Christopher Brown

ORCID: 0000-0003-1405-0001
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About
Contact & Profiles
Research Areas
  • Chromosomal and Genetic Variations
  • Tissue Engineering and Regenerative Medicine
  • Modular Robots and Swarm Intelligence
  • Athletic Training and Education
  • Inclusion and Disability in Education and Sport
  • Shoulder Injury and Treatment
  • Genetic Associations and Epidemiology
  • Entrepreneurship Studies and Influences
  • Transboundary Water Resource Management
  • Archaeology and Natural History
  • Muscle activation and electromyography studies
  • Cervical Cancer and HPV Research
  • Tendon Structure and Treatment
  • Healthcare innovation and challenges
  • Youth Development and Social Support
  • Alzheimer's disease research and treatments
  • Abdominal Trauma and Injuries
  • Functional Brain Connectivity Studies
  • Advanced MRI Techniques and Applications
  • Neuroscience and Neuropharmacology Research
  • Infections and bacterial resistance
  • Antifungal resistance and susceptibility
  • Neuroscience and Neural Engineering
  • Family Business Performance and Succession
  • Housing, Finance, and Neoliberalism

University of Pennsylvania
2017-2024

University of Florida
2017-2024

Morriston Hospital
2024

New Mexico State University
2001-2023

University of Southern Mississippi
2014-2022

Thermo Fisher Scientific (Sweden)
2020

Office of Technology Transfer
2020

University of Bristol
2013-2017

Chonnam National University Hospital
2013-2017

North Dakota State University
2016

François Aguet Shankara Anand Kristin Ardlie Stacey Gabriel Gad Getz and 95 more Aaron Graubert Kane Hadley Robert E. Handsaker Katherine Huang Seva Kashin Xiao Li Daniel G. MacArthur Samuel R. Meier Jared L. Nedzel Duyen T. Nguyen Ayellet V. Segrè Ellen Todres Brunilda Balliu Alvaro Barbeira Alexis Battle Rodrigo Bonazzola Andrew Brown Christopher Brown Stephane E. Castel Donald F. Conrad Daniel J. Cotter Nancy J. Cox Sayantan Das Olivia M. de Goede Emmanouil T. Dermitzakis Jonah Einson Barbara E. Engelhardt Eleazar Eskin Tiffany Eulalio Nicole M. Ferraro Elise D. Flynn Laure Frésard Eric R. Gamazon Diego Garrido-Martín Nicole R. Gay Michael J. Gloudemans Roderic Guigó Andrew R. Hame Yuan He Paul Hoffman Farhad Hormozdiari Lei Hou Hae Kyung Im Brian Jo Silva Kasela Manolis Kellis Sarah Kim-Hellmuth Alan Kwong Tuuli Lappalainen Xin Li Yanyu Liang Serghei Mangul Pejman Mohammadi Stephen B. Montgomery Manuel Muñoz-Aguirre Daniel Nachun Andrew B. Nobel Meritxell Oliva YoSon Park Yongjin Park Princy Parsana Abhiram Rao Ferrán Reverter John M. Rouhana Chiara Sabatti Ashis Saha Matthew Stephens Barbara E. Stranger Benjamin J. Strober Nicole A. Teran Ana Viñuela Gao Wang Xiaoquan Wen Fred A. Wright Valentin Wucher Yuxin Zou Pedro G. Ferreira Gen Li Marta Melé Esti Yeger‐Lotem Mary E. Barcus Debra Bradbury Tanya Krubit Jeffrey A. McLean Liqun Qi Karna Robinson Nancy Roche Anna Marie Smith Leslie H. Sobin David E. Tabor Anita H. Undale Jason Bridge Lori E. Brigham Barbara A. Foster Bryan M. Gillard

The Genotype-Tissue Expression (GTEx) project dissects how genetic variation affects gene expression and splicing.

10.1126/science.aaz1776 article EN public-domain Science 2020-09-10
Alvaro Barbeira Scott Dickinson Rodrigo Bonazzola Jiamao Zheng Heather E. Wheeler and 95 more Jason Torres Eric S. Torstenson Kaanan P. Shah Tzintzuni Garcia Todd L. Edwards Eli A. Stahl Laura M. Huckins François Aguet Kristin Ardlie Beryl B. Cummings Ellen Gelfand Gad Getz Kane Hadley Robert E. Handsaker Katherine Huang Seva Kashin Konrad J. Karczewski Monkol Lek Xiao Li Daniel G. MacArthur Jared L. Nedzel Duyen T. Nguyen Michael S. Noble Ayellet V. Segrè Casandra A. Trowbridge Taru Tukiainen Nathan S. Abell Brunilda Balliu Ruth Barshir Omer Basha Alexis Battle Gireesh K. Bogu Andrew Brown Christopher Brown Stephane E. Castel Lin Chen Colby Chiang Donald F. Conrad Farhan N. Damani Joe R. Davis Olivier Delaneau Emmanouil T. Dermitzakis Barbara E. Engelhardt Eleazar Eskin Pedro G. Ferreira Laure Frésard Eric R. Gamazon Diego Garrido-Martín Ariel DH Gewirtz Genna Gliner Michael J. Gloudemans Roderic Guigó Ira M. Hall Buhm Han Yuan He Farhad Hormozdiari Cédric Howald Brian Jo Eun Yong Kang Yungil Kim Sarah Kim-Hellmuth Tuuli Lappalainen Gen Li Xin Li Boxiang Liu Serghei Mangul Mark I. McCarthy Ian C. McDowell Pejman Mohammadi Jean Monlong Stephen B. Montgomery Manuel Muñoz-Aguirre Anne W. Ndungu Andrew B. Nobel Meritxell Oliva Halit Ongen John Palowitch Nikolaos Panousis Panagiotis Papasaikas YoSon Park Princy Parsana A. J. Payne Christine B. Peterson Jie Quan Ferrán Reverter Chiara Sabatti Ashis Saha Michael Sammeth Alexandra J. Scott Andrey A. Shabalin Reza Sodaei Matthew Stephens Barbara E. Stranger Benjamin J. Strober Jae Hoon Sul

