Muhammad G. Kibriya
A5081425275- Arsenic contamination and mitigation
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Heavy Metal Exposure and Toxicity
- Nutrition, Genetics, and Disease
- Telomeres, Telomerase, and Senescence
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Air Quality and Health Impacts
- Retinoids in leukemia and cellular processes
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Genetic factors in colorectal cancer
- Health, Environment, Cognitive Aging
- Global Cancer Incidence and Screening
- Colorectal Cancer Treatments and Studies
- Gene expression and cancer classification
- Folate and B Vitamins Research
- Genomic variations and chromosomal abnormalities
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Climate Change and Health Impacts
- Molecular Biology Techniques and Applications
Chicago Department of Public Health
2016-2025
University of Chicago
2016-2025
Agostino Gemelli University Polyclinic
2022
Institut Pasteur de Lille
2022
Centre Hospitalier Universitaire de Lille
2022
Cedars-Sinai Medical Center
2022
Thermo Fisher Scientific (Sweden)
2020
University of Illinois Chicago
2017-2019
National Cancer Institute
2014
Stanford University
2014
Telomere length within an individual varies in a correlated manner across most tissues.
Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased postmenopausal women. It unclear whether this association mediated through shared genetic or environmental factors.
Abstract Here we show that FTO as an N 6 -methyladenosine (m A) RNA demethylase is degraded by selective autophagy, which impaired low-level arsenic exposure to promote tumorigenesis. We found in arsenic-associated human skin lesions, upregulated, while m A methylation downregulated. In keratinocytes, chronic relevant upregulated FTO, downregulated methylation, and induced malignant transformation deletion inhibited arsenic-induced Moreover, mice, epidermis-specific prevented tumorigenesis...
Abstract We conducted a case-control study to investigate interindividual variability in susceptibility health effects of inorganic arsenic due metabolism efficiency, genetic factors, and their interaction. A total 594 cases arsenic-induced skin lesions 1,041 controls was selected from baseline participants large prospective cohort Bangladesh. Adjusted odds ratios (OR) for were estimated relation the polymorphisms glutathione S-transferase ω1 methylenetetrahydrofolate reductase genes,...
Alterations in DNA methylation frequently occur hepatocellular cancer (HCC). We have previously demonstrated that hypermethylation candidate genes can be detected plasma before HCC diagnosis. To identify, with a genome-wide approach, additional hypermethylated could used for more accurate analysis of early diagnosis, we analyzed tumor and adjacent nontumor tissues from 62 Taiwanese cases using Illumina arrays (Illumina, Inc., San Diego, CA) screen 26,486 autosomal CpG sites. After Bonferroni...
Arsenic contamination of drinking water is a major public health issue in many countries, increasing risk for wide array diseases, including cancer. There inter-individual variation arsenic metabolism efficiency and susceptibility to toxicity; however, the basis this not well understood. Here, we have performed first genome-wide association study (GWAS) arsenic-related toxicity phenotypes improve our understanding mechanisms by which affects health. Using data on urinary metabolite...
Hepatocellular carcinoma (HCC) incidence has increased in the US and also one of fastest growing death rates any cancer. The purpose current study was to discover novel genome-wide aberrant DNA methylation patterns HCC tumors that are predominantly HCV-related. Infinium HumanMethylation 450K BeadChip arrays were used examine profiles 66 pairs tumor adjacent non-tumor tissues. After Bonferroni adjustment, a total 130,512 CpG sites significantly differed level compared with tissues, 28,017...
Abstract Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) identify loci. Findings were replicated in independent (55,789 330,490 controls). identified novel at 1q22 involving breast lung squamous cell carcinoma, eQTL analysis showing an...
A large fraction of human genes are regulated by genetic variation near the transcribed sequence (cis-eQTL, expression quantitative trait locus), and many cis-eQTLs have implications for disease. Less is known regarding effects on distant (trans-eQTLs) their biological mechanisms. In this work, we use genome-wide data SNPs array-based measures from mononuclear cells obtained a population-based cohort 1,799 Bangladeshi individuals to characterize cis- trans-eQTLs determine if observed...
Inherited genetic variation affects local gene expression and DNA methylation in humans. Most quantitative trait loci (cis-eQTLs) occur at the same genomic location as a QTL (cis-meQTL), suggesting common causal variant shared mechanism. Using RNA from peripheral blood of Bangladeshi individuals, here we use co-localization methods to identify eQTL-meQTL pairs likely share variant. We partial correlation mediation analyses >400 these showing evidence relationship between (i.e., mechanism)...
