A5072777068- Genetic Associations and Epidemiology
- Neurological disorders and treatments
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Advanced Proteomics Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Metabolomics and Mass Spectrometry Studies
- Geochemistry and Geologic Mapping
- Genetic Mapping and Diversity in Plants and Animals
- Oral microbiology and periodontitis research
- Cardiovascular Disease and Adiposity
- Circadian rhythm and melatonin
- Pancreatic and Hepatic Oncology Research
- Genetic and phenotypic traits in livestock
- Immune Cell Function and Interaction
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Parkinson's Disease Mechanisms and Treatments
- Inflammatory Bowel Disease
- Gut microbiota and health
- Chronic Kidney Disease and Diabetes
- Race, Genetics, and Society
- Bayesian Modeling and Causal Inference
- Appendicitis Diagnosis and Management
- Craniofacial Disorders and Treatments
Capital Normal University
2021-2025
Stanford University
2017-2024
University of Science and Technology of China
2023-2024
Huadong Hospital
2024
Fudan University
2024
VA Palo Alto Health Care System
2019
Peking University
2014-2018
Yale University
2017
Anhui Provincial Hospital
2016
Anhui Medical University
2015
Abstract Motivation: Direct analysis of microbial communities in the environment and human body has become more convenient reliable owing to advancements high-throughput sequencing techniques for 16S rRNA gene profiling. Inferring correlation relationship among members is fundamental importance genomic survey study. Traditional Pearson treating observed data as absolute abundances microbes may lead spurious results because only represent relative abundances. Special care appropriate methods...
Understanding of the RNA editing process has been broadened considerably by next generation sequencing technology; however, several issues regarding this regulatory step remain unresolved – strategies to accurately delineate editome, mechanism which its profile is maintained, and evolutionary functional relevance. Here we report an accurate quantitative editome for rhesus macaque, a close relative human. By combining genome transcriptome multiple tissues from same animal, identified 31,250...
Patients with ulcerative colitis (UC) have low response rates to anti-integrin medications, necessitating the identification of noninvasive biomarkers for predicting remission therapy. In this study, patients moderate severe UC commencing therapy (n = 29), inactive mild 13), and healthy controls 11) were selected. Besides clinical evaluation, fecal samples collected at baseline week 14 from patients. The was defined based on Mayo score. Fecal assessed 16S rRNA gene sequencing, liquid...
Summary Marine Group II archaea are widely distributed in global oceans and dominate the total archaeal community within upper euphotic zone of temperate waters. However, factors controlling distribution MGII poorly delineated physiology ecological functions these still‐uncultured organisms remain elusive. In this study, we investigated planktonic associated with particles free‐living forms Pearl River Estuary (PRE) over a 10‐month period. We detected high abundance particle‐associated PRE...
The increasing quality and the reducing cost of high-throughput sequencing technologies for 16S rRNA gene profiling enable researchers to directly analyze microbe communities in natural environments. direct interactions among microbial species a given ecological system can help us understand principles community assembly maintenance under various conditions. Compositionality dimensionality microbiome data are two main challenges inferring interaction network microbes. In this article, we use...
Background: Approximately 13% of black individuals carry 2 copies the apolipoprotein L1 ( APOL1 ) risk alleles G1 or G2, which are associated with 1.5- to 2.5-fold increased chronic kidney disease. There have been conflicting reports as whether an association exists between and cardiovascular disease (CVD) that is independent effects on We sought test G1/G2 coronary artery disease, peripheral stroke among in Million Veteran Program. Methods: performed a time-to-event analysis retrospective...
Abstract We report a systematic quantification of 10,841 unique proteins from over 700 GTEx samples, representing five human tissues. Sex, age and genetic factors are associated with variation in protein abundance. In total, 1981 cis-protein quantitative trait loci (cis-pQTL) identified, which majority targets have not been assayed the recent plasma-based proteogenomic studies. Integrating transcriptomic information matching tissues delineates concordant as well discordant expression...
Deep Brain Stimulation (DBS) is a critical intervention for various neurological disorders. While effective, the traditional local infiltration anesthesia used in DBS surgeries often hinders electrophysiological recording quality and patient cooperativeness. The research aims to evaluate impact of versus scalp block anesthetic methods on signal cooperativeness during surgeries. This study involved patients who participated an intraoperative task bilateral subthalamic nucleus surgery...
Abstract Determining protein levels in each tissue and how they compare with RNA is important for understanding human biology disease as well regulatory processes that control levels. We quantified the relative from 12,627 genes across 32 normal types prepared by GTEx project. Known new specific or enriched proteins (5,499) were identified compared to transcriptome data. Many ubiquitous transcripts are found encode highly proteins. Discordance sites of expression detection also revealed...
Abstract Motivation The composition and structure of microbial communities on the body surface are closely related to human health. interaction relationship among microbes can help us understand formation microecological environment biological mechanism by which microorganisms influence host With high-throughput sequencing technologies, abundances in a natural be directly measured without isolation culture. Sequencing experiments microbiome studies measure relative abundance microbes, is...
Programmed cell death 1 (PD-1) inhibitors are immune checkpoint (ICI) that have demonstrated significant efficacy in treating various advanced malignant tumors. While most patients tolerate treatment well, several adverse drug reactions, such as fatigue, myelosuppression, and ICI-associated colitis, been reported.
Abstract Advances in multiplex mass spectrometry-based technologies have enabled high-throughput, quantitative proteome profiling of large cohort. However, certain experimental design configurations can amplify sample variability and introduce systematic biases. To address these challenges, we incorporated two novel features a recent proteogenomic investigation: (1) the inclusion reference samples within each spectrometry run to serve as internal standards, (2) analysis specimen technical...
Background: Previous studies suggest that the X-ray repair cross-complementing group 3 gene (XRCC3) Thr241Met genetic variant could be potentially associated with risk of prostate cancer. However, results from these published were conflicting rather than conclusive.Objectives:This meta-analysis aimed to conduct a better understanding effects XRCC3 on cancer risk.Methods: We identified three eligible studies, 499 cases and 571 controls.Results: Overall, significant associations detected in...
Motivation: Epistatic miniarrary profile (EMAP) studies have enabled the mapping of large-scale genetic interaction networks and generated large amounts data in model organisms. It provides an incredible set molecular tools advanced technologies that should be efficiently understanding relationship between genotypes phenotypes individuals. However, network information gained from EMAP cannot fully exploited using traditional statistical models. Because is always heterogeneous, for example,...
Abstract Coronary artery disease (CAD) is a leading cause of death, yet its genetic determinants are not fully elucidated. We report multi-ethnic genome-wide association study CAD involving nearly quarter million cases, incorporating the largest cohorts to date Whites, Blacks, and Hispanics from Million Veteran Program with existing studies including CARDIoGRAMplusC4D, UK Biobank, Biobank Japan. verify substantial equivalent heritability across multiple ancestral groups, discover 107 novel...