A5101887421- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Polyomavirus and related diseases
- Mesenchymal stem cell research
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Complement system in diseases
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Platelet Disorders and Treatments
- Mycobacterium research and diagnosis
- Hematological disorders and diagnostics
- Renal Transplantation Outcomes and Treatments
- T-cell and Retrovirus Studies
- Transplantation: Methods and Outcomes
- Neutropenia and Cancer Infections
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
First Affiliated Hospital of Soochow University
2015-2024
Soochow University
2015-2024
Guangzhou Blood Center
2018
Xi'an Peihua University
2004
Abstract In the Asia‐Pacific region, treatment options are limited for patients with relapsed/refractory chronic lymphocytic leukemia ( CLL )/small lymphoma SLL ). Rituximab is widely used in this setting when purine analog‐based therapies not appropriate. We evaluated efficacy and safety of ibrutinib compared rituximab a randomized, open‐label phase 3 study predominantly Asian / . Patients N = 160) were randomly assigned 2:1 to receive 420 mg n 106) until disease progression PD ) or...
Two large living nematodes were removed from the peritoneal cavity of a 17-year-old youth complaining intense abdominal pain in right lower quadrant. The worms measured 55 and 59 mm length identified as fourth-stage larvae Eustrongylides. patient gave history swallowing live minnows while fishing.
The role of Th17 cells and Th17-associated cytokines in the development acute graft-versus-host disease (aGVHD) clinical allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients is not well established. In current study, a cohort 69 allo-HSCT patients was examined for percentages FoxP3+ Treg expressions RORγt FoxP3 peripheral blood mononuclear (PBMCs). percentage expression were significantly higher, whereas lower severe aGVHD (grade 3 to 4) mild 1 2) than without 0) healthy...
Abstract Tyrosine kinase inhibitors (TKIs) have revolutionized Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL) treatment. The combination of blinatumomab and a TKI in the frontline setting has shown safety efficacy chemotherapy‐free treatment approach patients with Ph + ALL. This retrospective analysis included 19 ALL Ph‐like treated TKI. Of 14 newly diagnosed patients, overall response, complete remission (CR), molecular response (CMR) rates after one cycle were...
We analyzed the outcomes of 44 patients with paroxysmal nocturnal hemoglobinuria (PNH) who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) (haploidentical [haplo]-donors, 25; matched sibling donors [MSDs], 15; and unrelated donors, 4) between July 2007 May 2018. All achieved successful donor engraftment. The median time was 12 days (range, 7 to 26) for myeloid engraftment 13 11 75) platelets. cumulative incidences were 15.91% 2.27% grades II IV III acute...
Graft-versus-host disease (GVHD), leukemia relapse, and immune deficiency remain the major limitations of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Donor natural killer cells (NK) cytokines have good potential in GVHD prevention reconstitution enhancement. Improved survival after allo-HSCT therefore requires effective prophylaxis to reduce strategy mediate graft-versus-leukemia (GVL) effect. We studied administration expanded donor NK infusion interleukin-2 (IL-2) IL-15...
Highlights•This study demonstrates that KIR2DS4 and its variant KIR1D are associated with outcomes for patients a donors KIR gene haplotype A in HSCT involving HLA-identical siblings.•KIR2DS4/KIR1D subclassification is helpful donor selection recipients of sibling-related HLA-matched HSCT.AbstractOutcomes hematopoietic stem cell transplantation (HSCT) various recipient killer immunoglobulin-like receptor (KIR) genotypes have been studied extensively. The associations between from not...
Genetic diagnostic methods for evaluation of chimerism after HSCT, such as STR-PCR and XY-FISH, have limited sensitivity. When donor is in the micro range (< 1%), deviations accuracy assessment are most significant disadvantage these common methods. We developed a highly sensitive method that applies SNPs based on NGS order to explore value cell microchimerism microtransplantation (MST). This improved SNP-NGS approach has higher sensitivity (0.01-0.05%) only requires small amount DNA (8-200...
Umbilical cord blood (UCB) is used increasingly as a source of hematopoietic cells because lower risk graft-versus-host disease (GVHD). Myeloablative conditioning before allogeneic umbilical transplant (allo-UCBT) results in thymic epithelial cell injury and T-cell immune deficiency. Full-term fetal were previous murine allo-UCBT model with limited number mice surviving the myeloablative conditioning. We designed viable protocol platelet concentrate support. Keratinocyte growth factor (KGF)...
Posaconazole (PCZ) is used prophylactically to prevent invasive fungal infections (IFIs) in patients with hematological malignancies.To evaluate the cut-off serum concentration of PCZ for successful IFI prophylaxis Chinese subjects.A total 74 treated induction chemotherapy (n = 10) and allogeneic hematopoietic stem cell transplantation (HSCT) 64), who received as an oral suspension >7 days, were included study. Clinical, radiological, microbiological culture results, treatment responses...
The KIR2DS4 variants differ in exon 5 and play a role hematopoietic stem cells transplantation (HSCT). A sequence-based testing (SBT) TOPO TA cloning system identifying distinguishing alleles of the gene was established applied to total 150 Chinese-Han individuals: 75 patients received T-cell-depleted HSCT their unrelated donors. majority (139) samples (92.7%) were positive for KIR2DS4. Four nine known alleles, *00101, *003,*004, *007, identified. In haplotype A/A group, higher risk acute...
Peripheral T cell lymphomas (PTCLs) often carry poor outcomes with conventional chemotherapy, and hematopoietic transplantation (HCT) can benefit patients PTCL. We conducted a retrospective review of 67 PTCL who underwent autologous HCT (autoHCT, n = 43; median age, 40 years) or allogeneic (alloHCT, 24; 36.5 from 2004 to 2016. With follow-up 27 months, 5-year progression-free survival (PFS) overall (OS) autoHCT were 49% 57%, respectively. Among alloHCT recipients, the PFS OS 54% 55%, When...
Recombinant-activated factor VII (rVIIa) is a vitamin K-dependent glycoprotein that an analog of the naturally occurring protease. It has off-label use to control life-threatening bleeding refractory other measures and was shown decrease transfusion requirements. Gastrointestinal (GI) severe complication following hematopoietic stem cell transplantation (HSCT) in patients with thrombocytopenia, while hemostatic based on antifibrinolytic or therapy may not always be successful. The present...
Effective treatments for relapsed Ph+ALL with T315I mutation are few; CD19 CAR T-cell therapy a potential this condition. We reported 7 patients mutation, who were treated pre- or post-allo-HSCT CD19-specific T-cells. Of the cases, 6 in CR CRp within 1 month after first infusion of MRD revealed rapid decline patients. BCR/ABL fusion transcripts negative 4/5 cases (not performed 2). Three maintained remission without evidence by QPCR until final follow-up, which 2 received anti-CD19 T-cells...