Early-onset breast cancer (EOBC) causes substantial loss of life and productivity, creating a major burden among women worldwide. We analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) discovery set 3,523 EOBC incident cases 2,702 population control ages ≤ 51 years. The SNPs with smallest P values were examined in replication 3,470 5,475 women. also tested association 19,684 genes by annotating each gene putative functional SNPs, then combining their to obtain gene-based value....
To our knowledge, fecal microbiota collection methods have not been evaluated in low- and middle-income countries. Therefore, we five different sample for technical reproducibility, stability, accuracy within the Health Effects of Arsenic Longitudinal Study (HEALS) Bangladesh. Fifty participants from HEALS provided samples clinic which were aliquoted into no solution, 95% ethanol, RNAlater, postdevelopment occult blood test (FOBT) cards, immunochemical (FIT) tubes. Half aliquots frozen...
Background: Inorganic arsenic is one of the most common naturally occurring contaminants found in environment. Arsenic associated with a number health outcomes, epigenetic modification suggested as potential mechanism toxicity.Objective: Among sample 400 adult participants, we evaluated association between exposure, measured by blood and urinary total concentrations, epigenome-wide white cell DNA methylation.Methods: We used linear regression models to examine associations exposure...
We performed a genome-wide scan of 27,578 CpG loci covering 14,475 genes to identify differentially methylated (DML) in colorectal carcinoma (CRC). used Illumina's Infinium methylation assay paired DNA samples extracted from 24 fresh frozen CRC tissues and their corresponding normal colon consecutive diagnosed patients at tertiary medical center. found total 627 DML 513 genes, which 535 are novel 465 genes. also validated the Illumina data for top-ranking by non-bisulfite conversion...
The authors conducted a cross-sectional study to assess the relation between arsenic exposure from drinking water and plasma levels of markers systemic inflammation endothelial dysfunction (matrix metalloproteinase-9, myeloperoxidase, plasminogen activator inhibitor-1, soluble E-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular (VCAM-1)) using baseline data 668 participants (age, >30 years) in Health Effects Arsenic Longitudinal Study Bangladesh (2007–2008). Both well urinary...
Mature microRNAs (miRNAs) are a class of small non-coding RNAs involved in posttranslational gene silencing. Previous studies found that downregulation miRNAs is common feature observed solid tumors, including hepatocellular carcinoma (HCC). We employed genome-wide approach to test the hypothesis DNA methylation alterations miRNA host genes may cause deregulated expression HCC. analyzed tumor and adjacent non-tumor tissues from 62 Taiwanese HCC cases using Infinium HumanMethylation27...
We examined whether differences in tumor DNA methylation were associated with more aggressive hormone receptor-negative breast cancer an ethnically diverse group of patients the Breast Cancer Care Chicago (BCCC) study and using data from The Genome Atlas (TCGA). was extracted formalin-fixed, paraffin-embedded samples on 75 (21 White, 31 African-American, 23 Hispanic) (training dataset) enrolled BCCC. Hormone receptor status defined as negative if tumors for both estrogen progesterone (ER/PR)...
Animal studies suggest that exposure to pesticides may alter thyroid function; however, few epidemiologic have examined this association. We evaluated the relationship between individual and function in 679 men enrolled a substudy of Agricultural Health Study, cohort licensed pesticide applicators.
Abstract Introduction Epidemiological studies that investigate alterations in the gut microbial composition associated with smoking are lacking. This study examined of microbiome smokers compared nonsmokers. Aims and Methods Stool samples were collected a cross-sectional 249 participants selected from Health Effects Arsenic Longitudinal Study Bangladesh. Microbial DNA was extracted fecal sequenced by 16S rRNA gene sequencing. The associations status intensity relative abundance or absence...
ABSTRACT Telomere shortening is a hallmark of aging. length (TL) in blood cells has been studied extensively as biomarker human aging and disease; however, little known regarding variability TL non-blood, disease-relevant tissue types. Here we characterize measurements for 6,391 samples, representing >20 types 952 individuals from the Genotype-Tissue Expression (GTEx) Project. We describe differences across types, positive correlation among associations with age ancestry. show that...
Background: DNA methylation (DNAm) data from human samples has been leveraged to develop "epigenetic clock" algorithms that predict age and other aging-related phenotypes. Some DNAm clocks were trained using obtained blood cells, while diverse tissue/cell types. To assess how perform across non-blood tissue types, we applied generated 9 different Methods: We array-based measurements for 973 deceased donors the GTEx (Genotype Tissue Expression) project representing nine distinct types: lung,...