A5073154509- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Medical Imaging and Pathology Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Eosinophilic Esophagitis
- Stochastic processes and financial applications
- Pharmaceutical Practices and Patient Outcomes
- Advanced Proteomics Techniques and Applications
- Analytical Chemistry and Chromatography
- Economic and Financial Impacts of Cancer
- Kruppel-like factors research
- Global Cancer Incidence and Screening
- Nutrition and Health in Aging
- Pain Management and Opioid Use
- PI3K/AKT/mTOR signaling in cancer
- Silymarin and Mushroom Poisoning
- Colorectal Cancer Screening and Detection
- Risk and Portfolio Optimization
University of Washington
2024
Weill Cornell Medicine
2018-2023
Cornell University
2015-2023
Kaiser Permanente Fontana Medical Center
2023
Kaiser Permanente
2022
Seattle Cancer Care Alliance
2017
Fred Hutch Cancer Center
2017
University of Washington Medical Center
2017
Cancer Research Center
2017
McGill University
2016
Hepatocellular carcinoma (HCC) incidence has increased in the US and also one of fastest growing death rates any cancer. The purpose current study was to discover novel genome-wide aberrant DNA methylation patterns HCC tumors that are predominantly HCV-related. Infinium HumanMethylation 450K BeadChip arrays were used examine profiles 66 pairs tumor adjacent non-tumor tissues. After Bonferroni adjustment, a total 130,512 CpG sites significantly differed level compared with tissues, 28,017...
The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by the catabolism of stored nutrients in skeletal muscle and adipose tissue that particularly prevalent nonsmall cell lung (NSCLC). Loss results functional impairments increased mortality. aim present study was to characterize changes metabolism genetically engineered mouse model NSCLC. We show portion these animals develop loss muscle, tissue, inflammatory markers mirroring human syndrome. Using noncachexic...
KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD), and activating mutations co-occur with loss-of-function TP53 or STK11/LKB1. However, mutation of all three genes rarely observed hLUAD, even though engineered comutation highly aggressive mouse adenocarcinoma (mLUAD). Here, we provide a mechanistic explanation for this difference by uncovering an evolutionary divergence regulation triosephosphate isomerase (TPI1). In TPI1 activity regulated via...
Background. Physician awareness of their patients' use complementary and alternative medicine (CAM) is crucial, particularly in the setting a potentially life-threatening disease such as cancer. The potential for harmful treatment interactions may be greatest when patient sees CAM practitioner—perceived physician-like authority figure—but does not disclose this to physician. Therefore, study investigated extent nondisclosure large cohort cancer patients. Methods. participants UCSD Women's...
Highlights•The components of the DIPPS plus classification have prognostic relevance after adjustment by DIPSS classification.•Higher risk is associated with inferior survival and higher both relapse treatment-related mortality.AbstractHematopoietic cell transplantation (HCT) provides potentially curative treatment for patients myelofibrosis (MF). HCT outcomes are Dynamic International Prognostic Scoring System (DIPSS) scores. In present study we analyzed results in 233 to determine if...
Recently surpassing heart disease, cancer is now the leading cause of death (one in four) United States. Worldwide, control becoming increasingly important as life expectancy improves because lower infant mortality and fewer deaths from infectious diseases. Morbidity many forms can be controlled through primary or secondary prevention. Primary prevention defined risk modification to occurrence. Secondary refers use screening tests detect cancers at early stages. Environmental carcinogens,...
Purpose. To determine the maximum tolerated dose per day of silybin phosphatidylcholine (Siliphos) in patients with advanced hepatocellular carcinoma (HCC) and hepatic dysfunction. Experimental Design. Patients HCC not eligible for other therapies based on poor function were enrolled a phase I study phosphatidylcholine. A standard design was used 4 planned cohorts, escalating from 2, 4, 8, to 12 g divided doses weeks. Results. Three participants this single institution trial. All subjects...
Recently surpassing heart disease, cancer is now the leading cause of death (one in four) United States. Worldwide, control becoming increasingly important as life expectancy improves because lower infant mortality and fewer deaths from infectious diseases. Morbidity many forms can be controlled through primary or secondary prevention. Primary prevention defined risk modification to occurrence. Secondary refers use screening tests detect cancers at early stages. Environmental carcinogens,...
The objectives of option hedging/trading extend beyond mere protection against downside risks, with a desire to seek gains also driving agent's strategies. In this study, we showcase the potential robust risk-aware reinforcement learning (RL) in mitigating risks associated path-dependent financial derivatives. We accomplish by leveraging policy gradient approach that optimises performance criteria. specifically apply methodology hedging barrier options, and highlight how optimal strategy...
The objectives of option hedging/trading extend beyond mere protection against downside risks, with a desire to seek gains also driving agent's strategies. In this study, we showcase the potential robust risk-aware reinforcement learning (RL) in mitigating risks associated path-dependent financial derivatives. We accomplish by leveraging policy gradient approach that optimizes performance criteria. specifically apply methodology hedging barrier options, and highlight how optimal strategy...
Objective: To explore the prevalences of JAK2, CALR and MPL gene mutations mutation types in patients with Philadelphia chromosome negative myeloproliferative neoplasms (MPNs) , to compare their clinical characteristics different each other group. Methods: The JAK2 V617F, at exon 12, 9 10 1 648 Ph MPNs were detected by direct sequencing. Results: ① JAK2V617F was found 471 (92.7%) 508 PV patients, 819 (78.1%) 049 ET 74 (81.3%) 91 PMF respectively, total rate as 82.8% (1 364/1 648) . exon12...
9593 Background: Medication adherence can help improve disease progression and survival. One way to is facilitate ease of administration, i.e., oral vs. intravenous. Our study veterans with hepatocellular cancer (HCC) on Sorafenib therapy aimed assess the factors that affect overall Methods: A retrospective analysis national level data from 2007 2013 collected by 120 VA medical centers across country diagnosing treating patients was used for study. Data age at diagnosis, gender, race,...
Background Lower socioeconomic status (SES) affects health care delivery and is associated with worse outcomes. Integrated healthcare systems (IHS) may help reduce barriers to affect Our aim was compare outcomes of colon cancer cases diagnosed at the largest IHS in California, Kaiser Permanente Southern California (KPSC), other insured patients (OI) determine how SES influences mortality. Methods This retrospective cohort study included adults southern between 2009 2014, using data from...
Abstract Hotspot thermal profiling (HTP) methods utilize modified-peptide level information in order to interrogate proteoform-specific stability inside of live cells. The first demonstration HTP involved the integration phosphopeptide enrichment into a TMT-based, single-LC separation workflow 1 . Here we present new ‘label-fractionate-enrich’ (LFE)-HTP method that involves high-pH reverse phase fractionation TMT-labeled peptides prior enrichment, followed by peptide detection and...