Abstract Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy general robustness misspecified reference sets. We apply this framework 44 GTEx tissues 100+ from GWAS meta-analysis studies, creating growing public catalog of associations seeks capture the effects variation on human...

10.1038/s41467-018-03621-1 article EN cc-by Nature Communications 2018-05-02
Kathryn Demanelis Farzana Jasmine Lin Chen Meytal Chernoff Tong Lin and 95 more Dayana Delgado Chenan Zhang Justin Shinkle Mekala Sabarinathan Hannah Lin Eduardo Ramirez Meritxell Oliva Sarah Kim-Hellmuth Barbara E. Stranger Tsung‐Po Lai Abraham Aviv Kristin Ardlie François Aguet Habibul Ahsan Jennifer A. Doherty Muhammad G. Kibriya Brandon L. Pierce François Aguet Shankara Anand Kristin Ardlie Stacey Gabriel Gad Getz Aaron Graubert Kane Hadley Robert E. Handsaker Katherine Huang Seva Kashin Xiao Li Daniel G. MacArthur Samuel R. Meier Jared L. Nedzel Duyen T. Nguyen Ayellet V. Segrè Ellen Todres Brunilda Balliu Alvaro Barbeira Alexis Battle Rodrigo Bonazzola Andrew Brown Christopher Brown Stephane E. Castel Donald F. Conrad Daniel J. Cotter Nancy J. Cox Sayantan Das Olivia M. de Goede Emmanouil T. Dermitzakis Jonah Einson Barbara E. Engelhardt Eleazar Eskin Tiffany Eulalio Nicole M. Ferraro Elise D. Flynn Laure Frésard Eric R. Gamazon Diego Garrido-Martín Nicole R. Gay Michael J. Gloudemans Roderic Guigó Andrew R. Hame Yuan He Paul Hoffman Farhad Hormozdiari Lei Hou Hae Kyung Im Brian Jo Silva Kasela Manolis Kellis Sarah Kim-Hellmuth Alan Kwong Tuuli Lappalainen Xin Li Yanyu Liang Serghei Mangul Pejman Mohammadi Stephen B. Montgomery Manuel Muñoz-Aguirre Daniel Nachun Andrew B. Nobel Meritxell Oliva YoSon Park Yongjin Park Princy Parsana Abhiram Rao Ferrán Reverter John M. Rouhana Chiara Sabatti Ashis Saha Matthew Stephens Barbara E. Stranger Benjamin J. Strober Nicole A. Teran Ana Viñuela Gao Wang Xiaoquan Wen

Telomere length within an individual varies in a correlated manner across most tissues.

10.1126/science.aaz6876 article EN Science 2020-09-10

10.1016/j.cell.2020.08.036 article EN publisher-specific-oa Cell 2020-09-10

The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as key molecule in Alzheimer's disease other tauopathies. However, it unknown how that primarily located axons involved believed to have synaptic origin. To investigate possible function tau, we studied plasticity the hippocampus found selective deficit long-term depression (LTD) knockout mice vivo vitro, an effect was replicated by RNAi knockdown vitro. We induction LTD...

10.1098/rstb.2013.0144 article EN cc-by Philosophical Transactions of the Royal Society B Biological Sciences 2013-12-03

10.1016/s0749-8063(97)90222-x article EN Arthroscopy The Journal of Arthroscopic and Related Surgery 1997-02-01

Context Mobile applications (apps) are growing in popularity due to the increased use of smartphones. Many available apps educational nature and may provide both students educators freedom for learning occur outside typical classroom environment. Objective To a description relevant along with brief synopsis suggested by athletic training students. Additional information that affect user's app selection, such as cost, size download, consumer ratings, if available, is also included. Background...

10.4085/1002190 article EN Athletic Training Education Journal 2015-04-01

This study provides a preliminary analysis of the market for PhDs in public affairs and administration projected over next several years. Drawing on data gathered from three surveys, we explore demand academic (survey 1) supply (surveys 2 3). The is further refined to estimate nonacademic employment 3 examination job postings). We also diversity PhD graduates. kind largely missing literature therefore an important, albeit initial contribution. found that gap exists between production them by...

