A5058346905- Arsenic contamination and mitigation
- Genetic and phenotypic traits in livestock
- Heavy Metal Exposure and Toxicity
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Carcinogens and Genotoxicity Assessment
- Animal Nutrition and Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Meat and Animal Product Quality
- DNA Repair Mechanisms
- Animal Behavior and Welfare Studies
- Cardiovascular Health and Disease Prevention
- Occupational and environmental lung diseases
- Nutritional Studies and Diet
- Glutathione Transferases and Polymorphisms
- Fluoride Effects and Removal
- Animal Genetics and Reproduction
- Trace Elements in Health
- Adipose Tissue and Metabolism
- Molecular Biology Techniques and Applications
- Genomics and Phylogenetic Studies
- Environmental Justice and Health Disparities
- Effects of Environmental Stressors on Livestock
- Microbial Metabolism and Applications
- Diabetes Management and Research
New York University
2015-2024
Zhejiang University
2018-2024
Anhui University
2023
Arkansas Department of Agriculture
2020
Population Council
2019
Yichang Central People's Hospital
2018
Fundación Española de la Nutrición
2017
NYU Langone Health
2016
Fudan University
2007-2013
Zhengzhou University
2010
A longitudinal study of intestinal microbiota in children and their mothers shows that antibiotics, cesarean section, infant formula alter patterns microbial acquisition succession during the first 2 years childhood.
Background: Few prospective studies have evaluated the influence of arsenic methylation capacity on cardiovascular disease (CVD) risk.Objective: We association exposure from drinking water and with CVD risk.Method: conducted a case–cohort study 369 incident fatal nonfatal cases CVD, including 211 heart 148 stroke, subcohort 1,109 subjects randomly selected 11,224 participants in Health Effects Arsenic Longitudinal Study (HEALS).Results: The adjusted hazard ratios (aHRs) for all disease,...
Occupational exposure to nickel (Ni) is associated with an increased risk for lung and nasal cancers. Ni compounds exhibit weak mutagenic activity, cause gene amplification, disrupt cellular epigenetic homeostasis. However, the Ni-induced changes in global histone modification levels have only been tested vitro.This study was conducted a Chinese population determine whether occupational alterations of evaluate inter- intraindividual variance levels.Forty-five subjects 75 referents were...
Abstract Pigs not only function as a major meat source worldwide but also are commonly used an animal model for studying human complex traits. A large haplotype reference panel has been to facilitate efficient phasing and imputation of relatively sparse genome-wide microarray chips low-coverage sequencing data. Using the imputed genotypes in downstream analysis, such GWASs, TWASs, eQTL mapping genomic prediction (GS), is beneficial obtaining novel findings. However, currently, there still...
Abstract Introduction Epidemiological studies that investigate alterations in the gut microbial composition associated with smoking are lacking. This study examined of microbiome smokers compared nonsmokers. Aims and Methods Stool samples were collected a cross-sectional 249 participants selected from Health Effects Arsenic Longitudinal Study Bangladesh. Microbial DNA was extracted fecal sequenced by 16S rRNA gene sequencing. The associations status intensity relative abundance or absence...
Myotonia is a condition characterized by impaired relaxation of muscle following sudden forceful contraction. We systematically screened all 23 exons the CLCN1 gene in 88 unrelated patients with myotonia and identified mutations 14 patients. Six novel were discovered: five missense (S132C, L283F, T310M, F428S T550M) found heterozygous patients, one was nonsense mutation (E193X) homozygous patient. While had clinical diagnosis congenita, patient exhibited symptoms characteristic paramyotonia...
Our objective was to investigate the relationship between gut microbiota and anthropometric measurements among 248 participants from Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. cohort represents a unique population that allows for investigation lean individuals. We measured height, weight, arm, thigh, hip, waist circumferences, collected fecal samples. Microbial DNA extracted stool samples sequenced by 16S rRNA gene sequencing. examined associations relative abundance...
