A5101409076- Diabetes and associated disorders
- Pancreatic function and diabetes
- Virus-based gene therapy research
- Genetic and phenotypic traits in livestock
- Receptor Mechanisms and Signaling
- Genetic Mapping and Diversity in Plants and Animals
- Cardiac Ischemia and Reperfusion
- RNA Interference and Gene Delivery
- Heme Oxygenase-1 and Carbon Monoxide
- Renin-Angiotensin System Studies
- Diabetes Management and Research
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Adipose Tissue and Metabolism
- Natural Antidiabetic Agents Studies
- Cell Image Analysis Techniques
- CAR-T cell therapy research
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Neuroscience and Neuropharmacology Research
- Cardiac Arrest and Resuscitation
- Diet and metabolism studies
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
Third Affiliated Hospital of Southern Medical University
2025
Institute of Botany
2006-2024
Chengdu University of Traditional Chinese Medicine
2024
Shanghai University of Sport
2024
Handan College
2024
Shandong First Medical University
2024
Henan Agricultural University
2024
Guangdong Ocean University
2024
Arizona School of Acupuncture and Oriental Medicine
2016-2023
Shenzhen University
2023
Background— Angiotensin II (Ang II) is a vasoconstrictor but also growth factor. However, the Ang type 1 receptor does not have tyrosine kinase domain that mediates cellular signals for mitosis. We shown acts via “ trans” -activation of epidermal factor (EGFR) to induce activation and mitogen-activated protein kinase/extracellular signal-regulated (ERK) in vascular smooth muscle cells (VSMCs). To examine whether EGFR involved development left ventricular hypertrophy (LVH), we inhibited with...
The development of spontaneous autoimmune diabetes in nonobese diabetic (NOD) mice provides for their use as a model human type 1 diabetes. To test the feasibility muscle-directed gene therapy to prevent diabetes, we developed recombinant adeno-associated virus (rAAV) vectors containing murine cDNAs immunomodulatory cytokines IL-4 or IL-10. Skeletal muscle transduction female NOD with IL-10, but not IL-4, completely abrogated rAAV-IL-10 attenuated production insulin autoantibodies,...
Abstract Background Genome-wide association study (GWAS) is a powerful tool for revealing the genetic basis of quantitative traits. However, studies using GWAS conformation traits cattle comparatively less. This aims to use find candidates genes body Results The Illumina BovineSNP50 BeadChip was used identify single nucleotide polymorphisms (SNPs) that are associated with A least absolute shrinkage and selection operator (LASSO) applied detect multiple SNPs simultaneously 29 1,314 Chinese...
crown rot (FCR) in wheat is a prevalent soil-borne disease worldwide and poses significant threat to the production of (
Islet transplantation represents a potential cure for type 1 diabetes, yet persistent autoimmune and allogeneic immunities currently limit its clinical efficacy. For alleviating the destruction of transplanted islets, newly diagnosed NOD mice were provided single intramuscular injection recombinant adeno-associated viral vector encoding murine IL-10 (rAAV-IL-10) 4 weeks before renal capsule delivery 650 syngeneic islets. A dose-dependent protection islet grafts was observed. Sixty percent (3...
There is little comparative long-term clinical data comparing Bankart repair alone to the addition of remplissage.Our purpose was compare results patients with significant humeral head lesions and who underwent either isolated arthroscopic or remplissage.This a retrospective cohort study 14 10 remplissage repairs all large engaging Hill-Sachs (HS) lesions. Average follow-up 40.72 months (26.3-51.1) in group 31.55 (24.1-39.9) group. Surgical failure defined as dislocation subluxation. Groups...
Although human heme oxygenase-1 (hHO-1) could provide a useful approach for cellular protection in the ischemic heart, constitutive overexpression of hHO-1 may lead to unwanted side effects. To avoid this, we designed hypoxia-regulated gene therapy system that can be switched on and off. This vigilant plasmid is composed myosin light chain-2v promoter switch based an oxygen-dependent degradation domain from hypoxia inducible factor-1-α. The vector sense ischemia system, specifically heart....
Objectives: The effect of a cardiac specific, hypoxia-regulated, human heme oxygenase-1 (hHO-1) vector to provide cardioprotection from ischemia-reperfusion injury was assessed. Background: When myocardial ischemia and reperfusion is asymptomatic, the damaging effects are cumulative patients miss timely treatment. A gene therapy approach that expresses therapeutic genes only when experienced desirable strategy. We have developed cardiac-specific, hypoxia-regulated “vigilant vector” system...
Objectives β-blockers are widely used and effective for treating hypertension, acute myocardial infarction (MI) heart failure, but they present side-effects mainly due to antagonism of β2-adrenergic receptor (AR). Currently available at best selective not specific β1 or β2-AR. Methods To specifically inhibit the expression β1-AR, we developed a small interfering RNA (siRNA) targeted β1-AR. Three different sequences siRNA were delivered into C6-2B cells with 90% efficiency. Results One three...
Background —β-Blockers are the first line of therapy for hypertension. However, they associated with side effects because central nervous system (CNS) and β 2 -adrenergic antagonism. To overcome these problems provide a long-term 1 -blockade, antisense oligonucleotides against rat receptor (β -AR) mRNA -AS-ODN) were designed tested ability to inhibit cardiac -ARs as well lower blood pressure in spontaneously hypertensive rats (SHRs). Methods Results —Radioligand binding assay showed that...
Pancreatic cancer is one of the most recalcitrant and lethal all cancers. We examined effects Anemarrhena asphodeloides (AA) timosaponin-AIII (TAIII), a steroidal saponin present in AA, on pancreatic cell proliferation aimed to elucidate their potential apoptotic mechanisms action. Viability assays cycle analysis revealed that both AA TAIII significantly inhibited progression compared treatment with gemcitabine, standard chemotherapeutic agent for advanced cancer. identified dose-dependent...
Sequence capture across large phylogenetic scales is not easy because hybridization only effective when the genetic distance between bait and target small. Here, we propose a simple but strategy to tackle this issue: pooling DNA from number of selected representative species different clades prepare PCR-generated baits minimize target. To demonstrate utility strategy, newly developed set universal nuclear markers (including 94 protein-coding genes) for Lepidoptera, superdiverse insect group....
Abstract —To examine the relevance of angiotensin II type 1 receptor (AT R) expression in determination myocardial function after ischemia/reperfusion, Sprague-Dawley rats were treated intravenously with antisense oligodeoxynucleotides (AS-ODNs) directed at AT R mRNA (100 μg/rat, n=9) or scrambled (Scr-ODNs, 100 n=6). Both AS-ODNs and Scr-ODNs given along 300 μg/rat liposome DOTAP/DOPE, a positive electron carrier (wt:wt=1:1). The hearts from AS-ODN– Scr-ODN–treated excised 24 hours later,...