A5077456973- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Renal cell carcinoma treatment
- Telomeres, Telomerase, and Senescence
- Health, Environment, Cognitive Aging
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Genetic Associations and Epidemiology
- Lung Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Dietary Effects on Health
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- Bladder and Urothelial Cancer Treatments
- Multiple and Secondary Primary Cancers
- Inflammatory Biomarkers in Disease Prognosis
- Plant Pathogens and Resistance
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- Cancer, Lipids, and Metabolism
- Spaceflight effects on biology
- Genetic factors in colorectal cancer
University of Belgrade
2016
Military Medical Academy
2016
Mayo Clinic in Arizona
2016
University of Minnesota
2008-2012
Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although basis for these remains elusive. Here, we analyze MHC variation among 26,044 lung patients and 20,836 controls densely genotyped across MHC, using Illumina OncoArray or 660W SNP microarray. We impute sequence in classical HLA genes, fine-map risk with histologies compare results between ethnicities. Independent novel genes are Europeans including amino acids HLA-B*0801 peptide...
Abstract Background Although early diagnosis and surgical resection of the tumor have been shown to be most important predictors lung cancer survival, long‐term survival for surgically‐resected early‐stage remains poor. Aims In this prospective study we aimed investigate prognostic factors non‐small cell (NSCLC) in Central Eastern Europe. Methods We recruited 2052 patients with stage I‐IIIA NSCLC from 9 centers Russia, Poland, Serbia, Czech Republic, Romania, between 2007–2016 followed them...
Non-small cell lung cancer (NSCLC) represents 80% of all cancers and is the leading cause death worldwide (1). A number factors can affect survival, including patient’s age, NSCLC subtype, tumor genetic characteristics, response to therapy. In addition, stage disease at diagnosis has a profound impact on survival. According American Cancer Society, based analysis SEER registry data between 1998 2000, 5-year survival rates IA IB are 49% 45% respectively, however, decrease around 30% for II...
Promoter hypermethylation of tumor suppressor genes presents promising markers for lung cancer diagnosis and prognosis. The purpose this study was to determine the association between promoter multiple 5-year survival rate in patients with Non-small cell (NSCLC).Primary samples (n = 65), corresponding nonmalignant tissues circulating blood were obtained from NSCLC who underwent curative surgery. methylation status seven (RASSF1A, CDH13, MGMT, ESR1, DAPK, SOX1, HOXA9) quantified by using...
Abstract Background: Colorectal cancers (CRC) have an important impact on both incidence and mortality worldwide, with varying rates in different parts of the world. Despite overall decrease past years, alarming increase early onset colorectal cancer (CRC patients under 50 years age) has been observed. As part Cancer Research UK Grand Challenge Mutographs project, we aim to better understand underlying mutagenic causes contributing differences CRC through mutational signatures. Methods: We...
Improved prediction of prognosis among lung cancer patients could facilitate better clinical management. We aimed to study the prognostic significance circulating proteins at time diagnosis, with and without smoking history.
There are unexplained geographical variations in the incidence of kidney cancer with high rates reported Baltic countries, as well eastern and central Europe. Having access to a large well-annotated collection "tumor/non-tumor" pairs patients from Czech Republic, Romania, Serbia, UK, Russia, we aimed analyze morphology non-neoplastic renal tissue nephrectomy specimens. By applying digital pathology, performed microscopic examination 1012 frozen tissues cell carcinoma. Four components...
Over 140 years ago, the discovery was made that tumor cells morphologically resembling those in primary of a patient can be found patients’ circulation (1). The notion these are probably shed from patient’s confirmed upon advancement cytogenetic techniques demonstrated circulatory also carry genetic abnormalities detected tumors (2).
ABSTRACT Germline genetic variants are involved in lung cancer (LC) susceptibility. Previous genome-wide association studies (GWAS) have implicated genes smoking propensity and DNA repair but further work is required to identify additional LC susceptibility investigate disease development dynamics. We undertaken a family history-based (GWAx) study of LC, analysing 48,843 European cases with parent/sibling compared 195,387 controls from the UK Biobank. This was meta-analysed previously...
1576 Background: Fibrosarcoma (FS) is the second most common group of soft tissue sarcomas in children, however, FS are diagnosed adults. The goal this study was to compare clinical features and outcomes children adults with identify predictors survival. Methods: We have analyzed data from 569 (≤ 19 years) 5,508 (>19 between 1973 2008 (ICCC category IXb) available SEER database. Survival estimates were determined using survival time end point death any cause. Results: Comparison two...
This is initial investigation of gene signatures responsible for adapting microscopic life to the extreme Earth environments. We present preliminary results on identification clusters orthologous groups (COGs) common several hyperthermophiles and exclusion those a mesophile (non-hyperthermophile): Escherichia coli (E. K12), will yield group proteins possibly involved in adaptation under temperatures. Comparative genome analyses represent powerful tool discovery novel genes specific...
Abstract Background There are unexplained geographical variations in the incidence of kidney cancer with high rates reported Baltic countries, as well eastern and central Europe. Analysis non-neoplastic tissues is a way to better understand carcinogenesis. Methods Having access rich, well-annotated collection “tumor/non-tumor” pairs patients from Czech Republic, Romania, Serbia, United Kingdom, Russia for studying genomics cancer, we aimed analyze morphology renal tissue. By applying digital...