A5032118340- CRISPR and Genetic Engineering
- Advanced Antenna and Metasurface Technologies
- Electromagnetic wave absorption materials
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Metamaterials and Metasurfaces Applications
- Molecular Biology Techniques and Applications
- Bioinformatics and Genomic Networks
- Venous Thromboembolism Diagnosis and Management
- Colorectal Cancer Treatments and Studies
- Genetic Associations and Epidemiology
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Liver Disease and Transplantation
- Viral Infections and Immunology Research
- Vascular Malformations and Hemangiomas
- Single-cell and spatial transcriptomics
- RNA Interference and Gene Delivery
- Vascular Malformations Diagnosis and Treatment
Soochow University
2015-2025
Walter and Eliza Hall Institute of Medical Research
2024-2025
Anshun University
2025
Peking University
2011-2025
Peking University People's Hospital
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Ocean University of China
2025
Taishan Medical University
2025
Shandong First Medical University
2024-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2024
Many complex human phenotypes exhibit sex-differentiated characteristics. However, the molecular mechanisms underlying these differences remain largely unknown. We generated a catalog of sex in gene expression and genetic regulation across 44 tissue sources surveyed by Genotype-Tissue Expression project (GTEx, v8 release). demonstrate that influences levels cellular composition samples body. A total 37% all genes sex-biased at least one tissue. identify cis quantitative trait loci (eQTLs)...
Cell type composition, estimated from bulk tissue, maps the cellular specificity of genetic variants.
Telomere length within an individual varies in a correlated manner across most tissues.
Two-dimensional materials, especially the newly emerging MXene, have attracted numerous interests in fields of energy conversion/storage and electromagnetic shielding/absorption. However, inherently inevitable aggregation absence magnetic loss MXene considerably limit its absorption application. The introduction component favorable structural engineering are alternatives to improve microwave (MA) performance. Herein, we report a spheroidization strategy assemble double-shell MXene@Ni...
Abstract A novel strategy is used to design large‐scale polarized carbon‐based dielectric composites with sufficient interaction electromagnetic waves. Highly uniform polar zinc oxide arrays are vertically grown on a flexible conductive carbon cloth substrate (CC@ZnO) via an in situ orientation growth process. Anion regulation found be key factor the morphology of hierarchical ZnO including single‐rod, cluster and tetrapod‐shaped. As typical loss hybrid composite, parameters CC@ZnO system...
The nonlocal Allen--Cahn equation, a generalization of the classic equation by replacing Laplacian with parameterized diffusion operator, satisfies maximum principle as its local counterpart. In this paper, we develop and analyze first second order exponential time differencing schemes for solving which preserve discrete unconditionally. fully numerical are obtained applying stabilized approximations integration quadrature-based finite difference discretization in space. We derive their...
Cabbage-like ZnCo<sub>2</sub>O<sub>4</sub> with abundant flakes possess a maximum RL value of −36.33 dB and the effective bandwidth 5.11 GHz.
Technological advances in rare DNA mutations detection have revolutionized the diagnosis and monitoring of tumors, but they are still limited by lack supersensitive high-coverage procedures for identifying low-abundance mutations. Here, we describe a single-tube, multiplex PCR-based system, A-Star, that involves hyperthermophilic Argonaute from Pyrococcus furiosus (PfAgo) highly efficient beneficial its compatibility with polymerase. This novel technique uses specific guide design strategy...
ABSTRACT The cytochrome P450 sterol 14α-demethylase enzyme (CYP51) is the target of azole antifungals. Azoles block ergosterol synthesis, and thereby fungal growth, by binding in active-site cavity ligating iron atom heme cofactor through a nitrogen azole. Mutations around CYP51 active site have resulted resistance. In this work, homology models enzymes from Aspergillus fumigatus Candida albicans were constructed based on X-ray crystal structure Mycobacterium tuberculosis . Using these...
Outliers in the human transcriptome reveal functional effects of rare genetic variants.
As a typical 2D (two dimensional) material, Ti3C2Tx, has been used as promising microwave absorber (MA) because of its massive interface architecture, abundant natural defects, and chemical surface functional groups. However, single dielectric-type loss excessive high conductivity seriously restrict the further enhancement MA performance. Herein, we first describe simple spray-drying routine to reshape MXene into confined magnetized microsphere with tightly embedded Fe3O4 nanospheres...
Abstract Three‐dimensional (3D) materials assembled by 2D layered lamella can provide abundant interfaces which are greatly advantageous for high‐performance microwave absorbers. Herein, accordion‐like CeO 2− x /reduced graphene oxide (CeO /RGO) hybrid be successfully synthesized a solvothermal and hydrothermal method, composed of laminated RGO sheets confined nanoparticles (NPs). The multilayer structure is attributed to the process Ce‐MOF dissolving into NPs, then NPs combining with (GO)...
Purpose To determine whether posttransjugular intrahepatic portosystemic shunt (TIPS) placement anticoagulation therapy could benefit patients with cirrhosis and portal vein thrombosis (PVT) from the perspective of a change in patency status clinical outcomes. Materials Methods The study was approved by institutional review board, informed consent obtained each patient. From October 2012 to February 2014, PVT who underwent TIPS were randomly assigned or control group. All followed at 1, 3,...
The introduction of a cellular structure in conductive polymer composites is supposed to be an effective way ameliorate the electromagnetic interference (EMI) shielding properties.
Recently, it is still a great challenge to develop new type of absorber that possesses special advantages low cost, ultrawide bandwidth, and strong absorption intensity. Herein, the unique "Matryoshka doll"-like CeO2 microspheres with tunable interspaces were successfully synthesized by facile template-free method. The as-synthesized hierarchical yolk–shell constructed layer outer shell multiple inner cores. interspace gap can be simply adjusted only altering solvothermal reaction time....
Despite all the advances in multimodal imaging, it remains a significant challenge to acquire both magnetic resonance and nuclear imaging single dose because of enormous difference sensitivity. Indeed, is almost 106-fold more sensitive than (MRI); thus, repeated injections are generally required obtain sufficient MR signals after imaging. Here, we show that strategically engineered magnetoferritin nanoprobes can image tumors with high sensitivity specificity using SPECT MRI living mice...
An HDR-based Cas9/RecA system was developed to precisely correct the Pde6b mutation in rods of rd1 mice restore their vision.
CRISPR-Cas12a (Cpf1) is widely used for pathogen detection. However, most Cas12a nucleic acid detection methods are limited by a PAM sequence requirement. Moreover, preamplification and cleavage separate. Here, we developed one-step RPA-CRISPR (ORCD) system unrestricted the with high sensitivity specificity that offers one-tube, rapid, visually observable of acids. In this system, RPA amplification performed simultaneously, without separate product transfer steps, 0.2 copies/μL DNA 0.4 RNA...