A5009742683- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Endometriosis Research and Treatment
- Glaucoma and retinal disorders
- Endometrial and Cervical Cancer Treatments
- Insect-Plant Interactions and Control
- Epigenetics and DNA Methylation
- Malaria Research and Control
- Ophthalmology and Visual Impairment Studies
- Cardiomyopathy and Myosin Studies
- Phytochemistry and Biological Activities
- Respiratory viral infections research
- Insect Resistance and Genetics
- Reproductive System and Pregnancy
- Bacterial Infections and Vaccines
- Surgical site infection prevention
- Pneumonia and Respiratory Infections
- Genetic diversity and population structure
- Retinal and Optic Conditions
- Coral and Marine Ecosystems Studies
- Spine and Intervertebral Disc Pathology
- Genetics, Bioinformatics, and Biomedical Research
- Cardiovascular Effects of Exercise
The University of Melbourne
2016-2025
Melbourne Bioinformatics
2015-2025
Royal Women's Hospital
2024-2025
University of Maryland, Baltimore
2021-2023
University of Pittsburgh
2023
University of Maryland Center for Environmental Science
2021-2023
University of Vermont
2023
New England College of Optometry
2022
Premier Research Group
2016-2021
Biotechnology Institute
2020
To examine the cross-sectional relationship between blood pressure, perfusion and prevalence of open angle glaucoma (OAG) in an adult Latino population.Participants aged 40 years older (N = 6130) from Los Angeles Eye Study (LALES), a large, population-based study self-identified Latinos, underwent interviewer-administered questionnaire complete ocular clinical examination. Logistic regression was used to evaluate covariate-adjusted association OAG with systolic, diastolic, mean pressures...
Research examining the predictive power of social media (especially Twitter) displays conflicting results, particularly in domain political elections. This paper applies methods used studies that have shown a direct correlation between volume/sentiment Twitter chatter and future electoral results new dataset about We show these display series shortcomings make them inadequate for determining whether messages can predict outcome
Large epidemiological studies evaluating the etiologies, management decisions, and outcomes of adults with meningitis or encephalitis in United States (US) are lacking.Adult patients (≥18 years) by International Classification Diseases, Ninth Revision codes available Premier Healthcare Database during 2011-2014 were analyzed.A total 26429 identified. The median age was 43 years; 53% female. most common etiology enterovirus (13463 [51.6%]), followed unknown (4944 [21.4%]), bacterial (3692...
DNA methylation changes are associated with cigarette smoking. We used the Illumina Infinium HumanMethylation450 array to determine whether in from pre-diagnostic, peripheral blood samples is lung cancer risk. a case-control study nested within EPIC-Italy cohort and MCCS as discovery sets (a total of 552 pairs). validated top signals 429 pairs another 3 studies. identified six CpGs for which hypomethylation was risk: cg05575921 AHRR gene (p-value
In mammalian embryonic gonads, SOX9 is required for the determination of Sertoli cells that orchestrate testis morphogenesis. To identify genetic networks directly regulated by SOX9, we combined analysis SOX9-bound chromatin regions from murine and bovine foetal testes with sequencing RNA samples mouse lacking Sox9. We found controls a conserved programme involves most sex-determining genes. testes, modulates both transcription or indirectly sex-specific differential splicing its target...
Genetic variant effect prediction algorithms are used extensively in clinical genomics and research to determine the likely consequences of amino acid substitutions on protein function. It is vital that we better understand their accuracies limitations because published performance metrics confounded by serious problems circularity error propagation. Here, derive three independent, functionally determined human mutation datasets, UniFun, BRCA1-DMS TP53-TA, employ them, alongside previously...
Large epidemiologic studies evaluating the etiologies, management decisions and outcomes of infants children with meningitis encephalitis in United States are lacking.Children 0-17 years age or as assessed by International Classification Diseases, Ninth Revision, codes available Premier Healthcare Database during 2011-2014 were analyzed.Six thousand six hundred sixty-five patients identified; 3030 (45.5%) younger than 1 year age, 295 (4.4%) 1-2 1460 (21.9%) 3-9 1880 (28.2%) 10-17 age....
The disease- and mortality-related difference between biological age based on DNA methylation chronological (Δage) has been found to have approximately 40% heritability by assuming that the familial correlation is only explained additive genetic factors. We calculated two different Δage measures for 132 middle-aged female twin pairs (66 monozygotic 66 dizygotic pairs) their 215 sisters using data measured Infinium HumanMethylation450 BeadChip arrays. For each measure, combined we estimated...
