A5021044156- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Silk-based biomaterials and applications
- Bee Products Chemical Analysis
- Insect and Pesticide Research
- Insect Pest Control Strategies
- Hormonal Regulation and Hypertension
- Nanoparticles: synthesis and applications
- Neuroblastoma Research and Treatments
- ATP Synthase and ATPases Research
- Environmental Toxicology and Ecotoxicology
- Insect Resistance and Genetics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Studies on Chitinases and Chitosanases
- Forensic Entomology and Diptera Studies
- Biochemical and Structural Characterization
- Insect behavior and control techniques
- Toxoplasma gondii Research Studies
- Phytochemical compounds biological activities
- Pomegranate: compositions and health benefits
- Ion Transport and Channel Regulation
- Insect-Plant Interactions and Control
- Insect symbiosis and bacterial influences
- Chromatin Remodeling and Cancer
- Bacterial Infections and Vaccines
Alexandria University
2012-2025
Bibliotheca Alexandrina
2024
Centre National de la Recherche Scientifique
2006-2022
Université Côte d'Azur
2010-2022
Institut de Pharmacologie Moléculaire et Cellulaire
2007-2022
Umeå University
2014-2021
University of Gothenburg
2016
Agricultural Research Center
2014
Infection et inflammation
2012
St. Jude Children's Research Hospital
2010
MicroRNAs (miRNAs) act at the posttranscriptional level to control gene expression in virtually every biological process, including oncogenesis. Here, we report identification of a set miRNAs that are differentially regulated childhood adrenocortical tumors (ACT), miR-99a and miR-100. Functional analysis these ACT cell lines showed they coordinately regulate insulin-like growth factor-mammalian target rapamycin (mTOR)-raptor signaling pathway through binding sites their 3'-untranslated...
In this study, we shed light for the first time on usage of migratory locusts (Locusta migratoria) as an insect model to investigate nanotoxicological influence aluminum oxide (Al2O3) nanoparticles at low doses testes, and evaluate capacity a whole-body extract American cockroaches (Periplaneta americana) (PAE) attenuate Al2O3 NPs-induced toxicity. Energy dispersive X-ray microanalyzer (EDX) analysis verified bioaccumulation Al in testicular tissues due its liberation from NPs, implying...
Targeting the kinase ERK5 may disrupt activation of an oncogenic transcription factor in a subset neuroblastoma patients.
ABSTRACT The first-in-class inhibitor of ALK, c-MET and ROS1, crizotinib (Xalkori), has shown remarkable clinical efficacy in treatment ALK-positive non-small cell lung cancer. However, neuroblastoma, activating mutations the ALK kinase domain are typically refractory to treatment, highlighting need for more potent inhibitors. next-generation PF-06463922 is predicted exhibit increased affinity mutants prevalent neuroblastoma. We examined activity ALK-driven neuroblastoma models vitro vivo....
High-risk neuroblastoma (NB) is responsible for a disproportionate number of childhood deaths due to cancer.One indicator highrisk NB amplification the neural MYC (MYCN) oncogene, which currently therapeutically intractable.Identification anaplastic lymphoma kinase (ALK) as an oncogene raised possibility using ALK tyrosine inhibitors (TKIs) in treatment patients with activating mutations.8-10% primary are ALK-positive, figure that increases relapsed population.ALK activated by ALKAL2 ligand...
Task1 and Task3 potassium channels (Task: tandem of P domains in a weak inward rectifying K(+) channel-related acid-sensitive channel) are believed to control the membrane voltage aldosterone-producing adrenal glomerulosa cells. This study aimed at understanding role for aldosterone secretion. The phenotype Task3(-/-) mice was investigated using electrophysiology, slices, blood pressure measurements. Primary adrenocortical cells were strongly depolarized compared with wild-type (-52 vs. -79...
Lumpy skin disease (LSD), a of cattle and buffaloes, has recently become widely prevalent in Egypt. The aim this study was to ascertain the potential role Rhipicephalus (Boophilus) annulatus ticks transmission disease. Samples collected from suspected lumpy virus (LSDV) infected cows that had previously been vaccinated with Romanian sheep pox (SPPV) various Egyptian governorates were obtained between May November over two consecutive years, namely 2018 2019. Ticks morphologically identified...
Abstract With the evolution of nanostructure materials, silver nanoparticles (Ag-NPs) emerged as predominantly exploited nanomaterial in multifarious sectors due to their versatile properties. Along with heightening applications Ag-NPs, however, there is increasing concern over indubitable toxicity towards ecosystem, which indeed affects surrounding organisms and human health. In this study, we evaluated detrimental effects Ag-NPs relation Egyptian wild female beetles, Blaps polychresta ,...
Attenuation of adverse effects aflatoxin (AFB1) in brains B1 rats by extracts leaves artichoke was studied. The active ingredients artichoke, Cynara scolymus L., were determined HPLC analysis. In the 42-day experiment, exposed to either sterile water, 4% DMSO, 100 mg leaf extract/kg body mass, 72 μg B1/kg or AFB1 plus extract. Neurotoxicity an increase profile lipids, augmentation plasmatic glucose and concentrations insulin, oxidative stress, increased activities cholinergic enzymes, a...
Abstract This study aims to repurpose sericin in combating non-small lung cancer cells (A549 and H460) by combining it with dactolisib or vitamin D reduce the dose of boost anticancer effectiveness D. Therefore, binding affinities individual combined drugs were examined using silico protein-protein interaction studies, targeting NF-κB, Cyclin D1, p-AKT, VEGF1 proteins. The findings manifested remarkable for combinatorial compared compounds. To substantiate these findings, IC 50 each...
Mice lacking ALK activity have previously been reported to exhibit subtle behavioral phenotypes. In this study of loss function mice we present data supporting a role for in hypogonadotropic hypogonadism male mice. We observed lower level serum testosterone at P40 knock-out males, accompanied by mild disorganization seminiferous tubules exhibiting decreased numbers GATA4 expressing cells. These observations highlight testis and are further supported experiments which chemical inhibition with...
Honeybee products arouse interest in society due to their natural origin and range of important biological properties. Propolis (P) royal jelly (RJ) attract scientists' attention because they exhibit antioxidant, anti-inflammatory, anti-bacterial, anti-tumor, immunomodulatory abilities. In this study, we tested whether P RJ could mitigate the adverse effects cadmium (Cd) exposure, with particular emphasis on reproductive function female rats. line, one week pretreatment was established. Six...
Abstract Hydroxyapatite nanoparticles (HANPs) have been applied in several biomedical fields. However, its interaction with biological systems is less exploited. This study aimed to characterize HANPs, examine their influence on kidneys, and explore the potential protective effects of naturally extracted red pigment (RP) from Monascus purpureus against HANPs-induced renal toxicity. To this aim, forty eight adult male rats were randomly divided into 8 equal groups: a control group receiving...
Abstract BACKGROUND RNA interference (RNAi) targeting the key genes involved in insect growth and development has been demonstrated as pollution‐free green pest management strategies. Double‐stranded (dsRNA)‐based biopesticides offer species‐specific control degrade rapidly environment, making them a safer alternative to conventional chemical pesticides. However, efficient delivery of dsRNA is significant challenge application RNAi technology for management. RESULTS Chitosan, natural...
Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion that requires proper spatial and temporal coordination proliferation, fate determination, differentiation morphogenesis. This probably relies on complex interplay between mechanisms control cell cycle, specification differentiation. In this respect, we have studied the possible implication GATA2, transcription factor is involved several neuronal pathways, proliferation neural embryonic spinal cord....