adiposity
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Colorectal Cancer Screening and Detection
- Gallbladder and Bile Duct Disorders
Umeå University
2016-2025
Sir Charles Gairdner Hospital
2019-2024
Queen Elizabeth II Medical Centre
2024
Centre International de Recherche sur le Cancer
2017-2021
Uppsala University
2012
Laboratoire National de Santé
2009-2011
Sahlgrenska University Hospital
2003-2004
University of Gothenburg
1991
Bevacizumab, an antibody against vascular endothelial growth factor (VEGF), is a promising, yet controversial, drug in human glioblastoma treatment (GBM). Its effects on tumor burden, recurrence, and physiology are unclear. We therefore determined the response to bevacizumab at phenotypic, physiological, molecular level clinically relevant intracranial GBM xenograft model derived from patient spheroids. Using anatomical physiological magnetic resonance imaging (MRI), we show that causes...
Abstract DNA hypomethylation in certain genes is associated with tobacco exposure but it unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of from pre-diagnostic blood samples 132 case–control pairs the NOWAC cohort, we observe that most significant associations risk are for cg05575921 AHRR (OR 1 s.d.=0.37, 95% CI: 0.31–0.54, P -value=3.3 × 10 −11 ) and cg03636183 F2RL3 s.d.=0.40, 0.31–0.56, -value=3.9 −10 ), previously shown to...
PURPOSE: To determine the predictive value of vascular endothelial growth factor (VEGF) for relapse-free survival (RFS) and overall (OS) in primary node-positive breast cancer (NPBC) after adjuvant endocrine treatment or chemotherapy. MATERIALS AND METHODS: VEGF was quantitatively measured tumor cytosols from 362 consecutive patients with NPBC using an enzyme immunoassay human 165 . Adjuvant given to all patients, either as therapy (n = 250) chemotherapy 112). The median follow-up time 56...
There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of cases.
DNA methylation changes are associated with cigarette smoking. We used the Illumina Infinium HumanMethylation450 array to determine whether in from pre-diagnostic, peripheral blood samples is lung cancer risk. a case-control study nested within EPIC-Italy cohort and MCCS as discovery sets (a total of 552 pairs). validated top signals 429 pairs another 3 studies. identified six CpGs for which hypomethylation was risk: cg05575921 AHRR gene (p-value
At the time of cancer diagnosis, body mass index (BMI) is inversely correlated with lung risk, which may reflect reverse causality and confounding due to smoking behavior. We used two-sample univariable multivariable Mendelian randomization (MR) estimate causal relationships BMI behaviors on histological subtypes based an aggregated genome-wide association studies (GWASs) analysis in 29 266 cases 56 450 controls. observed a positive effect for high occurrence small-cell (odds ratio (OR) =...
Abstract Identification of risk biomarkers may enhance early detection smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis 731 smoking-matched case-control sets nested within six prospective cohorts from the US, Europe, Singapore, Australia. identify 36 with independently reproducible associations imminent cancer (all p < 4 × 10 −5 ). These include a few markers (e.g. CA-125/MUC-16 CEACAM5/CEA) that have...
We employed stereotactic microdialysis to sample extracellular fluid intracranially from glioblastoma patients, before and during the first five days of conventional radiotherapy treatment. Microdialysis catheters were implanted in contrast enhancing tumor as well brain adjacent (BAT). Reference samples collected subcutaneously patients' abdomen. The analyzed by gas chromatography-time-of-flight mass spectrometry (GC-TOF MS), acquired data was processed hierarchical multivariate curve...
Targeting the kinase ERK5 may disrupt activation of an oncogenic transcription factor in a subset neuroblastoma patients.
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, pathogenic pathways, through which SNPs within affects cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and expression quantitative trait loci (eQTL) on 409 to identify validate underlying pathways investigate combined effect of genes from pathways. The KEGG neuroactive ligand receptor...
Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung etiology via direct measurements pre-diagnostic circulating concentrations a nested case-control study, complemented with Mendelian randomization (MR) approach an independent sample. used biomarker data from 5183 pairs within 20 prospective cohorts, and genetic 29,266 cases 56,450 controls. Exposures included directly measured blood samples 8 single...
To further investigate the role of inflammation in lung carcinogenesis, we evaluated associations between proinflammatory cytokines and cancer risk. We conducted a case-control study nested within 3 prospective cohort studies—the Melbourne Collaborative Cohort Study (1990–1994), Malmö Diet Cancer (1991–1996), Northern Sweden Health Disease (initiated 1985)—involving 807 incident cases smoking-matched controls. Conditional logistic regression models adjusting for serum cotinine concentrations...
Glioma grading and classification, today based on histological features, is not always easy to interpret diagnosis partly relies the personal experience of neuropathologists. The most important feature classification aimed correlation between tumor grade prognosis. However, in clinical reality, large variations exist survival patients concerning both glioblastomas low-grade gliomas. Thus, there a need for biomarkers more reliable glioma tumors as well We analyzed relative metabolite...
Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer Nutrition (EPIC) study. The extent which these associations are present other study populations is unknown.
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal our study has been to integrate complete results with a large‐scale expression quantitative trait loci (eQTL) mapping in human tissues ( n = 1,038) identify candidate causal genes for cancer. performed transcriptome‐wide association (TWAS) overall, by histology (adenocarcinoma, squamous cell carcinoma small cancer) smoking subgroups (never‐ ever‐smokers)....
Recently, a genome-wide association study showed that single nucleotide polymorphism (SNP) -rs11706832-in intron 2 of the human LRIG1 (Leucine-rich repeats and immunoglobulin-like domains 1) gene is associated with susceptibility to glioma. However, mechanism by which rs11706832 affects glioma risk remains unknown; additionally, it unknown whether expression levels are relevant determinant gliomagenesis. Here, we investigated role Lrig1 in platelet-derived growth factor (PDGF)-induced...
Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although basis for these remains elusive. Here, we analyze MHC variation among 26,044 lung patients and 20,836 controls densely genotyped across MHC, using Illumina OncoArray or 660W SNP microarray. We impute sequence in classical HLA genes, fine-map risk with histologies compare results between ethnicities. Independent novel genes are Europeans including amino acids HLA-B*0801 peptide...
Abstract Objectives To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk lung cancer overall, by smoking status (never, former, current smokers), histological sub-type. Design Nested case-control study. Setting 20 population based cohort studies in Asia, Europe, Australia, the United States. Participants 5299 patients with incident cancer, individually incidence density matched controls. Exposure...
Although genome-wide association studies have been conducted to investigate genetic variation of lung tumorigenesis, little is known about gene-gene (G × G) interactions that may influence the risk non-small cell cancer (NSCLC).
Abstract Introduction As the global burden of chronic cancer increases, its correlation to lifestyle, socioeconomic status (SES) and health equity becomes more important. The aim present study was provide a snapshot lifestyle patterns for different types in patients at Nordic tertiary clinic. Materials methods In descriptive observational study, questionnaires addressed highest-attained educational level, occupational economy, relationship status, exposures, habits. questionnaire distributed...