The dose-dependent toxicity to cardiomyocytes has been well recognized as a central characteristic of doxorubicin (DOX)-induced cardiotoxicity (DIC), however, the pathogenesis DIC in cardiac microenvironment remains elusive. Irisin is new hormone-like myokine released into circulation response exercise with distinct functions regulating apoptosis, inflammation, and oxidative stress. Recent advances revealed role irisin novel therapeutic method an important mediator beneficial effects...

Recent studies have demonstrated that ferroptosis, a novel form of nonapoptotic regulated cell death plays an important role in doxorubicin (DOX)-induced cardiotoxicity (DoIC). Hydrogen sulfide (H

Abstract Clinical therapy of doxorubicin (DOX) is limited due to its cardiotoxicity. miR-146a was proved as a protective factor in many cardiovascular diseases, but role chronic DOX-induced cardiotoxicity unclear. The objective this study demonstrate the low-dose long-term Experiments have shown that DOX intervention caused dose-dependent and time-dependent involving increased apoptosis dysregulation autophagy. inhibited by overexpressed more severe when downgraded. Further research targeted...

Abstract Doxorubicin (DOX)‐induced cardiotoxicity (DoIC) is a major side effect for cancer patients. Recently, ferroptosis, triggered by iron overload, demonstrated to play role in DoIC. How homeostasis dysregulated DoIC remains be elucidated. Here, the authors demonstrate that DOX challenge exhibits reduced contractile function and induction of ferroptosis‐related phenotype cardiomyocytes, evidenced lipid peroxide accumulation, mitochondrial dysfunction. Compared Ferric ammonium citrate...

Mitochondrial dysfunction is a hallmark of heart failure. transplantation has been demonstrated to be able restore function, but its mechanism action remains unresolved. Using an in-house optimized mitochondrial isolation method, we tested efficacy mitochondria in two different failure models. First, using doxorubicin-induced model, demonstrate that before doxorubicin challenge protects cardiac function vivo and prevents myocardial apoptosis, contraction improvement relies on the metabolic...

Abstract Diabetic cardiomyopathy (DbCM) is characterized by diastolic dysfunction, which progresses into heart failure and aberrant electrophysiology in diabetic patients. Dyslipidemia type 2 patients leads to the accumulation of lipid droplets (LDs) cardiomyocytes results toxicity has been suggested drive DbCM. It aimed explore potential pathways that may boost LDs degradation DbCM restore cardiac function. resulted an increase hearts confirmed. Microlipophagy pathway, rather than...

Immune checkpoint inhibitors (ICIs)-related myocarditis is now one of the most critical immune-related adverse effects (irAEs) in tumor immunotherapy, which has raised great concern cardio-oncology. The pathogenesis involved cardiac injury remains elusive. Crocin, main component saffron, shown distinct functions cardioprotective and anti-inflammation properties. We therefore aimed to investigate potential effect crocin on protection ICIs-related its underlying molecular mechanism.We...

Doxorubicin, an anthracycline commonly used for treating cancer patients, is known its cardiotoxic side-effects. Although dose-dependent, but susceptibility remains variable among and childhood-exposure-adult-onset challenging. Besides topoisomerase toxicity, Doxorubicin also toxic to the mitochondria yet underlying late onset mechanism elusive. Here, it observed that mitochondrial copy number in PBMCs of patients treated with chemotherapy negatively correlated change plasma BNP levels after...

The prognostic impact of long-term glycemic variability on clinical outcomes in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) remains unclear. We determined compared hemoglobin A1c (HbA1c) for HF preserved ejection fraction (HFpEF), mid-range (HFmrEF) reduced (HFrEF) a prospective longitudinal study. Patients T2DM, undergone 3 or more HbA1c determinations during the first 18 months, were then followed 42 months. primary outcome was death from any cause. Secondary...

Background Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of patients heart failure. Clinically, HFpEF prevalence shows age and gender biases. Although the majority are elderly, there is an emergence young HFpEF. A better understanding underlying pathogenic mechanism urgently needed. Here, we aimed to determine role aging in pathogenesis Methods Results dietary regimen (high‐fat diet + Nω‐Nitro‐L‐arginine methyl ester hydrochloride) was used induce wild type...

In recent years, the number of cases heart disease has been greatly increasing, and is associated with a high mortality rate. Moreover, development technologies, some advanced types equipment were invented to help patients measure health conditions at home predict risks having disease. The research aims find accuracy self-measurable physical indicators compared all measured by healthcare providers in predicting using five machine learning models. Five models used disease, including Logistics...

A relationship between excess epicardial adipose tissue (EAT) and the risk of atrial fibrillation (AF) has been reported. Browning EAT may be a novel approach for prevention or treatment AF by attenuating fibrosis. Previous studies have identified microRNA-21 (miR-21) as regulatory factor in The present study examined role different subtypes miR-21 browning fibrosis under hyperglycemic conditions. Wild type knockout C57BL/6 mice were used to establish diabetic model via intraperitoneal...

Abstract Background Adipose tissue homeostasis is at the heart of many metabolic syndromes such as diabetes. Previously it has been demonstrated that adipose tissues from diabetic patients are senescent but whether this contributes to cardiomyopathy (DCM) remains be elucidated. Methods The streptozotocin (STZ) type 1 mice were established animal model, and adult mouse ventricular myocytes (AMVMs) isolated by langendorff perfusion well neonatal (NMVMs) used cell models. Senescent associated β...

Both hypertension and hyperuricemia are closely associated with the morbidity mortality of heart failure preserved ejection fraction (HFpEF). However, there is limited evidence on effect uric acid-lowering therapy left ventricular (LV) diastolic function in this population. In randomized study, we prescribed benzbromarone, a drug, to those asymptomatic investigate its clinical benefits by evaluating LV function, incidence HFpEF hospitalization for cardiovascular death.230 participants were...

A higher visit-to-visit variability in low-density lipoprotein cholesterol (LDL-C) is associated with an increased frequency of cardiovascular events. We investigated the association between LDL-C and all-cause mortality, myocardial infarction (MI), coronary revascularization a population non-obstructive artery disease (CAD).From this retrospective cohort individuals who underwent angiography from 2006 to 2010, total 2.012 consecutive patients CAD, three or more determinations during first 2...

Background In patients with both heart failure preserved ejection fraction (HFpEF) and coronary artery disease (CAD), whether adopting an initial invasive strategy benefits better in clinical outcomes compared those who received conservative remains inconclusive. Methods With data from the (HF) cohort study, we analyzed had HFpEF CAD amenable to intervention using propensity score matching of 1:1 ratio compare medical therapy alone. The primary outcome was composite endpoints all-cause...

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Cross-sectional incidence estimation based on recency testing has become a widely used tool in HIV research. Recently, this method gained prominence prevention trials to estimate the "placebo" that participants might experience without preventive treatment. The application of approach faces challenges due non-representative sampling, as individuals aware their HIV-positive status may be less likely participate screening for an trial. To address this, recent phase 3 trial excluded whether...