A5063230233- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Viral-associated cancers and disorders
- Folate and B Vitamins Research
- Tea Polyphenols and Effects
- Cancer Risks and Factors
- Genomics, phytochemicals, and oxidative stress
- Respiratory viral infections research
- Glutathione Transferases and Polymorphisms
- Smoking Behavior and Cessation
- Nutrition and Health in Aging
- Telomeres, Telomerase, and Senescence
- Pancreatic and Hepatic Oncology Research
- Phytoestrogen effects and research
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Carcinogens and Genotoxicity Assessment
- Nutrition, Genetics, and Disease
- Advanced machining processes and optimization
- Cancer survivorship and care
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
University of Pittsburgh Medical Center
2020-2025
UPMC Hillman Cancer Center
2016-2025
Xian Central Hospital
2024-2025
National Taiwan University
2021-2025
Shanghai University of Sport
2010-2024
University of Pittsburgh
2014-2024
Harbin Engineering University
2024
Jishou University
2024
Shandong University
2019-2023
National Cancer Institute
2021
Most studies that have evaluated the association between body-mass index (BMI) and risks of death from any cause specific causes been conducted in populations European origin.We performed pooled analyses to evaluate BMI risk among more than 1.1 million persons recruited 19 cohorts Asia. The included approximately 120,700 deaths occurred during a mean follow-up period 9.2 years. Cox regression models were used adjust for confounding factors.In East Asians, including Chinese, Japanese,...
Background Elevated serum homocysteine is associated with an increased risk of cardiovascular disease (CVD). This may reflect a reduced systemic remethylation capacity, which would be expected to cause decreased genomic DNA methylation in peripheral blood leukocytes (PBL). Methodology/Principal Findings We examined the association between prevalence CVD (myocardial infarction, stroke) and its predisposing conditions (hypertension, diabetes) PBL global as represented by ALU Satellite 2 (AS)...
Background The occurrence of diabetes has greatly increased in low- and middle-income countries, particularly Asia, as the prevalence overweight obesity; European-derived populations, obesity are established causes diabetes. shape association with risk its overall impact have not been adequately studied Asia. Methods Findings A pooled cross-sectional analysis was conducted to evaluate between baseline body mass index (BMI, measured weight kg divided by square height m) self-reported status...
Colorectal cancer (CRC) is a major contributor to death globally. Several studies showed some protections by certain individual dietary antioxidants against CRC development. Epidemiologic data on the composite antioxidant index (CDAI) in relation risk are sparse. Using Singapore Chinese Health Study, an ongoing prospective cohort consisting of 61 321 cancer-free participants aged 45 74 years at baseline, food-based CDAI was calculated according previously established and validated method...
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (sum of which is denoted as total NNAL) are metabolites 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNK NNAL can induce lung cancer in laboratory animals but human data limited. The association between prediagnostic levels urinary risk development was evaluated two prospective cohorts Chinese cigarette smokers. We conducted a nested case-control study involving 246 cases incident 245 cohort controls who were...
Prospective data on environmental exposures, especially with respect to alcohol, tobacco, and diet, in relation the risk of esophageal cancer high-risk populations are sparse. We analyzed from a population-based cohort 18,244 middle-aged older men Shanghai identify factors for this population. The was followed through 2006, 101 incident cases were identified. Cox proportional hazards models used estimate hazard ratios (HR) their corresponding 95% confidence intervals (CI) associations...
Background Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, parts which men's prevalence among world's highest. Methods and Findings performed pooled analyses data from 1,049,929 participants 21 cohorts Asia risks total cause-specific mortality associated with tobacco using adjusted hazard ratios their 95% confidence intervals. then estimated smoking-related adults aged ≥45 y 2004 Bangladesh, India, mainland...
<h3>Importance</h3> Asia is home to the largest diabetic populations in world. However, limited studies have quantified association of diabetes with all-cause and cause-specific mortality Asian populations. <h3>Objectives</h3> To evaluate investigate potential effect modifications diabetes-mortality associations by participants’ age, sex, education level, body mass index, smoking status. <h3>Design, Setting, Participants</h3> This pooled analysis incorporated individual participant data from...
Abstract Background: Epidemiologic findings of tobacco and alcohol use in relation to gastric cancer are inconsistent. Well-designed prospective studies examining their relationship sparse. Methods: The association between cigarette smoking/alcohol intake risk was examined a population-based cohort 18,244 middle-aged older men Shanghai, China, who were enrolled the study during 1986-1989. After up 20 years follow-up, 391 incident cases identified. Cox proportional hazards regression models...
The study aimed to assess whether aerobic exercise (AEx) training and a fibre-enriched diet can reduce hepatic fat content (HFC) increase glycaemic control in pre-diabetic patients with non-alcoholic fatty liver disease (NAFLD). Six-hundred-and-three from seven clinics Yangpu district, Shanghai, China were recruited. Of them 115 individuals aged 50-65-year fulfilled the inclusion criteria (NAFLD impaired fasting glucose or tolerance) randomly assigned into (AEx n = 29), (Diet 28), plus (AED...
Abstract Epidemiologic and animal studies suggest a protective role of green tea against breast cancer. However, the underlying mechanism is not understood. We conducted randomized, double-blinded, placebo-controlled phase II clinical trial to investigate whether supplementation with extract (GTE) modifies mammographic density (MD), as potential mechanism, involving 1,075 healthy postmenopausal women. Women assigned treatment arm consumed daily 4 decaffeinated GTE capsules containing 1,315...
Abstract Identification of risk biomarkers may enhance early detection smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis 731 smoking-matched case-control sets nested within six prospective cohorts from the US, Europe, Singapore, Australia. identify 36 with independently reproducible associations imminent cancer (all p < 4 × 10 −5 ). These include a few markers (e.g. CA-125/MUC-16 CEACAM5/CEA) that have...
Abstract Currently, the relationship between serum uric acid (SUA) and bone mineral density (BMD) in men remains controversial. This study aims to investigate SUA lumbar spine BMD American using data from National Health Nutrition Examination Survey (NHANES). A total of 6254 male subjects aged 12–80 years (mean age 35.52 ± 14.84 years) NHANES 2011 2020 were analyzed. was measured by DxC timed endpoint method, dual-energy X-ray absorptiometry (DXA). Multivariate linear regression models used...
OBJECTIVE Asian populations are documenting rapid increases in the rates of diabetes and hip fracture, but there no prospective data linking both diseases studies. We investigated this association among a cohort Chinese Singapore. RESEARCH DESIGN AND METHODS A 63,257 Singapore Health Study, established between 1993 1998, was followed up for mean duration 12 years. Diabetes status ascertained by baseline interviews, incidence fracture post-enrollment identified through nationwide hospital...
Polycyclic aromatic hydrocarbons (PAH) are believed to be among the principal causative agents for lung cancer in smokers, but no epidemiologic studies have evaluated relationship of PAH uptake and metabolism cancer. In this study, we quantified prediagnostic urinary levels r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), a validated biomarker metabolism, as well 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol its glucuronides (total NNAL), cotinine cotinine), biomarkers...
Abstract Background: Mitochondria are eukaryotic organelles responsible for energy production. Quantitative changes in human mitochondrial DNA (mtDNA) copy number have been implicated various cancer types. Data from prospective cohort studies on mtDNA and colorectal risk lacking. Methods: We evaluated the association between peripheral blood a nested case–control study of 422 cases (168 with pre-diagnostic 254 post-diagnostic blood) 874 controls who were free among participants Singapore...