10.1080/15236803.2015.12001820 article EN Journal of Public Affairs Education 2015-03-01

Context: The cohort athletic training curriculum features a competency-based approach that allows the student to matriculate through program in systematic fashion. This method is desired as it for efficient delivery and mastery of educational content associated clinical skills. result may be an inflexible can unforgiving when unforeseen circumstances arise. Objective: To introduce unique curricular design undergraduate setting more flexible than traditional model. Background: Athletic...

10.4085/070260 article EN Athletic Training Education Journal 2012-04-01

Clinical Scenario: Iontophoresis is a method of local transfer ionized medicated and nonmedicated substances through the skin into target tissues using magnetic polarization. The anti-inflammatory properties exhibited by dexamethasone sodium phosphate (DEX) combined with iontophoresis make it potentially desirable treatment for clinicians wishing to administer noninvasive localized drug concentration without having large systemic that drug. Since concurrent treatments are commonly used in...

10.1123/jsr.2014-0172 article EN Journal of Sport Rehabilitation 2014-09-08

Clinical Scenario: Orthopedic knee conditions are regularly treated in sports-medicine clinics. Rehabilitation protocols for these often designed to address the associated quadriceps strength deficits. Despite efforts, patients with orthopedic fail completely regain their strength. Disinhibitory modalities have recently been suggested as a clinical tool that can be used counteract negative effects of arthrogenic muscle inhibition, which is believed limit effectiveness therapeutic exercise....

10.1123/jsr.2015-0100 article EN Journal of Sport Rehabilitation 2016-11-11

Focused Clinical Question : Do soft-shell helmet covers reduce head impact severity in American football helmets? Bottom Line There is consistent SORT level C evidence to support that measures of and linear rotational acceleration. The reductions occurred at magnitudes less than the average reported concussive impact, which limits application with respect concussion incidence or risk among players.

10.1123/ijatt.2022-0134 article EN International Journal of Athletic Therapy & Training 2023-04-27

Dans l'ère post-Nafta, le Canada, Mexique et les États-Unis font face à un problème de gestion l'eau. Ces défis, incluant la demande croissante l'eau problèmes des écosystèmes, tentent : balancer demandes États riverains en amont aval, faire l'extraction eaux souterraines potentielle découverte d'aquifères partagés (surtout dans endroits où il n'y a qu'une seule source aquifère) finalement aux persistants qualité Nous couvrirons cet article une vue d'ensemble mentionnés ci-haut, contexte...

10.4000/vertigo.9721 article FR cc-by-nc-nd VertigO 2010-06-10

AbstractThe onset of the 21st century sees U.S.-Mexico border facing numerous challenges in meeting demand for water resources across a diverse set interests, while also protecting quality and providing in-stream uses. This chapter surveys ongoing resource management efforts region examines broad transboundary literature to identify existing innovations note offer ideas future research. The increasing role public participation democratic decision policy making process, watershed-based...

10.1016/s0362-3319(03)00068-5 article EN The Social Science Journal 2003-10-14

Abstract Almost any issue facing the U.S.-Mexican border region is intertwined with actual itself-the political barrier between two countries that sharply divides priorities, socioeconomics, culture, language, and governmental oversight. While pollution, water shortages, disease know no borders, means to address such problems are often constrained by them.

10.1080/00139150409603196 article EN Environment Science and Policy for Sustainable Development 2004-01-01

Abstract Background Frontotemporal lobar degeneration (FTLD) is defined neuropathologically by misfolded tau (FTLD‐tau) or TAR DNA‐binding protein of 43 kDa (FTLD‐TDP). However, we lack biomarkers that can distinguish them in vivo which a major barrier to effective disease‐modifying treatment trials. Based on neuropathological evidence distinct patterns cellular degeneration, more prominent white matter (WM) for FTLD‐tau relative FTLD‐TDP, hypothesized diffusion MRI (dMRI) measures...

10.1002/alz.092085 article EN cc-by Alzheimer s & Dementia 2024-12-01

Abstract Background Frontotemporal lobar degeneration (FTLD) is defined neuropathologically by misfolded tau (FTLD‐tau) or TAR DNA‐binding protein of 43 kDa (FTLD‐TDP). However, we lack biomarkers that can distinguish them in vivo which a major barrier to effective disease‐modifying treatment trials. Based on neuropathological evidence distinct patterns cellular degeneration, more prominent white matter (WM) for FTLD‐tau relative FTLD‐TDP, hypothesized diffusion MRI (dMRI) measures...

10.1002/alz.094023 article EN cc-by Alzheimer s & Dementia 2024-12-01

There are many hindrances to consumer participation in the planning and management of disability services. Consumer perspectives, preferences felt-needs not always taken into account by those providing necessary As one important group involved social care, workers committed extend process where needs perspectives incorporated The Commonwealth Government's emphasis on services, as expressed Disability Services Act, 1986, is therefore interest them seeing ideals realised services which...

10.1080/03124078908550065 article EN Australian Social Work 1989-12-01
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