A5042339063- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Arsenic contamination and mitigation
- Genetic Associations and Epidemiology
- Infant Nutrition and Health
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Genetics, Aging, and Longevity in Model Organisms
- Single-cell and spatial transcriptomics
- Telomeres, Telomerase, and Senescence
- Child Nutrition and Water Access
- Race, Genetics, and Society
- Enterobacteriaceae and Cronobacter Research
- Milk Quality and Mastitis in Dairy Cows
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Folate and B Vitamins Research
- Advanced biosensing and bioanalysis techniques
- Genetic Syndromes and Imprinting
- Immune responses and vaccinations
- RNA regulation and disease
- Hemoglobinopathies and Related Disorders
- Gene expression and cancer classification
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of Chicago
2017-2024
Chicago Department of Public Health
2017-2024
Washington University in St. Louis
2013-2015
Telomere length within an individual varies in a correlated manner across most tissues.
ABSTRACT Telomere shortening is a hallmark of aging. length (TL) in blood cells has been studied extensively as biomarker human aging and disease; however, little known regarding variability TL non-blood, disease-relevant tissue types. Here we characterize measurements for 6,391 samples, representing >20 types 952 individuals from the Genotype-Tissue Expression (GTEx) Project. We describe differences across types, positive correlation among associations with age ancestry. show that...
<p>Supplementary Figure S2 shows a Principal Component Analysis of DNA methylation in the benign and tumor tissue African American European individuals, demonstrating type as largest source variation (A&B). Additionally, it that within samples PC1 is associated with Gleason Score (C).</p>
<div>AbstractBackground:<p>African American (AA) men are at increased risk of prostate cancer compared with European (EA) men. Biological mechanisms, including epigenetics, likely contribute to this disparity, but prior studies have been limited by sample size, candidate gene approaches, or lack epigenome-wide DNA methylation (DNAm) data.</p>Methods:<p>To improve our understanding these we DNAm features distinguishing tumor and paired histologically benign tissue from...
<p>Supplementary Figure S8 shows the performance of African American and European multi-CpG scores in an external validation set from TCGA.</p>
<p>Supplementary Figure S6 shows the distribution of differentially methylated CpGs across genome in African Americans and European compared with overall probe tested EPIC array CpGs.</p>
<p>Supplementary Figure S7 shows the performance of ancestry-specific multi-CpG scores (using 10 CpGs) in predicting tumor vs benign tissue African American and European men.</p>
<p>Supplementary Figure S4 shows the distribution of post-QC CpGs across EPIC Infinium I and II assays, chromosomes, genomic regions including CpG islands transcription start sites.</p>
<p>Supplementary Figure S3 shows a Principal Component Analysis of DNA methylation in tumor tissue African Americans and European demonstrates an association between PC1 Gleason Score.</p>
<p>Supplementary Figure S1 shows the results of a Principal Component Analysis participant SNP genotypes, demonstrating separate clusters those with African American and European ancestry.</p>
<p>Supplementary Figure S9 shows the similar relationship between tumor and benign tissue in African American European men as well presence of ancestry-associated CpGs both tissue.</p>
<p>Supplementary Figure S5 shows a dendogram demonstrating the initial clustering analysis based on all post-QC probes in which there is sample by tissue type.</p>