Susanne M. Arnold
A5030064179- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Genetic Associations and Epidemiology
- Neuroblastoma Research and Treatments
- Nutritional Studies and Diet
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Brain Metastases and Treatment
- Glutathione Transferases and Polymorphisms
- BRCA gene mutations in cancer
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- HER2/EGFR in Cancer Research
- Neutropenia and Cancer Infections
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- DNA Repair Mechanisms
University of Kentucky
2016-2025
Helmholtz Centre for Environmental Research
2022-2025
Markey Cancer Center
2015-2024
Albert B. Chandler Hospital
1999-2021
Radboud University Nijmegen
2020-2021
Radboud University Medical Center
2020-2021
Radboud Institute for Molecular Life Sciences
2020-2021
University Medical Center
2020-2021
Lexington VA Health Care System
2002-2021
Archäologisches Landesmuseum Baden-Württemberg
2016-2021
Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of confounding effect tobacco. Mendelian randomization (MR), or use genetic instrumental variables to assess causality, may help identify drivers cancer. Methods findings We identified instruments for potential risk factors evaluated these in relation using 29,266 cases (including 11,273 adenocarcinomas, 7,426 squamous cell 2,664 small cases) 56,450 controls. The MR analysis suggested a...
The gene that produces the precursor RNA transcript to three largest structural rRNA molecules (rDNA) is present in multiple copies and organized into clusters. 10 human rDNA clusters represent <0.5% of diploid genome but are critically important for cellular viability. Individual genes within possess very high levels sequence identity with respect each other local concentration, making them ideal substrates genomic rearrangement driven by dysregulated homologous recombination. We recently...
At the time of cancer diagnosis, body mass index (BMI) is inversely correlated with lung risk, which may reflect reverse causality and confounding due to smoking behavior. We used two-sample univariable multivariable Mendelian randomization (MR) estimate causal relationships BMI behaviors on histological subtypes based an aggregated genome-wide association studies (GWASs) analysis in 29 266 cases 56 450 controls. observed a positive effect for high occurrence small-cell (odds ratio (OR) =...
Abstract Quantifying the genetic correlation between cancers can provide important insights into mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six types based on a total of 296,215 cases and 301,319 controls European ancestry, here we estimate pair-wise correlations breast, colorectal, head/neck, lung, ovary prostate cancer, 38 other diseases. We observed statistically significant lung head/neck ( r g = 0.57, p 4.6 × 10 −8 ), breast ovarian...
Abstract Lung cancer is the leading cause of cancer-related death globally. An improved risk stratification strategy can increase efficiency low-dose CT (LDCT) screening. Here we assessed whether individual's genetic background has clinical utility for in context LDCT On basis 13,119 patients with lung and 10,008 controls European ancestry International Cancer Consortium, constructed a polygenic score (PRS) via 10-fold cross-validation regularized penalized regression. The performance model...
Abstract Cancer is one of the leading causes death, and there an urgent need for new biomarkers therapeutic targets. The progesterone receptor membrane component 1 (Pgrmc1) protein upregulated in multiple types cancer, Pgrmc1 required tumor cell proliferation, motility formation vivo . Furthermore, a small molecule inhibitor suppressed growth lung, breast cervical cancer lines. Recently, was identified as sigma‐2 receptor, putative type opioid receptors are induced cancers. However, shares...
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, pathogenic pathways, through which SNPs within affects cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and expression quantitative trait loci (eQTL) on 409 to identify validate underlying pathways investigate combined effect of genes from pathways. The KEGG neuroactive ligand receptor...
Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung etiology via direct measurements pre-diagnostic circulating concentrations a nested case-control study, complemented with Mendelian randomization (MR) approach an independent sample. used biomarker data from 5183 pairs within 20 prospective cohorts, and genetic 29,266 cases 56,450 controls. Exposures included directly measured blood samples 8 single...
Importance Oral tongue cancer (OTC) incidence has increased rapidly among young (&amp;lt;50 years) non-Hispanic White individuals in the US during past 2 decades; however, it is unknown if age-associated trajectories have persisted. Objective To examine trends OTC and project future case burden. Design, Setting, Participants This cross-sectional analysis of used Cancer Statistics Public Use Database, which covers approximately 98% population, included with an diagnosis reported to...
// Rachel L. Stewart 1, 2 , Brittany Carpenter 3 Dava S. West Teresa Knifley 1 Lili Liu 4 Chi Wang 5 Heidi Weiss Tamas Gal 6 Eric B. Durbin Susanne M. Arnold Kathleen O'Connor Min Chen 7 Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA Department Pathology and Laboratory Medicine, Molecular Cellular Biochemistry, Toxicology, Guangdong Province Hospital for Occupational Disease Prevention Treatment, Guangzhou, Guangdong, 510300, PR China Biostatistics, Division...
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal our study has been to integrate complete results with a large‐scale expression quantitative trait loci (eQTL) mapping in human tissues ( n = 1,038) identify candidate causal genes for cancer. performed transcriptome‐wide association (TWAS) overall, by histology (adenocarcinoma, squamous cell carcinoma small cancer) smoking subgroups (never‐ ever‐smokers)....