Biological invasions are increasing globally in number and extent despite efforts to restrict their spread. Knowledge of incursion pathways is necessary prevent new design effective biosecurity protocols at source recipient locations. This study uses genome-wide single nucleotide polymorphisms (SNPs) determine the origin 115 incursive
Nations throughout the Indo-Pacific region use pyrethroid insecticides to control Aedes aegypti, mosquito vector of dengue, often without knowledge resistance status pest or origin resistance. Two mutations (V1016G + F1534C) in sodium channel gene (Vssc) Ae. aegypti modify ion function and cause target-site insecticides, with a third mutation (S989P) having potential additive effect. Of 27 possible genotypes involving these mutations, some allelic combinations are never seen whereas others...
The arbovirus vectors Aedes aegypti (yellow fever mosquito) and Ae. albopictus (Asian tiger are both common throughout the Indo-Pacific region, where 70% of global dengue transmission occurs. For all populations invasive, having spread from an initial native range Africa, while for includes invasive those range: putatively, India to Japan Southeast Asia. This study analyses population genomics 480 these mosquitoes sampled 27 locations in Indo-Pacific. We investigated patterns genome-wide...
Population genomic approaches can characterize dispersal across a single generation through to many generations in the past, bridging gap between individual movement and intergenerational gene flow. These are particularly useful when investigating recently altered systems, where they provide way of inferring long-distance newly established populations their interactions with existing populations. Human-mediated biological invasions represent such systems which be investigated appropriate...
Global DNA methylation has been reported to be associated with urothelial cell carcinoma (UCC) by studies using blood samples collected at diagnosis. Using the Illumina HumanMethylation450 assay, we derived genome-wide measures of and assessed them for their prospective association UCC risk. We used 439 case–control pairs from Melbourne Collaborative Cohort Study matched on age, sex, country birth, sample type, collection period. Conditional logistic regression was compute odds ratios (OR)...
Purpose: Posterior scleral remodeling accompanies myopia. In guinea pigs developing myopia, the region around optic nerve (peripapillary zone, PPZ) rapidly expands followed by inhibition in eye size periphery. We studied differential gene expression sclera that these changes. Methods: Guinea were form-deprived (FD) for 2 weeks to induce while fellow served as a control. After weeks, PPZ and peripheral temporal isolated representative animals extract RNA. RNA sequencing was undertaken using...
To examine whether peripheral blood methylation is associated with risk of developing mature B-cell neoplasms (MBCNs).We conducted a case-control study nested within large prospective cohort. Peripheral was collected from healthy participants. Cases MBCN were identified by linkage to cancer registries. Methylation measured using the Infinium(®) HumanMethylation450.During median 10.6-year follow-up, 438 cases evaluated. Global hypomethylation increased (odds ratio: 2.27, [95% CI: 1.59-3.25])....
BACKGROUND Global measures of peripheral blood DNA methylation have been associated with risk some malignancies, including breast, bladder, and gastric cancer. Here, we examined genome‐wide in prostate cancer its non‐aggressive aggressive disease forms. METHODS We used a matched, case‐control study 687 incident samples, nested within larger prospective cohort study. was measured pre‐diagnostic, samples using the Illumina Infinium HM450K BeadChip. Genome‐wide were computed as median M‐value...
The management of facial nerve palsy following wide local excision and linear closure for malignant melanoma can present a unique set of...
The crustacean molting process is regulated by an interplay of hormones produced the eyestalk ganglia and Y-organs (YO). Molt-inhibiting hormone hyperglycemic released sinus gland (EG) inhibit synthesis secretion ecdysteroid YO, hence regulating hemolymph levels during molt cycle. purpose this study to investigate ecdysteroidogenesis pathway, specifically genes linked changes in occurring at early premolt (ePM). To end, a reference transcriptome based on EG, hepatopancreas was de novo...
A retrospective cohort study design was used to assess the use and costs of diagnostic tests, medication, total hospitalization for pediatric patients with suspected meningitis/encephalitis who received a lumbar puncture (LP) procedure. Related were calculated by timing LP performed infectious etiology infants (<1 year) children (1-17 years). 3030 3635 ME diagnosed between 2011 2014 included in study. The mean cost $12,759 $11,119, respectively, medication laboratory test $834 $1771 $825...
Abstract BACKGROUND Understanding pest incursion pathways is critical for preventing new invasions and stopping the transfer of alleles that reduce efficacy local control methods. The mosquitoes Aedes albopictus (Skuse) Ae. aegypti (Linnaeus) are both highly invasive disease vectors, through a series ongoing international incursions continuing to colonize regions spread insecticide resistance among established populations. This study uses high‐resolution molecular markers set 241 reference...