A5101635834- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Physiological and biochemical adaptations
- Viral-associated cancers and disorders
- Marine Bivalve and Aquaculture Studies
- Fish Biology and Ecology Studies
- Environmental Toxicology and Ecotoxicology
- Identification and Quantification in Food
- Genetic diversity and population structure
- Lymphoma Diagnosis and Treatment
- Crustacean biology and ecology
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Aquatic life and conservation
- Marine and fisheries research
- HVDC Systems and Fault Protection
- Herpesvirus Infections and Treatments
- Cancer-related gene regulation
- T-cell and Retrovirus Studies
- Polyomavirus and related diseases
- Geochemistry and Elemental Analysis
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
Guangdong Ocean University
2016-2025
Chinese Academy of Fishery Sciences
2024-2025
Academe of Grassland And Animal Science
2025
Baogang Group (China)
2024
Fuzhou University
2021
Weifang People's Hospital
2021
Weifang University
2021
Johns Hopkins University
2005-2012
Johns Hopkins Medicine
2007-2012
Sun Yat-sen University
2009-2010
The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) protein is functionally pleiotropic. LANA contributes to KSHV-associated pathogenesis, in part, by increasing entry of cells into S phase through a process that driven interaction with the serine-threonine kinase glycogen synthase 3 (GSK-3) and stabilization beta-catenin. We now show affects activity another involved cell cycle regulation, c-Myc. Sequencing c-Myc coding sequences revealed...
The Kaposi's sarcoma-associated herpesvirus (KSHV) LANA protein functions in latently infected cells as an essential participant KSHV genome replication and a driver of dysregulated cell growth. To identify novel protein-cell interactions that could contribute to these activities, we performed proteomic screen which purified, adenovirus-expressed Flag-LANA was incubated with array displaying 4,192 nonredundant human proteins. Sixty-one interacting proteins were consistently detected....
The Pacific white shrimp (Litopenaeus vannamei) is affected by the accumulation of ammonia and nitrite, in an intensive culture model. However, mechanisms combined stress toxicity remain unclear. We analyzed histopathology, antioxidant defense, immune competence, hepatopancreatic transcriptional responses under nitrite stress. results indicated that caused more extensive histopathological damage compared to single stresses. Deeper was observed hepatopancreas gills than muscles. Combined...
Ammonia nitrogen is one of the main toxic substances in aquatic cultivation environments. Chronic exposure to excessive amounts ammonia-N creates consequences, retarding growth organisms. This study investigated performance, morphological and physiological alterations, transcriptome changes hepatopancreas gills white shrimp Litopenaeus vannamei. The results showed that there was no significant difference survival rate (p > 0.05), whereas performance reduced significantly treated groups...
Yunnan Province, located in Southwestern China, the intricate geography, variable climate, and abundant vegetation of region have collectively contributed to shaping distinctive germplasm characteristics observed indigenous cattle through prolonged domestication. The different breeds exhibit distinct advantageous traits, which are an important source genetic variation because they might carry alleles that enable them adapt local environment tough feeding conditions. However, a comprehensive...
ABSTRACT The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) protein stabilizes β-catenin by the novel mechanism of binding to negative regulator, glycogen synthase kinase 3 (GSK-3), and depleting cytoplasmic GSK-3 levels. two domains LANA required for interaction with were further characterized. Evidence similarity between C-terminal domain axin was obtained using mutants. GSK-3(F291L), which does not interact axin, also failed bind LANA, a...
ABSTRACT The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen (LANA) protein interacts with glycogen synthase kinase 3 (GSK-3) and relocalizes GSK-3 in a manner that leads to stabilization of β-catenin upregulation β-catenin-responsive cell genes. LANA-GSK-3 interaction was further examined determine whether there were additional downstream consequences. In the present study, bound LANA transfected cells BCBL1 primary effusion lymphoma found be enriched for inactive...
Abstract Background Rheumatoid arthritis (RA) is an autoimmune rheumatic disease that carries a substantial burden for both patients and society. Early diagnosis of RA essential to prevent progression select optimal therapeutic strategy. However, challenging, partly due lack reliable biomarkers. Here, we aimed explore the diagnostic signature establish predictive model RA. Methods The mRNA expression profiling data GSE17755, containing blood samples 112 53 healthy control patients, were...
N6-methyladenosine (m6A) is the most abundant type of RNA modification in eukaryotes, yet information on m6A methylation enzymatic machinery decapod crustaceans quite scarce. Here, three essential genes for modification, including two methyltransferases (LvMETTL3 and LvWTAP) a m6A-binding protein (LvYTHDF2), were identified from Pacific whiteleg shrimp Litopenaeus vannamei. Their genomic structures dissected an evolutionary context. Common transcription factor binding sites conserved...
Increased concentrations of ammonia-N can cause seriously physiological harm to crustaceans, especially farmed shrimp (Litopenaeus vannamei). Ammonia-N is generally removed by water change, and will gradually accumulate for unconsumed feed. However, the underlying adaptation mechanism under such environmental conditions still not fully understood. A novel Sox gene expressed differentially in previous comparative transcriptome studies was characterized this study, designated as LvSoxB2–1. The...
Argopecten irradians concentricus has been cultivated along the southern coast of China for about 16 generations since its first introduction in 1991. To determine effects self-fertilization on production traits this isolated bay scallop population, 12 self-fertilized families and a mass-spawned group were produced studied. The hatching success survival at larvae, juvenile, adult stages offspring mass-mated all significantly greater than that 10 examined, not different from other 2 families....