The research on genetic characterization of Chinese indigenous pig breeds is essential to promote scientific conservation and sustainable development pigs. Here, we systematically surveyed the genomes 75 unrelated Diannan small-ear (DSE) pigs that were from 3 diverse regions (Yingjiang County, Jinping County Sipsongpanna in Yunnan Province) describe their population structure, diversity, inbreeding coefficient, selection signatures. First, these individuals sequenced genotyped following...
Abstract Colonization of specific bacteria in the human mouth was reported to be associated with gastric cancer risk. However, previous studies were limited by retrospective study designs and low taxonomic resolutions. We performed a prospective case‐control nested within three cohorts investigate relationship between oral microbiome Shotgun metagenomic sequencing employed characterize prediagnostic buccal samples from 165 cases 323 matched controls. Associations overall microbial richness...
Lack of Association between Cytokine Gene Polymorphisms and Silicosis Pulmonary Tuberculosis in Chinese Iron Miners: Fen W u , et al . Department Occupational Health Toxicology, School Public Health, Fudan University, China —Silicosis is a fibrotic lung disease produced by the inhalation deposition silica dust. The association silicosis pulmonary tuberculosis (PTB) has been well established. Cytokines participate development progression PTB. Functional polymorphisms cytokine genes have...
Emerging data suggest that inorganic arsenic exposure and gut microbiome are associated with the risk of cardiovascular disease. The may modify disease exposure. Our aim was to examine inter-relationships between exposure, microbiome, carotid intima-media thickness (IMT)—a surrogate marker for atherosclerosis. We recruited 250 participants from Health Effects Arsenic Longitudinal Study in Bangladesh, measured IMT collected fecal samples year 2015–2016. 16S rRNA gene sequencing conducted on...
Background: Epidemiologic data on genetic susceptibility to cardiovascular effects of arsenic exposure from drinking water are limited.Objective: We investigated whether the association between well-water and disease (CVD) differed by 170 single nucleotide polymorphisms (SNPs) in 17 genes related metabolism, oxidative stress, inflammation, endothelial dysfunction.Method: conducted a prospective case-cohort study nested Health Effects Arsenic Longitudinal Study, with random subcohort 1,375...
Background: Chronic exposure to inorganic arsenic from drinking water has been associated with a host of cancer and noncancer diseases. The application metabolomics in epidemiologic studies may allow researchers identify biomarkers its health effects. Objective: Our goal was evaluate the long-term reproducibility urinary metabolites associations between reproducible exposure. Methods: We studied samples data 112 nonsmoking participants (58 men 54 women) who were free any major chronic...
To evaluate the potential effects of betel quid chewing on mortality. (A consists nut, wrapped in leaves; tobacco is added to by some users).
This study was aimed to explore the crucial genes and microRNAs (miRNAs) associated with carotid atherosclerosis (CA). Two public datasets GSE28829 GSE43292 were obtained from Gene Expression Omnibus databases analyze differentially expressed (DEGs) between primary advanced atherosclerotic plaque tissues. The Ontology (GO) terms, pathways, protein–protein interactions (PPIs) of these DEGs analyzed. miRNAs transcription factor (TF) predicted. A total 112 upregulated 179 downregulated...
It is widely accepted that the cytotoxicity and genotoxicity of benzene results from action reactive metabolites. Therefore, genetic variation in metabolic enzyme genes may contribute to susceptibility chronic poisoning (CBP) exposed population. Using a case–control study included 268 benzene-poisoned patients workers occupationally South China, we aimed investigate association between single-nucleotide polymorphisms with phase I II metabolism risk CBP. The TaqMan technique was used detect...
Vinyl chloride (VC) was classified as a group 1 carcinogen by IARC in 1987. Although the relationship between VC exposure and liver cancer has been established, mechanism of VC-related carcinogenesis remains largely unknown. Previous epidemiological studies have shown that is associated with increased genotoxicity humans. To explore chromosomal damage its progression, their association to genetic susceptibility, we investigated 402 workers exposed VC, 77 VC-exposed cohort 141 unexposed...