Leilei Cheng

ORCID: 0000-0003-0677-7892
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About
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Research Areas
  • Cardiovascular Function and Risk Factors
  • Cardiac Imaging and Diagnostics
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Cardiac Valve Diseases and Treatments
  • Pulmonary Hypertension Research and Treatments
  • Congenital Heart Disease Studies
  • Infective Endocarditis Diagnosis and Management
  • Cardiomyopathy and Myosin Studies
  • Cancer Treatment and Pharmacology
  • Cardiovascular Disease and Adiposity
  • Cardiac Fibrosis and Remodeling
  • Health and Medical Research Impacts
  • Economic and Environmental Valuation
  • Land Use and Ecosystem Services
  • Viral Infections and Immunology Research
  • Cancer Immunotherapy and Biomarkers
  • Ultrasound and Hyperthermia Applications
  • Tissue Engineering and Regenerative Medicine
  • Cardiac Arrhythmias and Treatments
  • Aortic Disease and Treatment Approaches
  • Conservation, Biodiversity, and Resource Management
  • Biomedical and Engineering Education
  • Cardiac pacing and defibrillation studies
  • Peptidase Inhibition and Analysis
  • Medical Imaging Techniques and Applications

Hefei University of Technology
2025

Fudan University
2015-2024

Shanghai Institute of Hematology
2013-2024

Zhongshan Hospital
2015-2024

The First Affiliated Hospital, Sun Yat-sen University
2005-2024

Sun Yat-sen University
2005-2024

John H. Stroger, Jr. Hospital of Cook County
2024

National Clinical Research Center for Digestive Diseases
2024

Institute of Desertification Studies
2014-2023

Chinese Academy of Forestry
2014-2023

Background The reference values and impact of physiologic variables on echocardiographic quantification left ventricular (LV) longitudinal circumferential layer‐specific myocardial strains in large series healthy persons remain unknown. This study prospectively investigated the age, gender, other parameters LV strains. Methods 119 volunteers (age range, 22–76; 50% women) underwent echocardiography. Short‐axis (for strain) apical views were analyzed using modified speckle tracking software...

10.1111/echo.13132 article EN Echocardiography 2015-12-12

The purpose of this study was to assess the associations between 3-dimensional echocardiography (3DE)-derived changes in right ventricular (RV) volumes and strains with subsequent RV cardiotoxicity patients treated anthracyclines.Although early detection prediction left (LV) dysfunction has been widely studied receiving anthracyclines, little is known about size function population.A total 74 diffuse large B-cell lymphoma who received 6 cycles anthracycline-based treatment were enrolled....

10.1016/j.jaccao.2020.01.007 article EN cc-by-nc-nd JACC CardioOncology 2020-03-01

Background: Immune checkpoint inhibitor (ICI)-associated myocarditis is an uncommon and potentially fatal immune-related adverse event (irAE). Although corticosteroids are recommended as the first-line treatment by current guidelines, patients still have variable responses to it, guidelines vary significantly in terms of strategies. Objectives: In this study, we performed a retrospective analysis ICI-associated our hospital propose new comparative aid individualized treatment. Methods: We...

10.3389/fphar.2021.770631 article EN cc-by Frontiers in Pharmacology 2021-12-06

Maintaining the integrity and stability of oasis ecosystems is an important topic in field ecological research. Assessment ecosystem services their changes can provide support for sustainable development oases. This study took Dunhuang hyper-arid area as research object used 1990, 2010, 2020 Landsat series satellite images to complete land use interpretation by random forest classification. Then we estimated value (ESV) using benefit transfer method, predicted trend service under three...

10.3390/rs15030564 article EN cc-by Remote Sensing 2023-01-17

Immune checkpoint inhibitors (ICIs)-related myocarditis is now one of the most critical immune-related adverse effects (irAEs) in tumor immunotherapy, which has raised great concern cardio-oncology. The pathogenesis involved cardiac injury remains elusive. Crocin, main component saffron, shown distinct functions cardioprotective and anti-inflammation properties. We therefore aimed to investigate potential effect crocin on protection ICIs-related its underlying molecular mechanism.We...

10.2147/jir.s348464 article EN cc-by-nc Journal of Inflammation Research 2022-03-01

Dysregulated amino acid increases the risk for heart failure (HF) via unclear mechanisms. Here, we find that increased plasma tyrosine and phenylalanine levels are associated with HF. Increasing or by high-tyrosine high-phenylalanine chow feeding exacerbates HF phenotypes in transverse aortic constriction isoproterenol infusion mice models. Knocking down dehydrogenase abolishes effect of phenylalanine, indicating functions converting to tyrosine. Mechanistically, tyrosyl-tRNA synthetase...

10.1016/j.celrep.2023.112400 article EN cc-by Cell Reports 2023-04-01

Abstract Aims To assess the different imaging characteristics between corticosteroid‐sensitive (CS) and corticosteroid‐refractory (CR) immune checkpoint inhibitor‐associated myocarditis (ICIaM) with cardiac magnetic resonance (CMR) potential CMR parameters in early detection of CR ICIaM. Methods results Thirty‐five patients diagnosed ICIaM 30 age gender‐matched cancer without a history ICI treatment were enrolled. contrast was performed within 2 days clinical suspicion. Left ventricular...

10.1002/ehf2.14664 article EN cc-by-nc-nd ESC Heart Failure 2024-01-19

This study selected green spaces from three residential areas in Hefei as the research subjects, combining behavioral observation methods and a natural experiment to collect data 2010 2024. The were then compared using Poisson regression models. Additionally, home visits conducted gather residents’ perceptions of factors contributing decline vitality. Based on survey data, multilevel analysis was performed explore RQGS usage vitality its influencing context rapid urbanization. found...

10.3390/buildings15050788 article EN cc-by Buildings 2025-02-27

AimsRecombinant human neuregulin-1 (rhNRG-1) improves cardiac function in experimental heart failure models, but the underlying mechanism remains largely unknown. In this study, we evaluated whether rhNRG-1 could improve via myosin light chain kinase/myosin 2 ventricular (cMLCK/MLC-2v) pathway rats with myocardial infarction (MI).

10.1093/cvr/cvq223 article EN Cardiovascular Research 2010-07-08

Background: To examine the subclinical myocardial injury shortly after epirubicin exposure in asymptomatic patients with large B-cell non-Hodgkin lymphoma using 2-dimensional (2D)speckle tracking echocardiography. Methods: Sixty-seven aged 52.58 ± 13.86 years treated were studied. Echocardiography was performed at baseline and 1 day completion of therapy. Global regional longitudinal (LS), circumferential (CS) radial strain (RS), standard deviation time to peak LS (TLS-SD), CS (TCS-SD),...

10.5603/cj.2013.0158 article EN Cardiology Journal 2013-12-11

Urban households account for most of the milk consumption in China, but their is hampered by safety concerns. Using survey data collected Beijing and Harbin 2010, this paper simultaneously analyses urban households' using a multiple linear model willingness‐to‐pay an ordered choice model. The results study show that as income increases, consume more are willing to pay higher premium safety. Modern food marketing channels play positive role stimulating building consumers' confidence growth...

10.1111/1467-8489.12065 article EN Australian Journal of Agricultural and Resource Economics 2014-06-03

Pulmonary arterial pressure is an important index in cardiovascular disorders, especially for pulmonary hypertension ( PH ). Doppler echocardiography DE ) widely used as a noninvasive method to assess pressure. However, recent studies have found several hemodynamic factors that affect its accuracy estimating systolic sPAP But the effect of tricuspid regurgitation TR has not been investigated. Therefore, our study aimed determine whether severity will measured by unselected patient...

10.1111/echo.13555 article EN Echocardiography 2017-05-18

Abstract Background Left ventricular global longitudinal strain (LVGLS) has been recommended by current guidelines for diagnosing anthracycline‐induced cardiotoxicity. However, little is known about the early changes in left atrial (LA) morphology and function this population. Our study aimed to evaluate potential usefulness of LA indices their incremental value LVGLS with three‐dimensional echocardiography (3DE) detection subclinical cardiotoxicity patients lymphoma receiving anthracycline....

10.1111/echo.15805 article EN Echocardiography 2024-04-01
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